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Identifier: 15673896

GI number: 15673896

Start: 1992107

End: 1992742

Strand: Reverse

Name: upp

Synonym: L175538

Alternate gene names: 15673896

Gene position: 1992742-1992107 (Counterclockwise)

Preceding gene: 15673897

Following gene: 15673895

Centisome position: 84.24

GC content: 38.84

Gene sequence:

>636_bases
ATGTCAAAATTTCAAGTCGTAGAACATCCATTGATTCAACACAAACTCTCAATCTTGCGTCGTAAAGAGGCATCGACAAA
AGAATTCCGTGAACTTGTTGATGAAATTGGAATGCTCATGGCCTACGAAGTATCAAGAGATTTACCCCTTGAAGATGTCG
AAATCGAAACACCCGTTCAAAAAACGACAGTTAAACAAATCGCAGGTAAAAAATTAGCGATTGTACCAATCTTGCGTGCT
GGTATTGGGATGGTAGACGGAATTTTGAAATTGATTCCAGCTGCTCGTGTAGGGCATATCGGAATGTATCGTGACGAAGA
AACACTTAAACCAGTTGAATATTTAGTTAAACTTCCAGCCGACATTGCTGACCGTCAAATTTTCCTTGTTGACCCAATGC
TTGCGACTGGTGGTTCAGCAATTTTAGCAGTTGATTCTCTTAAAAAACGAAATGCTAAAGCAGAAAATATTAAATTTGTT
TGTCTTGTTGCTGCACCAGAAGGAGTGAAAGCTCTCCAAAAAGCACATCCAGATATTGAAATTTATACTGCAGCTTTGGA
TGAAAAACTTAATGAACATGGTTATATTGTCCCAGGTCTTGGTGATGCTGGAGACCGTTTGTTCGGTACTAAATAA

Upstream 100 bases:

>100_bases
TCTAAAAAATTTTGCCTAAAATTAGCAAAATTGCCTTTTAAAGGCAGTTTATAAATCTGAACTTTGCTTAGCAAAGAGAT
CTAGCGAAAGGAAAATCAAA

Downstream 100 bases:

>100_bases
TAAATTTATCCCTATTTCAAATAGGGATTTTTTTTATTTTATAAAAAAAGTAATTTTTTGAATCAAAATAGTTTACAAGT
GTAAATTTATTTGATAAGAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRA
GIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFV
CLVAAPEGVKALQKAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_211_residues
MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRA
GIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFV
CLVAAPEGVKALQKAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
>Mature_210_residues
SKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQKTTVKQIAGKKLAIVPILRAG
IGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPADIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVC
LVAAPEGVKALQKAHPDIEIYTAALDEKLNEHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=32.6732673267327, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=32.6732673267327, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI21450816, Length=194, Percent_Identity=28.8659793814433, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=57.0731707317073, Blast_Score=248, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17539892, Length=207, Percent_Identity=27.536231884058, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17539894, Length=207, Percent_Identity=27.536231884058, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=40.625, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28573516, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573514, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI28573512, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550449, Length=205, Percent_Identity=32.1951219512195, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21358379, Length=197, Percent_Identity=26.3959390862944, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_LACLA (Q9CEC9)

Other databases:

- EMBL:   AE005176
- PIR:   B86864
- RefSeq:   NP_268071.1
- ProteinModelPortal:   Q9CEC9
- SMR:   Q9CEC9
- GeneID:   1115582
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L175538
- NMPDR:   fig|272623.1.peg.1961
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- BioCyc:   LLAC272623:L175538-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23231; Mature: 23099

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 196-196 BINDING 202-202

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQ
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHH
KTTVKQIAGKKLAIVPILRAGIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPA
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHCCC
DIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVCLVAAPEGVKALQKAHPDIE
CCCCCEEEEECCHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCCE
IYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
EEHHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SKFQVVEHPLIQHKLSILRRKEASTKEFRELVDEIGMLMAYEVSRDLPLEDVEIETPVQ
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHH
KTTVKQIAGKKLAIVPILRAGIGMVDGILKLIPAARVGHIGMYRDEETLKPVEYLVKLPA
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHCCC
DIADRQIFLVDPMLATGGSAILAVDSLKKRNAKAENIKFVCLVAAPEGVKALQKAHPDIE
CCCCCEEEEECCHHHCCCCEEEEEHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCCE
IYTAALDEKLNEHGYIVPGLGDAGDRLFGTK
EEHHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471