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The map label for this gene is thrS

Identifier: 15673893

GI number: 15673893

Start: 1987130

End: 1989070

Strand: Reverse

Name: thrS

Synonym: L0357

Alternate gene names: 15673893

Gene position: 1989070-1987130 (Counterclockwise)

Preceding gene: 15673894

Following gene: 15673892

Centisome position: 84.08

GC content: 39.41

Gene sequence:

>1941_bases
ATGATTAAAATAACATTTCCAGACGGTAACGTAAAAGAATTTGAGGCGGGCGTAACAACATTTGAAATTGCTAAATCAAT
CTCACCTAGTCTTGCCAAAAAAACACTTGCAGGTAAGGTCAACGGAAAATTGATTGATGCCACTCGAGCAATCAATGAAG
ATAGCAACTTTGAAATTGTAACACCAGACCATGAAGATGCACTTGGAATTTTACGACATTCAGCTGCTCACCTTTTTGCT
CAAGCAGCAAAACGCCATTTCCCTGATATTCACTTGGGTGTTGGACCAGCTATTCAAGATGGTTTCTATTACGATACAGA
TAACGAAGCCGGTCAAATTTCAAATGATGATTTGGCAACAATTGAAGCTGAAATGAAGAAAATTGTTAAAGAAAACTTCA
AATCAGAACGTAAAGAAGTAAGCAAAGAAGAAGCAAAAGAAATTTTTGCAAATGATCCATACAAACTCGAACTCATTGAA
GAACACAATGAAGATGAAGGTGGACTTACTATCTATACTCAAGGTGAATATACTGACCTTTGCCGCGGCCCACACGTTCC
ATCAACTGGTGTCATCAAATTTTTCCACCTTCTCAACGTTGCAGGTGCTTACTGGCGCGGTAATTCTGATAACAAGATGA
TGCAACGTATTTACGGTACAGCTTGGTTTACAAAAGAAGAATTAGAAGAAAATCTTAAACTTCGTGAAGAAGCAAAAGAA
CGTGACCACCGTAAACTCGGTCGCGAACTTGACTTGTTCTTTAATGACGCAGAACTTGGTGCGGGAACTGCTTACTGGCT
CCCAGCTGGAGCAACAATTCGTCGAATTATTGAACGTTTTGTCGTTGACCAAGAGGTGAAAAACGGTTATCAACACGTTA
TCACACCAGTCATGATGAACCTTAATACTTATAAACAATCAGGTCACTGGCAACATTACCATGAAGATATGTATCCACCA
ATGGATATGGGTGATGGCGAAGAAATGGAACTTCGTCCAATGAACTGTCCGAGCCATATTGCTATCTATAAACATCACGT
TCACTCTTATCGTGAACTCCCAATTCGTATTGCTGAATTTGGGATGATGCACCGTTATGAAAAATCAGGAGCACTTTCAG
GACTTCAACGTGTCCGCGAAATGACTTTGAATGATGGTCATACTTTCGTCATGTTAGAACAAGTTCAAGAAGAATTTAGT
AAAATTCTTCAATTGATTATGGACATGTACCGTGACTTTGGAATCAATGATTACAGCTTCCGACTCAGCTACCGTGACCC
TAAAGATACAGTGAAGTATTTCCCAGATGATGAAATGTGGGAAAAATCTCAAGCCATGCTCAAAGCGACAATGGATGACA
TGAATCTTGACTACGTTGAAGCAGAAGGAGAAGCAGCATTTTACGGTCCTAAACTTGACATTCAAGTTAAAACTGCGCTT
GGTAATGAAGAAACACTTTCAACTATTCAGTTGGACTTCCTTAATCCTGAAAACTTTGACATTTCGTATATCGGTGCTGA
CGGGGAAAAACATCGCCCAGTAATGATTCACCGTGGCGTAATCTCAACACTTGAACGTTTCATTGCCTACCTTATCGAAG
TTTATAAAGGTGCTTTCCCAACATGGCTCGCTCCAACTCAAGCAACCATTATCCCAGTAAATAATGAAATTCATGCCGAT
TACGCATGGAAAATTCAACGTGAACTTCAAGATAAAGGATTCCGCGTTGTTGTCGATGAAGCCAATGAAAAAATGGGCTG
GAAGATTCGTCAATCACAAACACACAAAATTCCATATCAAATCGTTATTGGAGACCAAGAACAAGCTGATGGAACTGTAA
ATATTCGTCGTTATGGCTCAAAAGAAACAAAAGTCATTCCGCTTGAAGAATTTATTGAAAATATCAGCGCAGATGTTGCT
AATTTTAGCCGCGTTGATTAA

