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The map label for this gene is uxaC

Identifier: 15673610

GI number: 15673610

Start: 1673004

End: 1674422

Strand: Reverse

Name: uxaC

Synonym: L0019

Alternate gene names: 15673610

Gene position: 1674422-1673004 (Counterclockwise)

Preceding gene: 15673611

Following gene: 15673609

Centisome position: 70.78

GC content: 34.04

Gene sequence:

>1419_bases
ATGAAATTTTTATCAGAAGATTTTTTACTAACGAATGAAAGTGCCAAGATGCTTTTTCACAAACATGCAGAAAAAATGCC
AATTATTGATTATCATTGCCATCTTGAACCCGCAGAAATTTATGAAAATAAAAAATATGAAAATTTAACACAAATTTGGC
TAGGTGGGGATCATTATAAATGGCGTTTGCTCCGTGCGAATGGTATTCCTGAAAAATTGATTACTGGAGATGGAGAGGAT
TATGAAAAGTTTTTAGCATTTGCTAAAACACTCGAAAAATCATTTGGTAATCCAATTTATGAATGGACTCATCTGGAATT
AAAACGATTTTTCCATATTGATAAGTTGATTTCAAGCGAGACAGCCAAAGAAATTTGGGATGAAGCGAACCAAATGCTTG
CCACAGATGATTTCAGACCACGCGCATTGATTAAAAATTCACAGGTAAAAGTTGTTTGTACAACAGATGACCCTGTTTCA
ACGCTTTCTTATCATAAATTATTAGCCAAAGAGGAAAAAGATTTCAAAGTTTTGCCAGCTTTAAGACCAGACCATTTAAT
TTCGATTACTGACGGACATTTTGCAGACTATTTGACAGAGCTGTCAGCAGTTTCTGGAATTGAAATAAAAGGTTTTAAGA
CGATGATTAAGGCACTTGAACAAAGATTTGAATTTTTCACAAGCCTTGGTGGACGTTTGTCTGACCACTCCTTATCTACC
TATACTTTTGCAGAAACTAAAAACGTGGATTTAGATTCTATCCTTCAGAAAGCCAAAGAAAATCAAACTTTAACGGACCT
AGAATATAATCAATACATTACGGCATTAATCCTTGAAATTATGAAATTAAATAAAAAATTTGAATGGACAATGCAACTCC
ATGTTAACGTCAACCGTTCTATCAATGGCCCAGCCTTAAGTAAAATTGGTGAAAATACTGGATTTGATAGTATGGGTACT
CAAGCTAATATTTCTGAGGAATTAACCAAACTCTTTAGCAAAGCAGCAGAACTTGAAACCATACCAAAAACCATTCTATA
CTCCCTTAATCAAAATGATTGGCTTGAATTAGTCACAATGATTGGCTGTTTTCAAGGTGAAGGAGTGCAACAATTACAAC
TTGGAGCTGGTTGGTGGTTCAATGACACCAAAAAAGGAATGGAAAACCAATTAGAGATTTTTGCTTCACAAAGTTTATTG
TCCAATTTTGTAGGAATGTTGACAGATTCACGGAGCTTTTTAAGTTATCCACGTCATGAATATTTCCGTCGCGTCCTCTG
TAATTTTGTTGGACAGTTGATTGAAAATGGTAGAATCCCTGATAATGAAGCACTTGTTGGAAAAATGATTGAAGATATTA
GTTATAATAATGTGCATGATTATTTTGGATTTTTCAAAGATGAGGACTCTAATCAATGA

Upstream 100 bases:

>100_bases
AACAAGAACTCTTGCAAAAAGAAGGAAATATCAGCTTAAAATCAAATGAATCAAAAACTTATGAAGTTGAATTAACTTTT
AATAGTAATAAAGGAGAATC

Downstream 100 bases:

>100_bases
CTGAATTTATAACACTTGGCGAACCTTTAGTCGTTCTTGCCTCAGAAAATCAAGATATAAGTTTAGATGTAGCTGAGCAT
TTCAGCAAATATTTAGCTGG

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MKFLSEDFLLTNESAKMLFHKHAEKMPIIDYHCHLEPAEIYENKKYENLTQIWLGGDHYKWRLLRANGIPEKLITGDGED
YEKFLAFAKTLEKSFGNPIYEWTHLELKRFFHIDKLISSETAKEIWDEANQMLATDDFRPRALIKNSQVKVVCTTDDPVS
TLSYHKLLAKEEKDFKVLPALRPDHLISITDGHFADYLTELSAVSGIEIKGFKTMIKALEQRFEFFTSLGGRLSDHSLST
YTFAETKNVDLDSILQKAKENQTLTDLEYNQYITALILEIMKLNKKFEWTMQLHVNVNRSINGPALSKIGENTGFDSMGT
QANISEELTKLFSKAAELETIPKTILYSLNQNDWLELVTMIGCFQGEGVQQLQLGAGWWFNDTKKGMENQLEIFASQSLL
SNFVGMLTDSRSFLSYPRHEYFRRVLCNFVGQLIENGRIPDNEALVGKMIEDISYNNVHDYFGFFKDEDSNQ

Sequences:

>Translated_472_residues
MKFLSEDFLLTNESAKMLFHKHAEKMPIIDYHCHLEPAEIYENKKYENLTQIWLGGDHYKWRLLRANGIPEKLITGDGED
YEKFLAFAKTLEKSFGNPIYEWTHLELKRFFHIDKLISSETAKEIWDEANQMLATDDFRPRALIKNSQVKVVCTTDDPVS
TLSYHKLLAKEEKDFKVLPALRPDHLISITDGHFADYLTELSAVSGIEIKGFKTMIKALEQRFEFFTSLGGRLSDHSLST
YTFAETKNVDLDSILQKAKENQTLTDLEYNQYITALILEIMKLNKKFEWTMQLHVNVNRSINGPALSKIGENTGFDSMGT
QANISEELTKLFSKAAELETIPKTILYSLNQNDWLELVTMIGCFQGEGVQQLQLGAGWWFNDTKKGMENQLEIFASQSLL
SNFVGMLTDSRSFLSYPRHEYFRRVLCNFVGQLIENGRIPDNEALVGKMIEDISYNNVHDYFGFFKDEDSNQ
>Mature_472_residues
MKFLSEDFLLTNESAKMLFHKHAEKMPIIDYHCHLEPAEIYENKKYENLTQIWLGGDHYKWRLLRANGIPEKLITGDGED
YEKFLAFAKTLEKSFGNPIYEWTHLELKRFFHIDKLISSETAKEIWDEANQMLATDDFRPRALIKNSQVKVVCTTDDPVS
TLSYHKLLAKEEKDFKVLPALRPDHLISITDGHFADYLTELSAVSGIEIKGFKTMIKALEQRFEFFTSLGGRLSDHSLST
YTFAETKNVDLDSILQKAKENQTLTDLEYNQYITALILEIMKLNKKFEWTMQLHVNVNRSINGPALSKIGENTGFDSMGT
QANISEELTKLFSKAAELETIPKTILYSLNQNDWLELVTMIGCFQGEGVQQLQLGAGWWFNDTKKGMENQLEIFASQSLL
SNFVGMLTDSRSFLSYPRHEYFRRVLCNFVGQLIENGRIPDNEALVGKMIEDISYNNVHDYFGFFKDEDSNQ

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=464, Percent_Identity=46.9827586206897, Blast_Score=442, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_LACLA (Q9CF53)

Other databases:

- EMBL:   AE005176
- PIR:   D86828
- RefSeq:   NP_267784.1
- ProteinModelPortal:   Q9CF53
- SMR:   Q9CF53
- GeneID:   1115288
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0019
- NMPDR:   fig|272623.1.peg.1670
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- ProtClustDB:   PRK02925
- BioCyc:   LLAC272623:L0019-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 54414; Mature: 54414

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLSEDFLLTNESAKMLFHKHAEKMPIIDYHCHLEPAEIYENKKYENLTQIWLGGDHYK
CCCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCHHHEEECCCCEE
WRLLRANGIPEKLITGDGEDYEKFLAFAKTLEKSFGNPIYEWTHLELKRFFHIDKLISSE
EEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
TAKEIWDEANQMLATDDFRPRALIKNSQVKVVCTTDDPVSTLSYHKLLAKEEKDFKVLPA
HHHHHHHHHHHEEECCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEECCC
LRPDHLISITDGHFADYLTELSAVSGIEIKGFKTMIKALEQRFEFFTSLGGRLSDHSLST
CCCCCEEEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
YTFAETKNVDLDSILQKAKENQTLTDLEYNQYITALILEIMKLNKKFEWTMQLHVNVNRS
EEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCC
INGPALSKIGENTGFDSMGTQANISEELTKLFSKAAELETIPKTILYSLNQNDWLELVTM
CCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IGCFQGEGVQQLQLGAGWWFNDTKKGMENQLEIFASQSLLSNFVGMLTDSRSFLSYPRHE
HHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHH
YFRRVLCNFVGQLIENGRIPDNEALVGKMIEDISYNNVHDYFGFFKDEDSNQ
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKFLSEDFLLTNESAKMLFHKHAEKMPIIDYHCHLEPAEIYENKKYENLTQIWLGGDHYK
CCCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCCCCHHHEEECCCCEE
WRLLRANGIPEKLITGDGEDYEKFLAFAKTLEKSFGNPIYEWTHLELKRFFHIDKLISSE
EEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
TAKEIWDEANQMLATDDFRPRALIKNSQVKVVCTTDDPVSTLSYHKLLAKEEKDFKVLPA
HHHHHHHHHHHEEECCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEECCC
LRPDHLISITDGHFADYLTELSAVSGIEIKGFKTMIKALEQRFEFFTSLGGRLSDHSLST
CCCCCEEEECCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
YTFAETKNVDLDSILQKAKENQTLTDLEYNQYITALILEIMKLNKKFEWTMQLHVNVNRS
EEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCC
INGPALSKIGENTGFDSMGTQANISEELTKLFSKAAELETIPKTILYSLNQNDWLELVTM
CCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IGCFQGEGVQQLQLGAGWWFNDTKKGMENQLEIFASQSLLSNFVGMLTDSRSFLSYPRHE
HHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHH
YFRRVLCNFVGQLIENGRIPDNEALVGKMIEDISYNNVHDYFGFFKDEDSNQ
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471