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The map label for this gene is murB

Identifier: 15673144

GI number: 15673144

Start: 1174130

End: 1175029

Strand: Direct

Name: murB

Synonym: L173881

Alternate gene names: 15673144

Gene position: 1174130-1175029 (Clockwise)

Preceding gene: 15673143

Following gene: 15673145

Centisome position: 49.63

GC content: 38.22

Gene sequence:

>900_bases
ATGATAAAAGAAACTGACCTTGAAAATATCCCAGATTTGCTGGTTAAATTTAATGAACCATTATCAAAATATACTTATAC
AAAAGTAGGTGGACCAGCAGATATCTTAGCTTTTCCAGCTACAATTGAAGCACTGACAGAATTATTAGTCAAAGCAAAAT
CAACTGACACAGCAGTTACTGTGCTTGGAAATGCTTCAAATTTGATTGTGCGTGATGGTGGAATTCGTGGCCTTGTGATT
TTACTTGAAAAATTAGAGTCAGTAAAAGTGGCTGGCTATACGATTGAAGCTCAAGCTGGTGCAAAATTAAAAGAAGTAAC
ACAAGTGGCACAAGCAAATTCACTGACAGGTTTTGAATTTGCCTGCGGAATTCCAGGTTCAATTGGCGGTGCTGTTTTCA
TGAATGCTGGAGCTTATGGTGGCGAAATTTCTCAAGTTTTGGTAAGTTGCAAAGTTATGGATACTGACGGAAACATTTCG
GTTCTGACTGCAAGTGAAATGCAATTTGGCTACCGTCATTCTGTCATTCGTGACAAAAATTTGGTTGTTTTGTCAGCAAA
ATTTGAACTCCAAGCAGGTGATCCGACTCAAATTCAAAATGAAATGAATCGACTCAATTTCCTGCGCGAAAGTAAGCAAC
CCTTGGAATATCCAAGTTGCGGTTCAGTTTTCAAACGCCCAGTCGGTCATTTTGCTGGACAATTAATCCAAGAAGCTAAT
CTACAAGGTGTACGCATTGGCGGTGTTGAAGTTAGCAAAAAACATGCAGGTTTCATGGTTAATGTTGCAAATGGAAATGC
GACAGATTATGAAAAACTTATCGCACATGTTATTGATAAAGTGAAAGAAAACTCAGGGGTCACTCTTGAACCTGAAGTTA
GAATAATCGGTGAAAAATAA

Upstream 100 bases:

>100_bases
TATCTTCGATAAAGCTAAAGGTTTCTTGAATAAAAAGAAAGTTAAAGCCGAAATTTAAGACAAAATTGTCATCTTTAATA
GAAAATGATAAAATAAGGAT

Downstream 100 bases:

>100_bases
GACAGGATTTTCCTGTCTTTTTCAAATTTCAACTTGATAAATCATCTAATTTAAGCTATAATTAATGGTGTTCTGTGCAT
ATACAGAAGATTTGACCGCT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MIKETDLENIPDLLVKFNEPLSKYTYTKVGGPADILAFPATIEALTELLVKAKSTDTAVTVLGNASNLIVRDGGIRGLVI
LLEKLESVKVAGYTIEAQAGAKLKEVTQVAQANSLTGFEFACGIPGSIGGAVFMNAGAYGGEISQVLVSCKVMDTDGNIS
VLTASEMQFGYRHSVIRDKNLVVLSAKFELQAGDPTQIQNEMNRLNFLRESKQPLEYPSCGSVFKRPVGHFAGQLIQEAN
LQGVRIGGVEVSKKHAGFMVNVANGNATDYEKLIAHVIDKVKENSGVTLEPEVRIIGEK

Sequences:

