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The map label for this gene is coaA

Identifier: 15673426

GI number: 15673426

Start: 1466541

End: 1467461

Strand: Direct

Name: coaA

Synonym: L66222

Alternate gene names: 15673426

Gene position: 1466541-1467461 (Clockwise)

Preceding gene: 30024044

Following gene: 15673431

Centisome position: 61.99

GC content: 34.85

Gene sequence:

>921_bases
ATGAATGAATTCATTAATTTTGACGAAATTAGCCGAAAAACATGGCAAAATCTTTATAATACTTCGATTGCTCCCTTAAC
TCATGATGAGTTAGAGTCAATCCGCTCACTCAATGATGAAATCAGCTTACAAGATGTGGAGGACGTCTATTTACCACTGA
TTCATCTTCTTCGCTTATATAAAAAAAATTTAGAAGACATGAGTTACTCTAAAGGACTTTTCCTACAAAAAATTGTCAAA
ACTCCCCCACTCATCATTGGGATTTCCGGCTCAGTCGCCGTTGGAAAATCAACGACTGCAAGACTTCTCCAGCTTCTCCT
TTCACGTGCCTTTCCAAAATTAACCGTTGATTTAGTGACAACCGACGGATTTTTGTACACGACTAATGATTTAAAAAATA
TGGGGATTCTCGACCGCAAAGGTTTTCCCGAAAGCTATGATATGGAAAAATTAACAAGTTTTCTTTATCACGTCAAAAAT
GGTGAAAAATTTGAAGTTCCGATTTACTCACATGAAACTTACGATATTTTGCCTAACCAAAGTCAAATCATTGACAGCCC
TGATATTCTTATTGTAGAAGGAATTAATGTGCTTCAAAATCCACAAAATCAACTACTTTATATCAGTGATTTTTACGATT
TTTCAATTTATGTCGATGCTGACGAAAAACTCATTGAAAAATGGTACCTCGAACGTTTTGACAGCCTTTTAAAACTAGCT
AAATATGACCAGACAAACTTCTATCATCAATTTACAAAAATGCCAGAAGATAAAGTAATCAATCTAGCCCGTGAAATATG
GGCACGTGTCAATCGTGTCAATCTCAGAGAATATATTGAGCCCACAAGAAATCGGGCAGAAATTATTCTCCACAAAACAG
AAAATCACTATATTGACAAAATTTACCTGAAAAAATTCTAA

Upstream 100 bases:

>100_bases
GACAGAAGTGTAAAAATCTTGTCAGTAACTTATTTAATACGCTTACAGATTTATTAGTTTTTTTACCTTGATAAGCCAAA
AATATGATATAATATTTTTC

Downstream 100 bases:

>100_bases
AAAAATACTGACAAATCTGTCAGTATTTTTTGTCTTCAATTTTACTGACAGAACTGTCAGACAAGATTAGAAATAATCTG
CTGTATCATCATTTGGAAAA

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNEFINFDEISRKTWQNLYNTSIAPLTHDELESIRSLNDEISLQDVEDVYLPLIHLLRLYKKNLEDMSYSKGLFLQKIVK
TPPLIIGISGSVAVGKSTTARLLQLLLSRAFPKLTVDLVTTDGFLYTTNDLKNMGILDRKGFPESYDMEKLTSFLYHVKN
GEKFEVPIYSHETYDILPNQSQIIDSPDILIVEGINVLQNPQNQLLYISDFYDFSIYVDADEKLIEKWYLERFDSLLKLA
KYDQTNFYHQFTKMPEDKVINLAREIWARVNRVNLREYIEPTRNRAEIILHKTENHYIDKIYLKKF

Sequences:

>Translated_306_residues
MNEFINFDEISRKTWQNLYNTSIAPLTHDELESIRSLNDEISLQDVEDVYLPLIHLLRLYKKNLEDMSYSKGLFLQKIVK
TPPLIIGISGSVAVGKSTTARLLQLLLSRAFPKLTVDLVTTDGFLYTTNDLKNMGILDRKGFPESYDMEKLTSFLYHVKN
GEKFEVPIYSHETYDILPNQSQIIDSPDILIVEGINVLQNPQNQLLYISDFYDFSIYVDADEKLIEKWYLERFDSLLKLA
KYDQTNFYHQFTKMPEDKVINLAREIWARVNRVNLREYIEPTRNRAEIILHKTENHYIDKIYLKKF
>Mature_306_residues
MNEFINFDEISRKTWQNLYNTSIAPLTHDELESIRSLNDEISLQDVEDVYLPLIHLLRLYKKNLEDMSYSKGLFLQKIVK
TPPLIIGISGSVAVGKSTTARLLQLLLSRAFPKLTVDLVTTDGFLYTTNDLKNMGILDRKGFPESYDMEKLTSFLYHVKN
GEKFEVPIYSHETYDILPNQSQIIDSPDILIVEGINVLQNPQNQLLYISDFYDFSIYVDADEKLIEKWYLERFDSLLKLA
KYDQTNFYHQFTKMPEDKVINLAREIWARVNRVNLREYIEPTRNRAEIILHKTENHYIDKIYLKKF

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=312, Percent_Identity=41.025641025641, Blast_Score=241, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_LACLA (Q9CFM3)

Other databases:

- EMBL:   AE005176
- PIR:   D86805
- RefSeq:   NP_267600.1
- ProteinModelPortal:   Q9CFM3
- SMR:   Q9CFM3
- GeneID:   1115100
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L66222
- NMPDR:   fig|272623.1.peg.1485
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   LLAC272623:L66222-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 35993; Mature: 35993

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEFINFDEISRKTWQNLYNTSIAPLTHDELESIRSLNDEISLQDVEDVYLPLIHLLRLY
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KKNLEDMSYSKGLFLQKIVKTPPLIIGISGSVAVGKSTTARLLQLLLSRAFPKLTVDLVT
HHHHHHCCHHCCHHHHHHHCCCCEEEECCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEE
TDGFLYTTNDLKNMGILDRKGFPESYDMEKLTSFLYHVKNGEKFEVPIYSHETYDILPNQ
CCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCC
SQIIDSPDILIVEGINVLQNPQNQLLYISDFYDFSIYVDADEKLIEKWYLERFDSLLKLA
HHHCCCCCEEEEECCHHHHCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
KYDQTNFYHQFTKMPEDKVINLAREIWARVNRVNLREYIEPTRNRAEIILHKTENHYIDK
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCCCCCEEE
IYLKKF
EEEECC
>Mature Secondary Structure
MNEFINFDEISRKTWQNLYNTSIAPLTHDELESIRSLNDEISLQDVEDVYLPLIHLLRLY
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
KKNLEDMSYSKGLFLQKIVKTPPLIIGISGSVAVGKSTTARLLQLLLSRAFPKLTVDLVT
HHHHHHCCHHCCHHHHHHHCCCCEEEECCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEE
TDGFLYTTNDLKNMGILDRKGFPESYDMEKLTSFLYHVKNGEKFEVPIYSHETYDILPNQ
CCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCC
SQIIDSPDILIVEGINVLQNPQNQLLYISDFYDFSIYVDADEKLIEKWYLERFDSLLKLA
HHHCCCCCEEEEECCHHHHCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
KYDQTNFYHQFTKMPEDKVINLAREIWARVNRVNLREYIEPTRNRAEIILHKTENHYIDK
HCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEEECCCCCCEEE
IYLKKF
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471