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The map label for this gene is ylaF

Identifier: 15673082

GI number: 15673082

Start: 1107724

End: 1109211

Strand: Direct

Name: ylaF

Synonym: L107468

Alternate gene names: 15673082

Gene position: 1107724-1109211 (Clockwise)

Preceding gene: 15673080

Following gene: 15673083

Centisome position: 46.83

GC content: 37.16

Gene sequence:

>1488_bases
ATGGGAGAAAAAATTATGCCACATCTATATCAAGACGACAGTCTTACATTACATACGGACTTATATCAAATTAATATGAT
GCAAACTTACTTTGAGCTTGGACGACATCAGCGTCAGGCGGTCTTTGAGGTTTTTTTCCGTGAGATGCCCTTTAAAAATG
GTTATGCTGTTTTTGCTGGTTTAGAAAGAATGGTTGATTATTTAAAGAATCTTAAATTCTCGGAAACAGATATTGCCTAT
TTGCGTGAATTAGATTATCCGGAAGATTTTCTAAATTATTTAAAAGAATTGCGTTTTACAGGAACAGTTAGAGCGATGCA
AGAAGGACAACTTGCTTTTGCTAACGAACCTTTAGTGCAGGTTGAAGGTTCGCTTGCGGAATGTCAGTTGGTCGAAACAG
CTATTCTTAATATTATAAATTTCCAAACTTTGATTGCTACTAAAGCTGCTCGTATCAAATCTGTAATTGGGGATGACCCT
TTGTTGGAATTTGGGACAAGACGCGCTCAAGAAATGGATGCAGCCATTTGGGGAACACGAGCAGCAATCATTGGTGGTGC
TGATGCGACATCAAACGTTCGTGCAGCTAAAATCTTTGGTTTGAAGGCTAGTGGAACACATGCTCATGCTTTGGTTCAAT
CTTATGGAAATGATTATGAGGCTTTTAAAGCATACGCACAGACACATAAAGATTGTGTCTTCCTTGTGGATACTTATGAT
ACTTTAAGAGTTGGAGTTCCTTCAGCGATTAAAGTGGCGCGTGAATTTGGCGATAAAATTAATTTCCAAGGTGTACGAAT
TGATTCTGGAGATATGGCCTATATCTCGAAAAAAGTTCGTCAGCAACTTGATGAAGCAGGATTTACTGATGCAAAAATCT
ACGCTTCAAATGATTTAGATGAAAACACAATTTTAAGTTTAAAAATGCAAAAAGCAAAAATTGATGTTTGGGGAGTTGGA
ACTAAATTAATTACGGCTTATGATCAGCCAGCGCTTGGTGCAGTTTATAAATTAGTATCTATGGAAGATGAAAGTGGTCA
AATGCAGGATACCATTAAACTTTCAAGTAATGCTGAAAAAGTTTCTACACCAGGTAAAAAACAAGTTTGGCGAATCACCA
AAAAAGCAGATGGCAAATCAGAGGGGGATTATATTACATTTTCTGATGAACGCCCAGATGTAGCAGAAGAAATTTACATG
TTCCACCCGCTTTATACCTACATCAATAAAAATGTGCGAGACTTCAATGCCAATCCACTTTTGAAAGATATTTTTGTGGA
CGGCGAATTGATTTATGGATTGCCAAGCTTGCAAGAAATTAAAGAATTTGCTCGTGAAAACCTTGAGGAACTTTGGGATG
AATATAAACGTGATTTGAATCCTCAACCTTACCCAGTAGATTTGTCACAAGAATTATGGAATCATAAAATGCGCCTAATT
TCACAGGTGCGTACAACAGTATCAATGACGAGATTGGATGATGAATGA

Upstream 100 bases:

>100_bases
TTGTATAATTATAAAGGGTTCCCAGTACAAATTTAGGGCAAAATTTGATAAAATAAAGATTAGAATTGCGTTAAAATCGG
TATGATTAGCGGAAGTGAAT

Downstream 100 bases:

>100_bases
TGAGAATAAGACGAATAGACCTCTGTGATGCAAGACTTTTCTGGGATGTCCAAAAGCAATTGGATACAGAAAGTAAGTTC
ATGATGCTTGAACCAGAGGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MGEKIMPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRQAVFEVFFREMPFKNGYAVFAGLERMVDYLKNLKFSETDIAY
LRELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGDDP
LLEFGTRRAQEMDAAIWGTRAAIIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYD
TLRVGVPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTILSLKMQKAKIDVWGVG
TKLITAYDQPALGAVYKLVSMEDESGQMQDTIKLSSNAEKVSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYM
FHPLYTYINKNVRDFNANPLLKDIFVDGELIYGLPSLQEIKEFARENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLI
SQVRTTVSMTRLDDE

