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The map label for this gene is murQ

Identifier: 15673112

GI number: 15673112

Start: 1144591

End: 1145484

Strand: Direct

Name: murQ

Synonym: L144334

Alternate gene names: 15673112

Gene position: 1144591-1145484 (Clockwise)

Preceding gene: 15673111

Following gene: 15673113

Centisome position: 48.39

GC content: 36.58

Gene sequence:

>894_bases
ATGATTGATTTATCAACACTAACAACAGAACGACGAAATAACGAAACTTTTAACCTTGACCAAATGACTGTCGCAGAAGC
GCTTATTAAAATGAATAATGAAGATAAAAAAGTTGCTTTTGCAGTTGAAGAAGCACTTCCAAATATTGAACCAGTTATTT
CATCAGCGATTGAAGCTTTTAACAAAGGTGGCCGTTTGATTTATATGGGTGCTGGAACAAGTGGTCGTTTAGGTGTACTT
GATGCCGCTGAATGTGTCCCAACCTTTGGCGTACCAGCTACCCAAGTGATTGGTTTAATTGCCGGTGGTGACAAAGCAAT
GACGGTTTCTGTCGAAGGGGCTGAGGATAGTCTTGAACTTGGAAGACAAGATTTGATTGATTTGAAGTTGAATGAGAACG
ACCTTGTTTTAGGAATCGCTGCCAGTGGTCGGACTCCATATGTAATTGGAGCTTTAGATTACGCTAAAGAAATTGGTGCT
AAAACGGCAAGTCTTTCTTGTAATCTTAATGCTGAAATTTCAAAACATGCCGAATTTCCAATTGAAGTTGATTGTGGACC
AGAATTTTTAACAGGCTCAACAAGATTAAAATCGGGAACAGCTCAAAAATTAATTTTGAATATGATTTCAACAATTTCAA
TGATTGGGATTGGTAAAGTTTATAATAACTTGATGGTGGATGTTAAACCAACAAATGAAAAATTAGTTGAGCGTAGTAAA
CGCATCATTATGCAAGCGACAGATTGTACTTATGAAGAAGCCGAAGAAAAATTCATTGAAGCCGATCAAGATGTTAAACT
TGCAATTGTCATGTTATTAACTGATTGTGCAGCAGAAGAAGGAAAAACCAAGCTTGTTAGAGCAAATGGTTTTGTGAAAA
ATACTCTGAATTAA

Upstream 100 bases:

>100_bases
AAAAAAGTAAATGTTGTGGGAAATATTATTAAAGAAGATTTAGAACTTATTTCTTTTATTGGCCCAGGACAAAAATTTAA
AATAGAAAAAGAGAAAAATA

Downstream 100 bases:

>100_bases
GAATTTACCTTTTAAGGTAGGAGAAGGAGCAAAAATGGCAGAAGAAAAAATAGCTCGTATTGCACGTGAGATTTATGAAA
ATGTTGGTGGAACACAAAAT

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIDLSTLTTERRNNETFNLDQMTVAEALIKMNNEDKKVAFAVEEALPNIEPVISSAIEAFNKGGRLIYMGAGTSGRLGVL
DAAECVPTFGVPATQVIGLIAGGDKAMTVSVEGAEDSLELGRQDLIDLKLNENDLVLGIAASGRTPYVIGALDYAKEIGA
KTASLSCNLNAEISKHAEFPIEVDCGPEFLTGSTRLKSGTAQKLILNMISTISMIGIGKVYNNLMVDVKPTNEKLVERSK
RIIMQATDCTYEEAEEKFIEADQDVKLAIVMLLTDCAAEEGKTKLVRANGFVKNTLN

Sequences:

>Translated_297_residues
MIDLSTLTTERRNNETFNLDQMTVAEALIKMNNEDKKVAFAVEEALPNIEPVISSAIEAFNKGGRLIYMGAGTSGRLGVL
DAAECVPTFGVPATQVIGLIAGGDKAMTVSVEGAEDSLELGRQDLIDLKLNENDLVLGIAASGRTPYVIGALDYAKEIGA
KTASLSCNLNAEISKHAEFPIEVDCGPEFLTGSTRLKSGTAQKLILNMISTISMIGIGKVYNNLMVDVKPTNEKLVERSK
RIIMQATDCTYEEAEEKFIEADQDVKLAIVMLLTDCAAEEGKTKLVRANGFVKNTLN
>Mature_297_residues
MIDLSTLTTERRNNETFNLDQMTVAEALIKMNNEDKKVAFAVEEALPNIEPVISSAIEAFNKGGRLIYMGAGTSGRLGVL
DAAECVPTFGVPATQVIGLIAGGDKAMTVSVEGAEDSLELGRQDLIDLKLNENDLVLGIAASGRTPYVIGALDYAKEIGA
KTASLSCNLNAEISKHAEFPIEVDCGPEFLTGSTRLKSGTAQKLILNMISTISMIGIGKVYNNLMVDVKPTNEKLVERSK
RIIMQATDCTYEEAEEKFIEADQDVKLAIVMLLTDCAAEEGKTKLVRANGFVKNTLN

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=296, Percent_Identity=48.6486486486487, Blast_Score=276, Evalue=9e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_LACLA (Q9CGG6)

Other databases:

- EMBL:   AE005176
- PIR:   B86766
- RefSeq:   NP_267286.1
- HSSP:   P44862
- ProteinModelPortal:   Q9CGG6
- SMR:   Q9CGG6
- GeneID:   1114770
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L144334
- NMPDR:   fig|272623.1.peg.1162
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK05441
- BioCyc:   LLAC272623:L144334-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 31982; Mature: 31982

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 84-84 ACT_SITE 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLSTLTTERRNNETFNLDQMTVAEALIKMNNEDKKVAFAVEEALPNIEPVISSAIEAF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCHHHHHHHHHHHH
NKGGRLIYMGAGTSGRLGVLDAAECVPTFGVPATQVIGLIAGGDKAMTVSVEGAEDSLEL
CCCCEEEEEECCCCCCEECCCHHHHCCCCCCCHHHHEEEEECCCEEEEEEEECCCHHHHC
GRQDLIDLKLNENDLVLGIAASGRTPYVIGALDYAKEIGAKTASLSCNLNAEISKHAEFP
CCCCEEEEEECCCCEEEEEECCCCCCEEEEHHHHHHHHCCCEEEEEECCCCCHHHCCCCC
IEVDCGPEFLTGSTRLKSGTAQKLILNMISTISMIGIGKVYNNLMVDVKPTNEKLVERSK
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHH
RIIMQATDCTYEEAEEKFIEADQDVKLAIVMLLTDCAAEEGKTKLVRANGFVKNTLN
HEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEECCCC
>Mature Secondary Structure
MIDLSTLTTERRNNETFNLDQMTVAEALIKMNNEDKKVAFAVEEALPNIEPVISSAIEAF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCHHHHHHHHHHHH
NKGGRLIYMGAGTSGRLGVLDAAECVPTFGVPATQVIGLIAGGDKAMTVSVEGAEDSLEL
CCCCEEEEEECCCCCCEECCCHHHHCCCCCCCHHHHEEEEECCCEEEEEEEECCCHHHHC
GRQDLIDLKLNENDLVLGIAASGRTPYVIGALDYAKEIGAKTASLSCNLNAEISKHAEFP
CCCCEEEEEECCCCEEEEEECCCCCCEEEEHHHHHHHHCCCEEEEEECCCCCHHHCCCCC
IEVDCGPEFLTGSTRLKSGTAQKLILNMISTISMIGIGKVYNNLMVDVKPTNEKLVERSK
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHH
RIIMQATDCTYEEAEEKFIEADQDVKLAIVMLLTDCAAEEGKTKLVRANGFVKNTLN
HEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471