Click here to switch to the map view.

The map label for this gene is hemN

Identifier: 15673121

GI number: 15673121

Start: 1153284

End: 1154423

Strand: Direct

Name: hemN

Synonym: L0193

Alternate gene names: 15673121

Gene position: 1153284-1154423 (Clockwise)

Preceding gene: 15673120

Following gene: 15673122

Centisome position: 48.75

GC content: 32.63

Gene sequence:

>1140_bases
ATGTTGCAAAAACCTAATTCGGCTTATTTTCACATTCCTTTTTGTTCTCATATTTGTTATTATTGCGATTTTGCTAAAGT
ACTGATGACAGGACAGCCGATTGATGCTTATATTGAATCGCTCATAGAAGAATTTCAAAGTTTTGAGATAGAAAAATTAA
GAACAATCTATATTGGTGGTGGAACGCCCAGCGTTTTATCAGCCCAACAACTTGAACGTTTACTGACAGCGATTGCTGAA
CAGTTAGATTTAGAAGTTTTGGAAGAATTTACTGTTGAAGCAAATCCGGGGGATTTATCAGATGAGGTTATTAAAGTTTT
GGCTGATTCAGCAGTAAATCGAATTTCATTAGGTGTCCAAACTTTTAATAATGCTTTGCTCAAAAAAATCGGGCGGACAC
ATACAGAAGTTCAAGTCTATGATTCAGTTGAAAGACTGAAAAAAGCTGGATTTGAAAATATTACGATTGATTTAATCTAT
GCTTTACCTGGGCAAACGATGGAGATGGTTAAGTCAGATGTTGAAAAATTTTTAGAATTAAAACTACCACATGTGGCATT
ATATAGTCTTATTTTAGAGGACCATACAGTTTTTATGAATCGACAACGTCGTGGTCTTTTACGCCTACCAAGTGAAGATA
AAAATGCGGACATGTATGAATATATCATGGATATTTTAGCTAAAAATGGTTATAATCACTATGAAGTTTCAAATTTTGGC
TTACCAGGATTTGAGAGCAAACATAATATAACTTATTGGGATAATGAGGAATATTATGGAATTGGCGCTGGAGCGTCAGG
ATATTTAGCAGGGATTCGTTATAAAAATCTTGGTCCAGTTCATCATTACCTTAAAGCTGCTCCAACTGAAAAAAGGATAA
ATGAAGAAGTTTTAAGTAAAAAATCTCAAATAGAAGAAGAAATGTTCTTAGGTCTTCGGAAAAAATCGGGAGTTTTGGTT
GAGAAGTTTGAAAATAAATTCAAGTGTTCATTTGAAAAATTATACGGTGAACAAATCACAGAACTTATTAATCAAAAATT
ATTATATAATGATAGACAAAGAATCCATATGACAGACAAAGGTTTTGAGTTGGGGAATAATGTCTTTGAGAAATTTTTGC
TCGATGATATTAATTTTTAA

Upstream 100 bases:

>100_bases
TAGGTCAAGTATTTGTGATTTTTATTGGTAAGATTAATTTTAGGGTTAATCCTCTCACTATCTTTCATTGAATAGGAAAA
ATTTTTGAAGGGACTTATAA

Downstream 100 bases:

>100_bases
TGCTATCGTGATGAATTTTTGTGAAAGTTATGTTACAATATAATTAATGAAACCTAAAATGAGACGTAAACTTAAAAAAA
TGGGAGCTTTTATCTTTACA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MLQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPIDAYIESLIEEFQSFEIEKLRTIYIGGGTPSVLSAQQLERLLTAIAE
QLDLEVLEEFTVEANPGDLSDEVIKVLADSAVNRISLGVQTFNNALLKKIGRTHTEVQVYDSVERLKKAGFENITIDLIY
ALPGQTMEMVKSDVEKFLELKLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAKNGYNHYEVSNFG
LPGFESKHNITYWDNEEYYGIGAGASGYLAGIRYKNLGPVHHYLKAAPTEKRINEEVLSKKSQIEEEMFLGLRKKSGVLV
EKFENKFKCSFEKLYGEQITELINQKLLYNDRQRIHMTDKGFELGNNVFEKFLLDDINF