Sequences:

>Translated_495_residues
MGEKIMPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRQAVFEVFFREMPFKNGYAVFAGLERMVDYLKNLKFSETDIAY
LRELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGDDP
LLEFGTRRAQEMDAAIWGTRAAIIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYD
TLRVGVPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTILSLKMQKAKIDVWGVG
TKLITAYDQPALGAVYKLVSMEDESGQMQDTIKLSSNAEKVSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYM
FHPLYTYINKNVRDFNANPLLKDIFVDGELIYGLPSLQEIKEFARENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLI
SQVRTTVSMTRLDDE
>Mature_494_residues
GEKIMPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRQAVFEVFFREMPFKNGYAVFAGLERMVDYLKNLKFSETDIAYL
RELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQVEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGDDPL
LEFGTRRAQEMDAAIWGTRAAIIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYDT
LRVGVPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLDENTILSLKMQKAKIDVWGVGT
KLITAYDQPALGAVYKLVSMEDESGQMQDTIKLSSNAEKVSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMF
HPLYTYINKNVRDFNANPLLKDIFVDGELIYGLPSLQEIKEFARENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLIS
QVRTTVSMTRLDDE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=518, Percent_Identity=31.4671814671815, Blast_Score=244, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71997952, Length=536, Percent_Identity=37.1268656716418, Blast_Score=311, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI71997947, Length=531, Percent_Identity=37.2881355932203, Blast_Score=308, Evalue=3e-84,
Organism=Caenorhabditis elegans, GI71997955, Length=216, Percent_Identity=43.5185185185185, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=35.4527938342967, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI161076680, Length=227, Percent_Identity=40.0881057268723, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24581595, Length=227, Percent_Identity=40.0881057268723, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28574709, Length=227, Percent_Identity=40.0881057268723, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24581593, Length=227, Percent_Identity=40.0881057268723, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24581591, Length=227, Percent_Identity=40.0881057268723, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56349; Mature: 56217

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKIMPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRQAVFEVFFREMPFKNGYAVFAG
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LERMVDYLKNLKFSETDIAYLRELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQ
HHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEE
VEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGDDPLLEFGTRRAQEMDAAIWGTR
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
AAIIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYD
EEEEECCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCC
TLRVGVPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLD
HHHCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
ENTILSLKMQKAKIDVWGVGTKLITAYDQPALGAVYKLVSMEDESGQMQDTIKLSSNAEK
CCEEEEEEEEEEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHEEECCCCHH
VSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLYTYINKNVRDFNANPL
HCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LKDIFVDGELIYGLPSLQEIKEFARENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLI
HHHHEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
SQVRTTVSMTRLDDE
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
GEKIMPHLYQDDSLTLHTDLYQINMMQTYFELGRHQRQAVFEVFFREMPFKNGYAVFAG
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LERMVDYLKNLKFSETDIAYLRELDYPEDFLNYLKELRFTGTVRAMQEGQLAFANEPLVQ
HHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEE
VEGSLAECQLVETAILNIINFQTLIATKAARIKSVIGDDPLLEFGTRRAQEMDAAIWGTR
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
AAIIGGADATSNVRAAKIFGLKASGTHAHALVQSYGNDYEAFKAYAQTHKDCVFLVDTYD
EEEEECCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCC
TLRVGVPSAIKVAREFGDKINFQGVRIDSGDMAYISKKVRQQLDEAGFTDAKIYASNDLD
HHHCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
ENTILSLKMQKAKIDVWGVGTKLITAYDQPALGAVYKLVSMEDESGQMQDTIKLSSNAEK
CCEEEEEEEEEEEEEEEECCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHEEECCCCHH
VSTPGKKQVWRITKKADGKSEGDYITFSDERPDVAEEIYMFHPLYTYINKNVRDFNANPL
HCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
LKDIFVDGELIYGLPSLQEIKEFARENLEELWDEYKRDLNPQPYPVDLSQELWNHKMRLI
HHHHEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
SQVRTTVSMTRLDDE
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]