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The map label for this gene is hom

Identifier: 15673141

GI number: 15673141

Start: 1171053

End: 1172339

Strand: Direct

Name: hom

Synonym: L0090

Alternate gene names: 15673141

Gene position: 1171053-1172339 (Clockwise)

Preceding gene: 15673140

Following gene: 15673142

Centisome position: 49.5

GC content: 36.36

Gene sequence:

>1287_bases
ATGACAGTAAATATAGCAATATTGGGGTTTGGGACAGTTGGAACTGGGCTTCCAACTTTAATTTCTGAGAATAAAGAAAA
ACTATCAAAAATTTTAGATGAAGAAATCGTCATTTCAAAAGTTTTGATGAGAGATGAAAAAGCAATTGAAAAAGCTAGAG
CACAGGGTTATCAATATGATTTTGTTCTAACTTTAGAAGAAATTTTGGCTGATTCTGAGATTTCAATTGTTGTTGAGTTG
ATGGGACGGATTGAACCAGCTAAGACCTACATTACGAAAGTGATTAAAGCGGGTAAAAATGTTGTCACAGCCAATAAGGA
TTTACTGGCTGTTCATGGAACTGAATTGCGTGCTTTGGCAGAGAAACATCATGTTGCTCTATATTATGAAGCGGCTGTTG
CTGGTGGGATTCCAATCTTAAGAACTTTAGCCAATTCATTTTCATCAGACAAAATCACACATCTTTTAGGAATTCTTAAT
GGAACAAGTAATTTTATGATGACAAAAATGTCAGAGGAGGCATGGACTTACGACCAATCTTTGGCCAAAGCTCAAGAACT
TGGTTATGCTGAATCTGACCCAACAAATGATGTTGACGGAATTGATGCCAGTTATAAATTAGCGATTTTAAGTGAATTTG
CTTTCGGAATGACGCTAAGTCCTGATCAAATTTCTAAATCTGGCCTCAGAACGATTCAAAAAACTGACGTTGAGATTGCT
CAACAATTTGGCTATGTTTTAAAATTGACAGGTGAAATTAATGAGGTTGAATCAGGAATTTTCGCTGAGGTTAGCCCAAC
TTTTCTTCCCAAAAGTCATCCATTGGCCAGTGTCAATGGTGTTATGAATGCTGTTTTTATTGAATCAGATGGAATTGGGG
ATTCAATGTTCTATGGGGCGGGAGCAGGTCAAAAGCCAACCGCTACGAGTGTTTTAGCTGATATTGTTCGAATTGTTAAA
CGGGAAAAAGATGGAACAATTGGGAAGTCATTTAATGAATACGCACGTCCAACGAGCTTAGCTAATCCTCACGATATTGT
AAATAAATATTATTTTTCCGTTGAAACACCAGATTCAACTGGGCAATTATTGCGCTTGGTGGAGTTATTTACAAGTGAAG
ATGTCTCTTTTGAACAAGTTTTACAACAAAAAGGTGATGGACATCGCGCAGTTGTTGTGATTATCAGTCATCAGATTAAC
CGCGTTCAACTTTTGGCCATTCAAGATAAATTAAAAGAAGAAGTAGATTTTAAATTACTTAATTATTTTAAAGTTTTGGG
GGACTAG

Upstream 100 bases:

>100_bases
TAAATTTTTTTCGATAAAAATGGTATAATATTAAGAAATTGAGCGAAAGTTATTTTTTGAATTATCTTAAAATTTAATTT
TTGTTTGAAAAGGAGAAGTG

Downstream 100 bases:

>100_bases
GAAAATGAAAATTATTGTACCAGCGACATCAGCAAATTTAGGCGCAGGTTTTGATTCAATTGGTATTGCGGTCAACTTGT
ATTTGACAGTGGAAGTACTT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTVNIAILGFGTVGTGLPTLISENKEKLSKILDEEIVISKVLMRDEKAIEKARAQGYQYDFVLTLEEILADSEISIVVEL
MGRIEPAKTYITKVIKAGKNVVTANKDLLAVHGTELRALAEKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILN
GTSNFMMTKMSEEAWTYDQSLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLSPDQISKSGLRTIQKTDVEIA
QQFGYVLKLTGEINEVESGIFAEVSPTFLPKSHPLASVNGVMNAVFIESDGIGDSMFYGAGAGQKPTATSVLADIVRIVK
REKDGTIGKSFNEYARPTSLANPHDIVNKYYFSVETPDSTGQLLRLVELFTSEDVSFEQVLQQKGDGHRAVVVIISHQIN
RVQLLAIQDKLKEEVDFKLLNYFKVLGD

Sequences:

>Translated_428_residues
MTVNIAILGFGTVGTGLPTLISENKEKLSKILDEEIVISKVLMRDEKAIEKARAQGYQYDFVLTLEEILADSEISIVVEL
MGRIEPAKTYITKVIKAGKNVVTANKDLLAVHGTELRALAEKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILN
GTSNFMMTKMSEEAWTYDQSLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLSPDQISKSGLRTIQKTDVEIA
QQFGYVLKLTGEINEVESGIFAEVSPTFLPKSHPLASVNGVMNAVFIESDGIGDSMFYGAGAGQKPTATSVLADIVRIVK
REKDGTIGKSFNEYARPTSLANPHDIVNKYYFSVETPDSTGQLLRLVELFTSEDVSFEQVLQQKGDGHRAVVVIISHQIN
RVQLLAIQDKLKEEVDFKLLNYFKVLGD
>Mature_427_residues
TVNIAILGFGTVGTGLPTLISENKEKLSKILDEEIVISKVLMRDEKAIEKARAQGYQYDFVLTLEEILADSEISIVVELM
GRIEPAKTYITKVIKAGKNVVTANKDLLAVHGTELRALAEKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNG
TSNFMMTKMSEEAWTYDQSLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLSPDQISKSGLRTIQKTDVEIAQ
QFGYVLKLTGEINEVESGIFAEVSPTFLPKSHPLASVNGVMNAVFIESDGIGDSMFYGAGAGQKPTATSVLADIVRIVKR
EKDGTIGKSFNEYARPTSLANPHDIVNKYYFSVETPDSTGQLLRLVELFTSEDVSFEQVLQQKGDGHRAVVVIISHQINR
VQLLAIQDKLKEEVDFKLLNYFKVLGD

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=27.3092369477912, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHOM_LACLA (Q9CGD8)

Other databases:

- EMBL:   AE005176
- PIR:   G86769
- RefSeq:   NP_267315.1
- ProteinModelPortal:   Q9CGD8
- GeneID:   1114801
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0090
- NMPDR:   fig|272623.1.peg.1193
- HOGENOM:   HBG527379
- OMA:   EISIVIE
- ProtClustDB:   PRK06349
- BioCyc:   LLAC272623:L0090-MONOMER
- BRENDA:   1.1.1.3
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000098

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3

EC number: =1.1.1.3

Molecular weight: Translated: 46921; Mature: 46790

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01042 HOMOSER_DHGENASE; PS00697 DNA_LIGASE_A1

Important sites: ACT_SITE 206-206 BINDING 106-106 BINDING 191-191

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNIAILGFGTVGTGLPTLISENKEKLSKILDEEIVISKVLMRDEKAIEKARAQGYQYD
CEEEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FVLTLEEILADSEISIVVELMGRIEPAKTYITKVIKAGKNVVTANKDLLAVHGTELRALA
EEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCEEEECCHHHHHHH
EKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTSNFMMTKMSEEAWTYDQS
HHCCEEEEEEHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
LAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLSPDQISKSGLRTIQKTDVEIA
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QQFGYVLKLTGEINEVESGIFAEVSPTFLPKSHPLASVNGVMNAVFIESDGIGDSMFYGA
HHCCEEEEEECCHHHHCCCCEEECCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCEECC
GAGQKPTATSVLADIVRIVKREKDGTIGKSFNEYARPTSLANPHDIVNKYYFSVETPDST
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHEEEEEECCCCH
GQLLRLVELFTSEDVSFEQVLQQKGDGHRAVVVIISHQINRVQLLAIQDKLKEEVDFKLL
HHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHH
NYFKVLGD
HHHHHHCC
>Mature Secondary Structure 
TVNIAILGFGTVGTGLPTLISENKEKLSKILDEEIVISKVLMRDEKAIEKARAQGYQYD
EEEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FVLTLEEILADSEISIVVELMGRIEPAKTYITKVIKAGKNVVTANKDLLAVHGTELRALA
EEEEHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEECCCCEEEECCHHHHHHH
EKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTSNFMMTKMSEEAWTYDQS
HHCCEEEEEEHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
LAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLSPDQISKSGLRTIQKTDVEIA
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QQFGYVLKLTGEINEVESGIFAEVSPTFLPKSHPLASVNGVMNAVFIESDGIGDSMFYGA
HHCCEEEEEECCHHHHCCCCEEECCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCEECC
GAGQKPTATSVLADIVRIVKREKDGTIGKSFNEYARPTSLANPHDIVNKYYFSVETPDST
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCHHHHHHHEEEEEECCCCH
GQLLRLVELFTSEDVSFEQVLQQKGDGHRAVVVIISHQINRVQLLAIQDKLKEEVDFKLL
HHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHH
NYFKVLGD
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471