Upstream 100 bases:

>100_bases
TTTTTATTTCCATAAATTATTGACAAGACTTTTAACAAGTAATTCGGATTTTTCTGTCAGTAATTTCCAACTAAAAAAAG
ATTAAAGAAAGGCACATAAA

Downstream 100 bases:

>100_bases
AGAAAAAGAGACTGTTGAAAATCAGTCTCTTTTTTATTTATATTGGAGAATTATAGGGTATAATAAATTGTATTAAAAAG
ATTATTAAGGTGAAGTATAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MIKITFPDGNVKEFEAGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIVTPDHEDALGILRHSAAHLFA
QAAKRHFPDIHLGVGPAIQDGFYYDTDNEAGQISNDDLATIEAEMKKIVKENFKSERKEVSKEEAKEIFANDPYKLELIE
EHNEDEGGLTIYTQGEYTDLCRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFTKEELEENLKLREEAKE
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMNLNTYKQSGHWQHYHEDMYPP
MDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEFGMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFS
KILQLIMDMYRDFGINDYSFRLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMNLDYVEAEGEAAFYGPKLDIQVKTAL
GNEETLSTIQLDFLNPENFDISYIGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFPTWLAPTQATIIPVNNEIHAD
YAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQIVIGDQEQADGTVNIRRYGSKETKVIPLEEFIENISADVA
NFSRVD

Sequences:

>Translated_646_residues
MIKITFPDGNVKEFEAGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIVTPDHEDALGILRHSAAHLFA
QAAKRHFPDIHLGVGPAIQDGFYYDTDNEAGQISNDDLATIEAEMKKIVKENFKSERKEVSKEEAKEIFANDPYKLELIE
EHNEDEGGLTIYTQGEYTDLCRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFTKEELEENLKLREEAKE
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMNLNTYKQSGHWQHYHEDMYPP
MDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEFGMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFS
KILQLIMDMYRDFGINDYSFRLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMNLDYVEAEGEAAFYGPKLDIQVKTAL
GNEETLSTIQLDFLNPENFDISYIGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFPTWLAPTQATIIPVNNEIHAD
YAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQIVIGDQEQADGTVNIRRYGSKETKVIPLEEFIENISADVA
NFSRVD
>Mature_646_residues
MIKITFPDGNVKEFEAGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIVTPDHEDALGILRHSAAHLFA
QAAKRHFPDIHLGVGPAIQDGFYYDTDNEAGQISNDDLATIEAEMKKIVKENFKSERKEVSKEEAKEIFANDPYKLELIE
EHNEDEGGLTIYTQGEYTDLCRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFTKEELEENLKLREEAKE
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMNLNTYKQSGHWQHYHEDMYPP
MDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEFGMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFS
KILQLIMDMYRDFGINDYSFRLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMNLDYVEAEGEAAFYGPKLDIQVKTAL
GNEETLSTIQLDFLNPENFDISYIGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFPTWLAPTQATIIPVNNEIHAD
YAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQIVIGDQEQADGTVNIRRYGSKETKVIPLEEFIENISADVA
NFSRVD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=637, Percent_Identity=37.9905808477237, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI38570111, Length=624, Percent_Identity=37.8205128205128, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI20070344, Length=652, Percent_Identity=32.8220858895706, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1788013, Length=647, Percent_Identity=39.5672333848532, Blast_Score=503, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI71984184, Length=618, Percent_Identity=39.6440129449838, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71984192, Length=618, Percent_Identity=39.9676375404531, Blast_Score=449, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322112, Length=634, Percent_Identity=35.9621451104101, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322654, Length=401, Percent_Identity=35.1620947630923, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24583839, Length=636, Percent_Identity=37.7358490566038, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24583842, Length=636, Percent_Identity=37.7358490566038, Blast_Score=447, Evalue=1e-125,
Organism=Drosophila melanogaster, GI28574141, Length=636, Percent_Identity=37.7358490566038, Blast_Score=447, Evalue=1e-125,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_LACLA (Q9CED2)

