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The map label for this gene is ffh

Identifier: 15673598

GI number: 15673598

Start: 1657076

End: 1658632

Strand: Reverse

Name: ffh

Synonym: L0158

Alternate gene names: 15673598

Gene position: 1658632-1657076 (Counterclockwise)

Preceding gene: 15673599

Following gene: 15673595

Centisome position: 70.11

GC content: 38.86

Gene sequence:

>1557_bases
ATGGCATTTGAAAACTTAACTGAACGCTTACAAAACGTTTTTAAAAATCTACGTGGAAAGAAAAAAATTACTGAGACAGA
CGTCACAGAAATTACAAAAGAAATCCGAGTTGCTCTCCTTGAAGCCGACGTTGCTCTCCCAGTTGTCAAGAAGTTTATTA
AGGCAATCCGTGAACGAGCTGTCGGTGTTGAAGTATCAGAAGCATTAAACCCAGCTCAACAAGTAATTAAAATTGTTGAT
GAAGAATTAACAGCTATTTTGGGTGGTGGCGAAGCTGAATTACTTAAATCTCCTAAAATTCCAACAATTATCATGATGGT
TGGGTTGCAAGGGGCAGGTAAAACAACTTTTGCTGGTAAACTTGCCAAAAAACTCAAAGAAGAGCAAAATGCTCGCCCTT
TAATGATTGCAGCCGACGTTTATCGTCCAGCAGCGATTGACCAATTAAAAACCTTAGGTGAACAGCTTGAAATTCCTGTC
TATGATGAAGGAACTGCTGAAAAACCAGTTAATATTGTTCGTAATGGTCTTTTAAAAGCTCAAGAAGAACGTAAAGACTA
TGTTTTGATTGATACTGCAGGTCGTCTTGAAATTGACGACACTTTAATGAACGAATTGCAAGAGATTAAAGCACTTGCTG
AACCAACTGAAATTTTGCTTGTTGTTGATGCAATGACTGGTCAAGTTGCAGCACAAGTTGCCAAGACTTTTGATGAAAAA
TTGGACATTACAGGTGTGATTATCACTAAACTTGATGGTGATACACGTGGTGGTGCGGCATTATCAATCCGTGAAATTAC
AGGAAAACCAATTAAATTTACAGGGACTGGTGAAAAATTAACAGACCTTGAAGTTTTCTATCCTGATCGAATGAGTTCAC
GAATTCTTGGAATGGGTGATATGCTCACCTTAATTGAGAAGGCTCAAGCAAATTATGACGAAGAACAATCAGCAAAACTC
GCTGAAAAAATGGCTGAAAACCGTTTTGATTATGAGGACTTTGTTGAACAACTTGATCAAGTGACAAATATGGGACCAAT
GGAAGATATTATGAAAATGATTCCAGGAATGTCACAAATGCCTGGTTTAGATAAGGTTAAAGTTGATCCTAAGGATGTTG
CCAGAAAACGAGCAATGGTCTTGTCAATGACACCGGCAGAACGTCATTTAGAGGCTGAACTGTCACCAGCCCGTCGTCGT
CGGATTGCCGCAGGTTCTGGAAATTCATTTATTGAAGTAAATAAATTCATTAAGCAATTCAATCAGTCCAAAGAAATGAT
GCAAGGAATCATGAATGGTGATATGAATGCTATGATGCAAAAAATGATGGGTGGAGCCGGTGGACAAATGCCGAATATGC
CTGCAGGTTCTGGAATGCCCGATATGTCATCTTTGGGTGATTTACAAGGGATGATGGGCAATGGTTCAGCAAATGGGATG
CCCGATATGAGTTCTATGTTTGGTGGTGGTTTAAAAGGTAAAGCAACTGAGTTTGCTATGAAACAAGCCATGAAACGTGC
TCAAAAGAAAATGAAAAAAGGTAAGAAAAAACGCTAA

Upstream 100 bases:

>100_bases
AGTGAAAAAAGATATCGACTAGAACTTTTGATGTATTCAATTTTAGCTAAAGAAATGTTATAATGAAGTAATTGTAAAAA
ATAGAATTGGATTATAAAAT

Downstream 100 bases:

>100_bases
ATAAAAACAGGAGTTCTCCTGTTTTTTTATTTAACCGCTTTTTCTCTTTGAGTATATTCAGATTTAAGAATCCCCATAAA
GTAGCTATCATGATATCTAC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MAFENLTERLQNVFKNLRGKKKITETDVTEITKEIRVALLEADVALPVVKKFIKAIRERAVGVEVSEALNPAQQVIKIVD
EELTAILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGKLAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLEIPV
YDEGTAEKPVNIVRNGLLKAQEERKDYVLIDTAGRLEIDDTLMNELQEIKALAEPTEILLVVDAMTGQVAAQVAKTFDEK
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGDMLTLIEKAQANYDEEQSAKL
AEKMAENRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQMPGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRR
RIAAGSGNSFIEVNKFIKQFNQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPAGSGMPDMSSLGDLQGMMGNGSANGM
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR

Sequences:

>Translated_518_residues
MAFENLTERLQNVFKNLRGKKKITETDVTEITKEIRVALLEADVALPVVKKFIKAIRERAVGVEVSEALNPAQQVIKIVD
EELTAILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGKLAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLEIPV
YDEGTAEKPVNIVRNGLLKAQEERKDYVLIDTAGRLEIDDTLMNELQEIKALAEPTEILLVVDAMTGQVAAQVAKTFDEK
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGDMLTLIEKAQANYDEEQSAKL
AEKMAENRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQMPGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRR
RIAAGSGNSFIEVNKFIKQFNQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPAGSGMPDMSSLGDLQGMMGNGSANGM
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR
>Mature_517_residues
AFENLTERLQNVFKNLRGKKKITETDVTEITKEIRVALLEADVALPVVKKFIKAIRERAVGVEVSEALNPAQQVIKIVDE
ELTAILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGKLAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLEIPVY
DEGTAEKPVNIVRNGLLKAQEERKDYVLIDTAGRLEIDDTLMNELQEIKALAEPTEILLVVDAMTGQVAAQVAKTFDEKL
DITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGDMLTLIEKAQANYDEEQSAKLA
EKMAENRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQMPGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRRR
IAAGSGNSFIEVNKFIKQFNQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPAGSGMPDMSSLGDLQGMMGNGSANGMP
DMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=507, Percent_Identity=31.5581854043393, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI226371618, Length=444, Percent_Identity=32.4324324324324, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI89061728, Length=139, Percent_Identity=41.0071942446043, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI295424842, Length=303, Percent_Identity=26.0726072607261, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI23308697, Length=303, Percent_Identity=26.0726072607261, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=49.5238095238095, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=34.5864661654135, Blast_Score=145, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=493, Percent_Identity=29.2089249492901, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=30.2721088435374, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=484, Percent_Identity=33.2644628099174, Blast_Score=235, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=25.8785942492013, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17647949, Length=359, Percent_Identity=34.8189415041783, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 56846; Mature: 56715

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFENLTERLQNVFKNLRGKKKITETDVTEITKEIRVALLEADVALPVVKKFIKAIRERA
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVEVSEALNPAQQVIKIVDEELTAILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGK
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
LAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLEIPVYDEGTAEKPVNIVRNGLLKA
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
QEERKDYVLIDTAGRLEIDDTLMNELQEIKALAEPTEILLVVDAMTGQVAAQVAKTFDEK
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHH
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGD
CCCEEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCCEEEECCCHHHHHHCCCHH
MLTLIEKAQANYDEEQSAKLAEKMAENRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQM
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRRRIAAGSGNSFIEVNKFIKQF
CCCCCCCCCHHHHHHHHHHHEEECCHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
NQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPAGSGMPDMSSLGDLQGMMGNGSANGM
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AFENLTERLQNVFKNLRGKKKITETDVTEITKEIRVALLEADVALPVVKKFIKAIRERA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVEVSEALNPAQQVIKIVDEELTAILGGGEAELLKSPKIPTIIMMVGLQGAGKTTFAGK
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEECCCCCCCHHHHH
LAKKLKEEQNARPLMIAADVYRPAAIDQLKTLGEQLEIPVYDEGTAEKPVNIVRNGLLKA
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
QEERKDYVLIDTAGRLEIDDTLMNELQEIKALAEPTEILLVVDAMTGQVAAQVAKTFDEK
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHH
LDITGVIITKLDGDTRGGAALSIREITGKPIKFTGTGEKLTDLEVFYPDRMSSRILGMGD
CCCEEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCCCEEEECCCHHHHHHCCCHH
MLTLIEKAQANYDEEQSAKLAEKMAENRFDYEDFVEQLDQVTNMGPMEDIMKMIPGMSQM
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PGLDKVKVDPKDVARKRAMVLSMTPAERHLEAELSPARRRRIAAGSGNSFIEVNKFIKQF
CCCCCCCCCHHHHHHHHHHHEEECCHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
NQSKEMMQGIMNGDMNAMMQKMMGGAGGQMPNMPAGSGMPDMSSLGDLQGMMGNGSANGM
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
PDMSSMFGGGLKGKATEFAMKQAMKRAQKKMKKGKKKR
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]