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The map label for this gene is ldhX

Identifier: 15673110

GI number: 15673110

Start: 1142407

End: 1143378

Strand: Direct

Name: ldhX

Synonym: L142159

Alternate gene names: 15673110

Gene position: 1142407-1143378 (Clockwise)

Preceding gene: 15673109

Following gene: 15673111

Centisome position: 48.29

GC content: 37.35

Gene sequence:

>972_bases
ATGAAAATTAATAACAAAAAAGTTGTAATTGTTGGAGCTGGAGCCGTAGGGAGTACTTATGCTCATAATTTAGTTGTTGA
TGATTTAGCAGACGAAATTGCAATAATAAATACCAACAAAAGTAAAGCTTCAGCCAACAGTTTGGACTTGCTTCATGCGC
TTCCCTATTTAAATGCAGCTCCTAAAAACATTTATGCTGCTGATTATTCAGATGTTTCTGATGCAGATATTGTTGTTTTG
TCTGCCAATGCTCCATCAGCAACTTTCGGAAAAAATCCAGATCGCCTACAGTTATTAGAAAATAAGGTCGAAATGATTCG
TGATATAACTCGTAAAACAATGGATGCAGGTTTTGATGGTATCTTCTTGGTCGCATCAAATCCAGTTGATGTCCTTGCCC
AAGTTGTTGCAGAAGTATCTGGCTTGCCTAAACATCGTGTGATAGGGACAGGAACGCTTTTAGAAACTAGTCGGATGCGC
CAAATCGTTGCAGAAAAACTCCAAATTAATCCTAAAAGTATTCATGGATATGTTTTAGCTGAGCATGGGAAATCAAGTTT
TGCCGCTTGGTCAAACGTGACAGTCGGTGCGATTCCATTAACAACGTGGCTCAAAAAATATCCTAATCCAGAGTTTCCAA
CCTTCGATGAAATTGATCAAGAAATTCGTGAAGTAGGTTTGGATATCTTTATGCAAAAAGGAAATACCTCTTACGGAATC
GCTGCTTCATTAGCTCGTTTGACAAGAGCAATTTTTAGAAACGAAAGCGTGATTCTGCCAGTTTCTGCCTATTTGACAGG
AGAGTATGGTCAGTTCGATTTATATACAGGAAGTCCTGCAATTATTGATAGAACAGGTGTTCGAGCAGTCCTAGAGTTAG
AATTAACTCAAGAAGAGCAAGAAAAATTTAAAGCTTCAACGGTTCTTCTTAAAGAGAATTTTGATTCAATTAAAGAAAAA
TGTACTTTGTAA

Upstream 100 bases:

>100_bases
TAAATAAACTGTAAGTAAATTAGGAAAAGTGATTTGGAAAGGGAGTAGAAAAACAACGTGAGTCAAAATGAGATCCGCTG
TTTTTTTATGATGAAAAGAG

Downstream 100 bases:

>100_bases
ATATAATAAAAAGAATAAAGAAATTTATTCTTTTTATTATACAAACCAATGAAATAATATTTCAAAATAAAAAAAGATTA
AATTGATACTTGAAATAATA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 3

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKINNKKVVIVGAGAVGSTYAHNLVVDDLADEIAIINTNKSKASANSLDLLHALPYLNAAPKNIYAADYSDVSDADIVVL
SANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDGIFLVASNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMR
QIVAEKLQINPKSIHGYVLAEHGKSSFAAWSNVTVGAIPLTTWLKKYPNPEFPTFDEIDQEIREVGLDIFMQKGNTSYGI
AASLARLTRAIFRNESVILPVSAYLTGEYGQFDLYTGSPAIIDRTGVRAVLELELTQEEQEKFKASTVLLKENFDSIKEK
CTL

Sequences:

>Translated_323_residues
MKINNKKVVIVGAGAVGSTYAHNLVVDDLADEIAIINTNKSKASANSLDLLHALPYLNAAPKNIYAADYSDVSDADIVVL
SANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDGIFLVASNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMR
QIVAEKLQINPKSIHGYVLAEHGKSSFAAWSNVTVGAIPLTTWLKKYPNPEFPTFDEIDQEIREVGLDIFMQKGNTSYGI
AASLARLTRAIFRNESVILPVSAYLTGEYGQFDLYTGSPAIIDRTGVRAVLELELTQEEQEKFKASTVLLKENFDSIKEK
CTL
>Mature_323_residues
MKINNKKVVIVGAGAVGSTYAHNLVVDDLADEIAIINTNKSKASANSLDLLHALPYLNAAPKNIYAADYSDVSDADIVVL
SANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDGIFLVASNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMR
QIVAEKLQINPKSIHGYVLAEHGKSSFAAWSNVTVGAIPLTTWLKKYPNPEFPTFDEIDQEIREVGLDIFMQKGNTSYGI
AASLARLTRAIFRNESVILPVSAYLTGEYGQFDLYTGSPAIIDRTGVRAVLELELTQEEQEKFKASTVLLKENFDSIKEK
CTL