>Translated_299_residues
MIKETDLENIPDLLVKFNEPLSKYTYTKVGGPADILAFPATIEALTELLVKAKSTDTAVTVLGNASNLIVRDGGIRGLVI
LLEKLESVKVAGYTIEAQAGAKLKEVTQVAQANSLTGFEFACGIPGSIGGAVFMNAGAYGGEISQVLVSCKVMDTDGNIS
VLTASEMQFGYRHSVIRDKNLVVLSAKFELQAGDPTQIQNEMNRLNFLRESKQPLEYPSCGSVFKRPVGHFAGQLIQEAN
LQGVRIGGVEVSKKHAGFMVNVANGNATDYEKLIAHVIDKVKENSGVTLEPEVRIIGEK
>Mature_299_residues
MIKETDLENIPDLLVKFNEPLSKYTYTKVGGPADILAFPATIEALTELLVKAKSTDTAVTVLGNASNLIVRDGGIRGLVI
LLEKLESVKVAGYTIEAQAGAKLKEVTQVAQANSLTGFEFACGIPGSIGGAVFMNAGAYGGEISQVLVSCKVMDTDGNIS
VLTASEMQFGYRHSVIRDKNLVVLSAKFELQAGDPTQIQNEMNRLNFLRESKQPLEYPSCGSVFKRPVGHFAGQLIQEAN
LQGVRIGGVEVSKKHAGFMVNVANGNATDYEKLIAHVIDKVKENSGVTLEPEVRIIGEK

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_LACLA (Q9CGD5)

Other databases:

- EMBL:   AE005176
- PIR:   B86770
- RefSeq:   NP_267318.1
- ProteinModelPortal:   Q9CGD5
- SMR:   Q9CGD5
- GeneID:   1114804
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L173881
- NMPDR:   fig|272623.1.peg.1196
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   LLAC272623:L173881-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32098; Mature: 32098

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 172-172 ACT_SITE 222-222 ACT_SITE 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKETDLENIPDLLVKFNEPLSKYTYTKVGGPADILAFPATIEALTELLVKAKSTDTAVT
CCCCCCCHHHHHHHHHHCCCHHHCEEEECCCCHHEEECCHHHHHHHHHHHHCCCCCCEEE
VLGNASNLIVRDGGIRGLVILLEKLESVKVAGYTIEAQAGAKLKEVTQVAQANSLTGFEF
EEECCCEEEEECCCCCHHHHHHHHHHCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEE
ACGIPGSIGGAVFMNAGAYGGEISQVLVSCKVMDTDGNISVLTASEMQFGYRHSVIRDKN
ECCCCCCCCCEEEEECCCCCCHHHHHHEEEEEEECCCCEEEEEEHHHCCCHHHHHCCCCC
LVVLSAKFELQAGDPTQIQNEMNRLNFLRESKQPLEYPSCGSVFKRPVGHFAGQLIQEAN
EEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LQGVRIGGVEVSKKHAGFMVNVANGNATDYEKLIAHVIDKVKENSGVTLEPEVRIIGEK
CCEEEECCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEECCC
>Mature Secondary Structure
MIKETDLENIPDLLVKFNEPLSKYTYTKVGGPADILAFPATIEALTELLVKAKSTDTAVT
CCCCCCCHHHHHHHHHHCCCHHHCEEEECCCCHHEEECCHHHHHHHHHHHHCCCCCCEEE
VLGNASNLIVRDGGIRGLVILLEKLESVKVAGYTIEAQAGAKLKEVTQVAQANSLTGFEF
EEECCCEEEEECCCCCHHHHHHHHHHCEEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEE
ACGIPGSIGGAVFMNAGAYGGEISQVLVSCKVMDTDGNISVLTASEMQFGYRHSVIRDKN
ECCCCCCCCCEEEEECCCCCCHHHHHHEEEEEEECCCCEEEEEEHHHCCCHHHHHCCCCC
LVVLSAKFELQAGDPTQIQNEMNRLNFLRESKQPLEYPSCGSVFKRPVGHFAGQLIQEAN
EEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LQGVRIGGVEVSKKHAGFMVNVANGNATDYEKLIAHVIDKVKENSGVTLEPEVRIIGEK
CCEEEECCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471