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The map label for this gene is proA

Identifier: 15673590

GI number: 15673590

Start: 1650618

End: 1651859

Strand: Reverse

Name: proA

Synonym: L0116

Alternate gene names: 15673590

Gene position: 1651859-1650618 (Counterclockwise)

Preceding gene: 15673591

Following gene: 15673587

Centisome position: 69.83

GC content: 37.44

Gene sequence:

>1242_bases
ATGATTGAAGAACTTGGATTAAAGGTTAAAAAGGCGAGCAAAGAAGTAGCAAAGCTATCAACTGCCGACAAAAATGTTTT
TTTGCAAAATTTAGCTGACAGCCTTATCGAAAATACTGACAGAATTATTTCTGAGAATGAAAAAGATTTGGCTAACGCTC
TGGAACATGGAATTTCTGAGATTATGGATGACCGTTTGCGTCTAAATGCGCAAAGAATTTCTGATATGGCAACAGGGTTG
AGACAAGTTGCAGAACTTCCTGACCCAATTAGGCAAGTATTGCAAGGTTTCACTAATCTTGATGGACTTAAGATTTTGCA
AAAAAGAGTGCCACTTGGCACTGTTGGAATGATTTTTGAAAGTCGTCCAAATGTGACTATCGATGCTTTTTCTCTTTGTT
TTAAAACAGGAAATTCTGTTTTGTTACGCGGTGGGTCTGACGCGATTTATTCTAATATGGTTTTAGTTGAAATTATTAAG
GAAAATTTGCTGTCAGCAAAAATTACTGACGGAGCAGTTGAATTGTTATCTGACACAAGTCATGCTGAAGCAGAAAAAAT
GATGCAGGCAGATAAATTTTTAGATGTTTTGATTCCGCGAGGGTCAGCGCGATTGATTAACCGTGTCAAAGAAAAAGCAA
CGGTTCCTGTCATTGAAACTGGGGTGGGTAATTGTACAATTTTTGTTGATGAATCTGCTGATTTAGAAATGGCGACAAAA
ATTGTGATAAATGCCAAAACACAGCGTCCTAGTGTTTGCAATGCAGCAGAAAGTTTAGTGGTTCACGCAAAAATTGCTGA
CGAATTTTTACCAAAGTTGGAAAATGAAATCAATAAAGTTCATGAAATTGAATTTCGTGCTGACGAGCGTGCGCTGAAAG
TTCTGTCAGCTGGAATTCCTGCAACTGACGATGATTTTGGGACAGAATTTTTAGATTATATTCTGTCAGTAAAAACGGTT
GATAATTTGGATGAAGCAATTGAGCACATTAATACTTATTCAAGTCGTCATTCAGAAAGCATTGTCACTCATGATTATTT
CAATGCGCAAAAATTTCAAGATGAAATTGATGCGGCAGCCGTTTATGTCAATGCGTCTACAAGATTTACTGACGGTTTTG
TATTTGGCTTAGGTGCTGAAATTGGCATTTCAACTCAAAAACTTCATGCCAGAGGGCCAATGGGCTTAGAGGCTCTAACC
TCAACAAAATATCTGATTGATGGCACAGGACAAATTCGTTAA

Upstream 100 bases:

>100_bases
TGACCAATGGCGAACGGATTCGAGAGATTAAAGAAATTATCGAAGGACGTGAGATTGGGACTTATTTTCATCAAAAATCT
TGAGAAAGAAGGATAAAACG

Downstream 100 bases:

>100_bases
AAATATTAAAAGACTCGGCTTTTTATAAGCCGAGTCTTTTAATTCATCAGTAATTTTATAAATTGACAAGTTCTGTCAGT
AATTAAATTTCATATTGAAC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MIEELGLKVKKASKEVAKLSTADKNVFLQNLADSLIENTDRIISENEKDLANALEHGISEIMDDRLRLNAQRISDMATGL
RQVAELPDPIRQVLQGFTNLDGLKILQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIK
ENLLSAKITDGAVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLEMATK
IVINAKTQRPSVCNAAESLVVHAKIADEFLPKLENEINKVHEIEFRADERALKVLSAGIPATDDDFGTEFLDYILSVKTV
DNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALT
STKYLIDGTGQIR

Sequences:

>Translated_413_residues
MIEELGLKVKKASKEVAKLSTADKNVFLQNLADSLIENTDRIISENEKDLANALEHGISEIMDDRLRLNAQRISDMATGL
RQVAELPDPIRQVLQGFTNLDGLKILQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIK
ENLLSAKITDGAVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLEMATK
IVINAKTQRPSVCNAAESLVVHAKIADEFLPKLENEINKVHEIEFRADERALKVLSAGIPATDDDFGTEFLDYILSVKTV
DNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALT
STKYLIDGTGQIR
>Mature_413_residues
MIEELGLKVKKASKEVAKLSTADKNVFLQNLADSLIENTDRIISENEKDLANALEHGISEIMDDRLRLNAQRISDMATGL
RQVAELPDPIRQVLQGFTNLDGLKILQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIK
ENLLSAKITDGAVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLEMATK
IVINAKTQRPSVCNAAESLVVHAKIADEFLPKLENEINKVHEIEFRADERALKVLSAGIPATDDDFGTEFLDYILSVKTV
DNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALT
STKYLIDGTGQIR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=413, Percent_Identity=34.6246973365617, Blast_Score=251, Evalue=6e-67,
Organism=Homo sapiens, GI62912457, Length=413, Percent_Identity=34.6246973365617, Blast_Score=251, Evalue=7e-67,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=46.2829736211031, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17569969, Length=414, Percent_Identity=34.2995169082126, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569967, Length=414, Percent_Identity=34.2995169082126, Blast_Score=249, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=34.1801385681293, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=34.718826405868, Blast_Score=251, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_LACLA (Q9CF73)

Other databases:

- EMBL:   AE005176
- PIR:   H86825
- RefSeq:   NP_267764.1
- ProteinModelPortal:   Q9CF73
- SMR:   Q9CF73
- GeneID:   1115268
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0116
- NMPDR:   fig|272623.1.peg.1650
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   LLAC272623:L0116-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45381; Mature: 45381

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEELGLKVKKASKEVAKLSTADKNVFLQNLADSLIENTDRIISENEKDLANALEHGISE
CCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IMDDRLRLNAQRISDMATGLRQVAELPDPIRQVLQGFTNLDGLKILQKRVPLGTVGMIFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEEE
SRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIKENLLSAKITDGAVELLSDTS
CCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
HAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLEMATK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCHHHHEE
IVINAKTQRPSVCNAAESLVVHAKIADEFLPKLENEINKVHEIEFRADERALKVLSAGIP
EEEECCCCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCC
ATDDDFGTEFLDYILSVKTVDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCEE
VYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKYLIDGTGQIR
EEEECCCEECCCEEEECCCCCCCCHHHHHCCCCCCHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MIEELGLKVKKASKEVAKLSTADKNVFLQNLADSLIENTDRIISENEKDLANALEHGISE
CCHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IMDDRLRLNAQRISDMATGLRQVAELPDPIRQVLQGFTNLDGLKILQKRVPLGTVGMIFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEEE
SRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIKENLLSAKITDGAVELLSDTS
CCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
HAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLEMATK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCHHHHEE
IVINAKTQRPSVCNAAESLVVHAKIADEFLPKLENEINKVHEIEFRADERALKVLSAGIP
EEEECCCCCCCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCC
ATDDDFGTEFLDYILSVKTVDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHCCEE
VYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKYLIDGTGQIR
EEEECCCEECCCEEEECCCCCCCCHHHHHCCCCCCHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471