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family

Homologues:

Organism=Homo sapiens, GI291575128, Length=309, Percent_Identity=34.6278317152104, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI4557032, Length=309, Percent_Identity=34.6278317152104, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI5031857, Length=307, Percent_Identity=32.2475570032573, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI260099723, Length=307, Percent_Identity=32.2475570032573, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI9257228, Length=307, Percent_Identity=33.5504885993485, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI4504973, Length=307, Percent_Identity=33.5504885993485, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI47059044, Length=321, Percent_Identity=31.4641744548287, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI221136809, Length=321, Percent_Identity=31.4641744548287, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI15082234, Length=320, Percent_Identity=30.3125, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI260099725, Length=196, Percent_Identity=35.2040816326531, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI260099727, Length=196, Percent_Identity=35.2040816326531, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI207028494, Length=216, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI103472011, Length=303, Percent_Identity=21.7821782178218, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI103472015, Length=186, Percent_Identity=23.6559139784946, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17535107, Length=297, Percent_Identity=31.3131313131313, Blast_Score=150, Evalue=7e-37,
Organism=Drosophila melanogaster, GI45550422, Length=309, Percent_Identity=32.0388349514563, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17136226, Length=310, Percent_Identity=30.3225806451613, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LDH3_LACLA (Q9CGG8)

Other databases:

- EMBL:   AE005176
- PIR:   H86765
- RefSeq:   NP_267284.1
- ProteinModelPortal:   Q9CGG8
- SMR:   Q9CGG8
- GeneID:   1114768
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L142159
- NMPDR:   fig|272623.1.peg.1160
- HOGENOM:   HBG566126
- OMA:   INDYHEL
- ProtClustDB:   CLSK697595
- BioCyc:   LLAC272623:L142159-MONOMER
- BRENDA:   1.1.1.27
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0006096
- HAMAP:   MF_00488
- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.90.110.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000102
- PRINTS:   PR00086
- TIGRFAMs:   TIGR01771

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C

EC number: =1.1.1.27

Molecular weight: Translated: 35272; Mature: 35272

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00064 L_LDH

Important sites: ACT_SITE 182-182 BINDING 95-95 BINDING 127-127 BINDING 158-158 BINDING 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINNKKVVIVGAGAVGSTYAHNLVVDDLADEIAIINTNKSKASANSLDLLHALPYLNAA
CCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCC
PKNIYAADYSDVSDADIVVLSANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDG
CCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
IFLVASNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMRQIVAEKLQINPKSIHGYVLA
EEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
EHGKSSFAAWSNVTVGAIPLTTWLKKYPNPEFPTFDEIDQEIREVGLDIFMQKGNTSYGI
ECCCCCHHECCCCEECEEHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHEEEECCCCCHHH
AASLARLTRAIFRNESVILPVSAYLTGEYGQFDLYTGSPAIIDRTGVRAVLELELTQEEQ
HHHHHHHHHHHHCCCCEEEEEEHEEECCCCEEEEECCCCCEEECCCCEEEEEEEECHHHH
EKFKASTVLLKENFDSIKEKCTL
HHHHHHHEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MKINNKKVVIVGAGAVGSTYAHNLVVDDLADEIAIINTNKSKASANSLDLLHALPYLNAA
CCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCC
PKNIYAADYSDVSDADIVVLSANAPSATFGKNPDRLQLLENKVEMIRDITRKTMDAGFDG
CCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
IFLVASNPVDVLAQVVAEVSGLPKHRVIGTGTLLETSRMRQIVAEKLQINPKSIHGYVLA
EEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
EHGKSSFAAWSNVTVGAIPLTTWLKKYPNPEFPTFDEIDQEIREVGLDIFMQKGNTSYGI
ECCCCCHHECCCCEECEEHHHHHHHHCCCCCCCCHHHHHHHHHHHCHHEEEECCCCCHHH
AASLARLTRAIFRNESVILPVSAYLTGEYGQFDLYTGSPAIIDRTGVRAVLELELTQEEQ
HHHHHHHHHHHHCCCCEEEEEEHEEECCCCEEEEECCCCCEEECCCCEEEEEEEECHHHH
EKFKASTVLLKENFDSIKEKCTL
HHHHHHHEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471