Sequences:

>Translated_379_residues
MLQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPIDAYIESLIEEFQSFEIEKLRTIYIGGGTPSVLSAQQLERLLTAIAE
QLDLEVLEEFTVEANPGDLSDEVIKVLADSAVNRISLGVQTFNNALLKKIGRTHTEVQVYDSVERLKKAGFENITIDLIY
ALPGQTMEMVKSDVEKFLELKLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAKNGYNHYEVSNFG
LPGFESKHNITYWDNEEYYGIGAGASGYLAGIRYKNLGPVHHYLKAAPTEKRINEEVLSKKSQIEEEMFLGLRKKSGVLV
EKFENKFKCSFEKLYGEQITELINQKLLYNDRQRIHMTDKGFELGNNVFEKFLLDDINF
>Mature_379_residues
MLQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPIDAYIESLIEEFQSFEIEKLRTIYIGGGTPSVLSAQQLERLLTAIAE
QLDLEVLEEFTVEANPGDLSDEVIKVLADSAVNRISLGVQTFNNALLKKIGRTHTEVQVYDSVERLKKAGFENITIDLIY
ALPGQTMEMVKSDVEKFLELKLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAKNGYNHYEVSNFG
LPGFESKHNITYWDNEEYYGIGAGASGYLAGIRYKNLGPVHHYLKAAPTEKRINEEVLSKKSQIEEEMFLGLRKKSGVLV
EKFENKFKCSFEKLYGEQITELINQKLLYNDRQRIHMTDKGFELGNNVFEKFLLDDINF

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=263, Percent_Identity=31.1787072243346, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1789325, Length=268, Percent_Identity=35.4477611940299, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI87082341, Length=245, Percent_Identity=27.7551020408163, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43553; Mature: 43553

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPIDAYIESLIEEFQSFEIEKLRTIYIGG
CCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEECC
GTPSVLSAQQLERLLTAIAEQLDLEVLEEFTVEANPGDLSDEVIKVLADSAVNRISLGVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TFNNALLKKIGRTHTEVQVYDSVERLKKAGFENITIDLIYALPGQTMEMVKSDVEKFLEL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
KLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAKNGYNHYEVSNFG
CCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCEEECCCC
LPGFESKHNITYWDNEEYYGIGAGASGYLAGIRYKNLGPVHHYLKAAPTEKRINEEVLSK
CCCCCCCCCEEEECCCCEEEECCCCCCCEECCEECCCCHHHHHHHCCCCHHHHHHHHHHH
KSQIEEEMFLGLRKKSGVLVEKFENKFKCSFEKLYGEQITELINQKLLYNDRQRIHMTDK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GFELGNNVFEKFLLDDINF
CHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLQKPNSAYFHIPFCSHICYYCDFAKVLMTGQPIDAYIESLIEEFQSFEIEKLRTIYIGG
CCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEECC
GTPSVLSAQQLERLLTAIAEQLDLEVLEEFTVEANPGDLSDEVIKVLADSAVNRISLGVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TFNNALLKKIGRTHTEVQVYDSVERLKKAGFENITIDLIYALPGQTMEMVKSDVEKFLEL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHH
KLPHVALYSLILEDHTVFMNRQRRGLLRLPSEDKNADMYEYIMDILAKNGYNHYEVSNFG
CCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCEEECCCC
LPGFESKHNITYWDNEEYYGIGAGASGYLAGIRYKNLGPVHHYLKAAPTEKRINEEVLSK
CCCCCCCCCEEEECCCCEEEECCCCCCCEECCEECCCCHHHHHHHCCCCHHHHHHHHHHH
KSQIEEEMFLGLRKKSGVLVEKFENKFKCSFEKLYGEQITELINQKLLYNDRQRIHMTDK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GFELGNNVFEKFLLDDINF
CHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]