Other databases:

- EMBL:   AE005176
- PIR:   G86863
- RefSeq:   NP_268068.1
- ProteinModelPortal:   Q9CED2
- SMR:   Q9CED2
- GeneID:   1115578
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0357
- NMPDR:   fig|272623.1.peg.1958
- HOGENOM:   HBG352811
- OMA:   NDETMST
- ProtClustDB:   PRK00413
- BioCyc:   LLAC272623:L0357-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74197; Mature: 74197

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKITFPDGNVKEFEAGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIV
CEEEECCCCCHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCEEEEHHHHCCCCCCEEEE
TPDHEDALGILRHSAAHLFAQAAKRHFPDIHLGVGPAIQDGFYYDTDNEAGQISNDDLAT
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCHHH
IEAEMKKIVKENFKSERKEVSKEEAKEIFANDPYKLELIEEHNEDEGGLTIYTQGEYTDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCHHH
CRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFTKEELEENLKLREEAKE
HCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMN
HHHHHHCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LNTYKQSGHWQHYHEDMYPPMDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEF
CHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHH
GMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFSKILQLIMDMYRDFGINDYSF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
RLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMNLDYVEAEGEAAFYGPKLDIQVKTAL
EEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCEEEEEEEECC
GNEETLSTIQLDFLNPENFDISYIGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFP
CCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
TWLAPTQATIIPVNNEIHADYAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQ
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCEE
IVIGDQEQADGTVNIRRYGSKETKVIPLEEFIENISADVANFSRVD
EEECCCCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKITFPDGNVKEFEAGVTTFEIAKSISPSLAKKTLAGKVNGKLIDATRAINEDSNFEIV
CEEEECCCCCHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCEEEEHHHHCCCCCCEEEE
TPDHEDALGILRHSAAHLFAQAAKRHFPDIHLGVGPAIQDGFYYDTDNEAGQISNDDLAT
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCHHH
IEAEMKKIVKENFKSERKEVSKEEAKEIFANDPYKLELIEEHNEDEGGLTIYTQGEYTDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCCHHH
CRGPHVPSTGVIKFFHLLNVAGAYWRGNSDNKMMQRIYGTAWFTKEELEENLKLREEAKE
HCCCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGRELDLFFNDAELGAGTAYWLPAGATIRRIIERFVVDQEVKNGYQHVITPVMMN
HHHHHHCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
LNTYKQSGHWQHYHEDMYPPMDMGDGEEMELRPMNCPSHIAIYKHHVHSYRELPIRIAEF
CHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHH
GMMHRYEKSGALSGLQRVREMTLNDGHTFVMLEQVQEEFSKILQLIMDMYRDFGINDYSF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
RLSYRDPKDTVKYFPDDEMWEKSQAMLKATMDDMNLDYVEAEGEAAFYGPKLDIQVKTAL
EEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCEEEEEEEECC
GNEETLSTIQLDFLNPENFDISYIGADGEKHRPVMIHRGVISTLERFIAYLIEVYKGAFP
CCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCC
TWLAPTQATIIPVNNEIHADYAWKIQRELQDKGFRVVVDEANEKMGWKIRQSQTHKIPYQ
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCCCCEE
IVIGDQEQADGTVNIRRYGSKETKVIPLEEFIENISADVANFSRVD
EEECCCCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471