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The map label for this gene is proC

Identifier: 15673866

GI number: 15673866

Start: 1952692

End: 1953480

Strand: Direct

Name: proC

Synonym: L135991

Alternate gene names: 15673866

Gene position: 1952692-1953480 (Clockwise)

Preceding gene: 15673844

Following gene: 15673885

Centisome position: 82.55

GC content: 35.74

Gene sequence:

>789_bases
ATGAAAACAATAGGTTTTATTGGAGTTGGAAAAATGGCAACAGCTATTATTTCTGGACTTGACAAAAATAAATTCAAAAT
CATCATTTCCGGACACAATTTAACAAAAACTCAAAAACAAGCGGAAACCCTTAATGTTACGGCTACAAGTAATCATGAAG
AACTCGTTCAAGAATCTGATTTTATCATTCTATCAGTTAAACCTCAAGTACTTCCCTCTGTTTTAAGTAAATTAATCAAT
CATTTAACTAAAGACAAAACATTAATTTCAATTGCAGCGGGACTCACTTTATCTGACTTGAAACATCTGGCTGATTCAGA
AAATCAACCAATCATCCGAGTGATGCCAAATATCAATGCACAAATCGGTCAGTCAACATCGGCCATTGTCAAAAATGAAT
TTGTTGATGATTCTGCTTATGCTACAGTTCAAGAAATTTTTAAATCAACTGGTTCTGTCCATGAAATTGCTGAAAAAGAT
TTTTCAACATTTGCAGCAATTGCCGGTTCAAGCCCTGCTTTTATTTATATGTTCATTGATGCCATGGCACGTGCCGGTGT
ATTGCATGGTATTCCTAAAGATCAAGCCACAGCAATTGTTGCCGAAACGGTTCGTGCTTCAGCTGAAATGATTCTCCAAA
GTGGTGAAAATCCTTGGTCATTAGTCGATAAAGTCTCAAGTCCTGGTGGAACTACTGTCGCTGGTGTGGTAAGTTTAGAA
CAAAACCATTTTATCGGAACAGTTATTGATGCTATTAGCGCTACTATCGAAAAAGAAAAAAATCTTTAA

Upstream 100 bases:

>100_bases
AGACTTAGAAAAAATCTGATTTATTTTACGATGCTACTAAAGTGATTTATTATTACTTTTTATGATAAAATGGACGAAAA
GAAAAGAAGGGATTTTATTT

Downstream 100 bases:

>100_bases
AAATAAAAAAACTAGAAGGAAAACGATCCTTTTAGTTTTTAATTTATAAAATAAACGCAAATTGCAAGTCCAAGTTAGCC
AGCCAAGCTCATCTCATATG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKTIGFIGVGKMATAIISGLDKNKFKIIISGHNLTKTQKQAETLNVTATSNHEELVQESDFIILSVKPQVLPSVLSKLIN
HLTKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINAQIGQSTSAIVKNEFVDDSAYATVQEIFKSTGSVHEIAEKD
FSTFAAIAGSSPAFIYMFIDAMARAGVLHGIPKDQATAIVAETVRASAEMILQSGENPWSLVDKVSSPGGTTVAGVVSLE
QNHFIGTVIDAISATIEKEKNL

Sequences:

>Translated_262_residues
MKTIGFIGVGKMATAIISGLDKNKFKIIISGHNLTKTQKQAETLNVTATSNHEELVQESDFIILSVKPQVLPSVLSKLIN
HLTKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINAQIGQSTSAIVKNEFVDDSAYATVQEIFKSTGSVHEIAEKD
FSTFAAIAGSSPAFIYMFIDAMARAGVLHGIPKDQATAIVAETVRASAEMILQSGENPWSLVDKVSSPGGTTVAGVVSLE
QNHFIGTVIDAISATIEKEKNL
>Mature_262_residues
MKTIGFIGVGKMATAIISGLDKNKFKIIISGHNLTKTQKQAETLNVTATSNHEELVQESDFIILSVKPQVLPSVLSKLIN
HLTKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINAQIGQSTSAIVKNEFVDDSAYATVQEIFKSTGSVHEIAEKD
FSTFAAIAGSSPAFIYMFIDAMARAGVLHGIPKDQATAIVAETVRASAEMILQSGENPWSLVDKVSSPGGTTVAGVVSLE
QNHFIGTVIDAISATIEKEKNL

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=29.9242424242424, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=30.1115241635688, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797097, Length=272, Percent_Identity=28.6764705882353, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI24797095, Length=272, Percent_Identity=28.6764705882353, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=37.7358490566038, Blast_Score=174, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=30.5660377358491, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=35.0180505415162, Blast_Score=123, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320861, Length=273, Percent_Identity=26.007326007326, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21358587, Length=255, Percent_Identity=34.9019607843137, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24648116, Length=271, Percent_Identity=30.6273062730627, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24647700, Length=159, Percent_Identity=32.0754716981132, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27972; Mature: 27972

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIGFIGVGKMATAIISGLDKNKFKIIISGHNLTKTQKQAETLNVTATSNHEELVQESD
CCCEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHEEEEEECCCHHHHHHCCC
FIILSVKPQVLPSVLSKLINHLTKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINA
EEEEEECHHHHHHHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
QIGQSTSAIVKNEFVDDSAYATVQEIFKSTGSVHEIAEKDFSTFAAIAGSSPAFIYMFID
CCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHH
AMARAGVLHGIPKDQATAIVAETVRASAEMILQSGENPWSLVDKVSSPGGTTVAGVVSLE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEC
QNHFIGTVIDAISATIEKEKNL
CCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTIGFIGVGKMATAIISGLDKNKFKIIISGHNLTKTQKQAETLNVTATSNHEELVQESD
CCCEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHEEEEEECCCHHHHHHCCC
FIILSVKPQVLPSVLSKLINHLTKDKTLISIAAGLTLSDLKHLADSENQPIIRVMPNINA
EEEEEECHHHHHHHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHCCCCCCEEEECCCCCC
QIGQSTSAIVKNEFVDDSAYATVQEIFKSTGSVHEIAEKDFSTFAAIAGSSPAFIYMFID
CCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHH
AMARAGVLHGIPKDQATAIVAETVRASAEMILQSGENPWSLVDKVSSPGGTTVAGVVSLE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEEEEC
QNHFIGTVIDAISATIEKEKNL
CCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]