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The map label for this gene is pyrH

Identifier: 15673992

GI number: 15673992

Start: 2087192

End: 2087908

Strand: Reverse

Name: pyrH

Synonym: L70624

Alternate gene names: 15673992

Gene position: 2087908-2087192 (Counterclockwise)

Preceding gene: 15673993

Following gene: 15673991

Centisome position: 88.26

GC content: 41.28

Gene sequence:

>717_bases
ATGGCTGAAATTAAATATAAACGCGTACTGTTAAAACTTTCGGGAGAGGCCCTCTCAGGCGAAAAAGGTTTCGGATTTGA
CCCTGAAACAGCAAAAGCTGTCGCTGAAGAACTCAAAGAAGTCCATGATTTGGGCGCAGAACTTGCGATTGTTTGCGGTG
GTGGTAATGTTTGGCGTGGAGTTACTGGTGAGAAAGCCGGAATGGAACGTGCTCAGGCAGATTACATGGGAATGCTTGCA
ACAATTCAAAATGGATTGTTCATTCAAAGTGCTCTTGAAAATATTGGGGTTGACACACGAGTGATGACAGCCATTGAGAT
GAAAGCTGTTGCTGAACCTTATATTCGTCGTCGTGCTGAACGCCATTTAGAAAAGGGACGTGTTGTCATTTTTGCTGGGG
GAACTGGTTCGCCTTACTTCTCAACTGATACAACTTCTGCATTACGTGCTGCGGAAATTAATGCTGATGTCATTTTAATG
GCTAAAAATGGTGTTGATGGTGTTTATAATGCTGACCCTAAATTAGTTGCTGATGCTATTAAATTTGAACATTTGACACA
TATGGATGTTATTACCAAAGGCTTGCAAGTAATGGACAGTACGGCTTCAACAATGTCAATGGATAATCATATTCCACTTG
TTGTTTTCAACATGAATGAAGCTGGAAATATTACACGTGTCGTTCGTGGTGAAGAAATCGGAACAACGGTTGAATAA

Upstream 100 bases:

>100_bases
TTTATTGACATCATGATAGTTTCTAAAAAGGCTTTGATTAGTCTTTTTTTCGTGAGCATTTTATGGTAAAATAGAGAAAA
TATAATAGAATAGGTGCAAT

Downstream 100 bases:

>100_bases
GATTTACTTACAAAAAAGTTGTCAGTAAATTTATTCATTAAAAAATTACTGATGGAAATACTAGCATATTCGTAAACGCT
GAAGCGTCAACGACTATCCT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MAEIKYKRVLLKLSGEALSGEKGFGFDPETAKAVAEELKEVHDLGAELAIVCGGGNVWRGVTGEKAGMERAQADYMGMLA
TIQNGLFIQSALENIGVDTRVMTAIEMKAVAEPYIRRRAERHLEKGRVVIFAGGTGSPYFSTDTTSALRAAEINADVILM
AKNGVDGVYNADPKLVADAIKFEHLTHMDVITKGLQVMDSTASTMSMDNHIPLVVFNMNEAGNITRVVRGEEIGTTVE

Sequences:

>Translated_238_residues
MAEIKYKRVLLKLSGEALSGEKGFGFDPETAKAVAEELKEVHDLGAELAIVCGGGNVWRGVTGEKAGMERAQADYMGMLA
TIQNGLFIQSALENIGVDTRVMTAIEMKAVAEPYIRRRAERHLEKGRVVIFAGGTGSPYFSTDTTSALRAAEINADVILM
AKNGVDGVYNADPKLVADAIKFEHLTHMDVITKGLQVMDSTASTMSMDNHIPLVVFNMNEAGNITRVVRGEEIGTTVE
>Mature_237_residues
AEIKYKRVLLKLSGEALSGEKGFGFDPETAKAVAEELKEVHDLGAELAIVCGGGNVWRGVTGEKAGMERAQADYMGMLAT
IQNGLFIQSALENIGVDTRVMTAIEMKAVAEPYIRRRAERHLEKGRVVIFAGGTGSPYFSTDTTSALRAAEINADVILMA
KNGVDGVYNADPKLVADAIKFEHLTHMDVITKGLQVMDSTASTMSMDNHIPLVVFNMNEAGNITRVVRGEEIGTTVE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=47.4137931034483, Blast_Score=212, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_LACLA (Q9CE38)

Other databases:

- EMBL:   AE005176
- PIR:   B86876
- RefSeq:   NP_268167.1
- ProteinModelPortal:   Q9CE38
- SMR:   Q9CE38
- GeneID:   1115686
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L70624
- NMPDR:   fig|272623.1.peg.2064
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   LLAC272623:L70624-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25678; Mature: 25547

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKYKRVLLKLSGEALSGEKGFGFDPETAKAVAEELKEVHDLGAELAIVCGGGNVWRG
CCCCHHEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEECC
VTGEKAGMERAQADYMGMLATIQNGLFIQSALENIGVDTRVMTAIEMKAVAEPYIRRRAE
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFAGGTGSPYFSTDTTSALRAAEINADVILMAKNGVDGVYNADPKLVADAI
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHEECCCCEEEEEECCCCCCCCCCHHHHHHHH
KFEHLTHMDVITKGLQVMDSTASTMSMDNHIPLVVFNMNEAGNITRVVRGEEIGTTVE
HHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
AEIKYKRVLLKLSGEALSGEKGFGFDPETAKAVAEELKEVHDLGAELAIVCGGGNVWRG
CCCHHEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEECC
VTGEKAGMERAQADYMGMLATIQNGLFIQSALENIGVDTRVMTAIEMKAVAEPYIRRRAE
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
RHLEKGRVVIFAGGTGSPYFSTDTTSALRAAEINADVILMAKNGVDGVYNADPKLVADAI
HHHHCCCEEEEECCCCCCCCCCCCHHHHHHEECCCCEEEEEECCCCCCCCCCHHHHHHHH
KFEHLTHMDVITKGLQVMDSTASTMSMDNHIPLVVFNMNEAGNITRVVRGEEIGTTVE
HHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471