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The map label for this gene is hrcA

Identifier: 15672934

GI number: 15672934

Start: 976778

End: 977821

Strand: Direct

Name: hrcA

Synonym: L0212

Alternate gene names: 15672934

Gene position: 976778-977821 (Clockwise)

Preceding gene: 15672933

Following gene: 15672935

Centisome position: 41.29

GC content: 34.67

Gene sequence:

>1044_bases
ATGATTACAGAACGTCAAAGACAAATTTTAAATTTGATTGTTTCTCTTTATGCCAAAGAGCATACGCCAATTGGTTCAAA
GTCGCTCCTTGATAGTATTCAAGCTTCTAGTGCTACAATCCGAAACGACATGAAAGTCTTGGAAAAACTAGGTTTGATTC
AAAAAGAACACACCTCAAGTGGACGTGTTCCAAGTGTTTCAGGTTATAAGTATTTTGTAGAAAATGTCATCCAGTTAGAT
GAATTTAGTCAAAATGACTTATTTAAAGTGATGAAAGCTTTTGATGGTGATTTTTATCGCTTATCTGACCTGTTTAAAAC
AGCGGCTAAAAGTTTATCAGGACTCACTGGTTTGACAAGCTTTGTACTTAATGCTCCCCAACGTGACCAACAATTAGTTT
CATTTGAAATGGTCATGCTGGATAGTCATTCAGTACTTTCAGTTATAACATTAGGGACTGGTGAAGTAAGAACAAATCAA
TTTATTCTTCCAAAATCGATGACCGAAGCTGATTTAGCAGTCTTTAGTAATCTAGTTAAAGAACGTCTGGTTGGTAAAAA
AGTGATTGATATTCACTATACTTTACGAACAGAGATTCCACAGATTGTTCAGCGTTATTTCAAAGTTACGAGTGAAGTTC
TCCAACTCTTTGAATCAATTTTTGATGATTTGTTCAAAGAACGGCTGACCGTCGCTGGGCGTAAAAATATCTTTGATTAT
GCAACTGACAATCTTGCAGAATTATATAAACTCTTTAGCGATGATGAACGGATGCTTCATGAAATTCGCGAAATCACTAA
TAACGATGAAATGCGGGCCGTTAAATTTGACAATGACGAAAAATATATGAAAAATTTAACGATTATTTCGCAAAAATTTG
TTATCCCATATCGCGGTTTTGGTACACTAACAGTCGTTGGACCTGTAGAAATGGATTATCAAAGGACGTTATCAGTTCTT
GACTTAGTTGCTAAAGTTTTAACTATGAAGCTGAGTGACTATTATCGTTATCTTGATGGTAACCATTATGAAATTAGTAA
ATGA

Upstream 100 bases:

>100_bases
AAAGCTTGTAGATACTAAACAGAAGTCAAAGGCTCAAGAAATTTTTGAGCTTGCGAAAGAAGTTTTGCCGAACTTCTTAT
CTGTGGAGAAAGGAGTAGTC

Downstream 100 bases:

>100_bases
TAAAAAAGTTATTTAAAAAAGGAGGGCCTATGTCCGAAGAAACTAAAGAAGAAATCAAAAATGAAAAAGTTGATGAAGAA
GTGACTGAGGAGTTGACAGA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MITERQRQILNLIVSLYAKEHTPIGSKSLLDSIQASSATIRNDMKVLEKLGLIQKEHTSSGRVPSVSGYKYFVENVIQLD
EFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSGLTGLTSFVLNAPQRDQQLVSFEMVMLDSHSVLSVITLGTGEVRTNQ
FILPKSMTEADLAVFSNLVKERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKERLTVAGRKNIFDY
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKYMKNLTIISQKFVIPYRGFGTLTVVGPVEMDYQRTLSVL
DLVAKVLTMKLSDYYRYLDGNHYEISK

Sequences:

>Translated_347_residues
MITERQRQILNLIVSLYAKEHTPIGSKSLLDSIQASSATIRNDMKVLEKLGLIQKEHTSSGRVPSVSGYKYFVENVIQLD
EFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSGLTGLTSFVLNAPQRDQQLVSFEMVMLDSHSVLSVITLGTGEVRTNQ
FILPKSMTEADLAVFSNLVKERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKERLTVAGRKNIFDY
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKYMKNLTIISQKFVIPYRGFGTLTVVGPVEMDYQRTLSVL
DLVAKVLTMKLSDYYRYLDGNHYEISK
>Mature_347_residues
MITERQRQILNLIVSLYAKEHTPIGSKSLLDSIQASSATIRNDMKVLEKLGLIQKEHTSSGRVPSVSGYKYFVENVIQLD
EFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSGLTGLTSFVLNAPQRDQQLVSFEMVMLDSHSVLSVITLGTGEVRTNQ
FILPKSMTEADLAVFSNLVKERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKERLTVAGRKNIFDY
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKYMKNLTIISQKFVIPYRGFGTLTVVGPVEMDYQRTLSVL
DLVAKVLTMKLSDYYRYLDGNHYEISK

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_LACLA (Q9CGZ0)

Other databases:

- EMBL:   AE005176
- PIR:   H86743
- RefSeq:   NP_267108.1
- GeneID:   1114583
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0212
- NMPDR:   fig|272623.1.peg.975
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   LLAC272623:L0212-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39863; Mature: 39863

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITERQRQILNLIVSLYAKEHTPIGSKSLLDSIQASSATIRNDMKVLEKLGLIQKEHTSS
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GRVPSVSGYKYFVENVIQLDEFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSGLTGLTS
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FVLNAPQRDQQLVSFEMVMLDSHSVLSVITLGTGEVRTNQFILPKSMTEADLAVFSNLVK
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCEECCCCCCHHHHHHHHHHHH
ERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKERLTVAGRKNIFDY
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKYMKNLTIISQKFVIPYRGF
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHEEEEEECCC
GTLTVVGPVEMDYQRTLSVLDLVAKVLTMKLSDYYRYLDGNHYEISK
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MITERQRQILNLIVSLYAKEHTPIGSKSLLDSIQASSATIRNDMKVLEKLGLIQKEHTSS
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GRVPSVSGYKYFVENVIQLDEFSQNDLFKVMKAFDGDFYRLSDLFKTAAKSLSGLTGLTS
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FVLNAPQRDQQLVSFEMVMLDSHSVLSVITLGTGEVRTNQFILPKSMTEADLAVFSNLVK
HHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCEECCCCCCHHHHHHHHHHHH
ERLVGKKVIDIHYTLRTEIPQIVQRYFKVTSEVLQLFESIFDDLFKERLTVAGRKNIFDY
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ATDNLAELYKLFSDDERMLHEIREITNNDEMRAVKFDNDEKYMKNLTIISQKFVIPYRGF
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHEEEEEECCC
GTLTVVGPVEMDYQRTLSVLDLVAKVLTMKLSDYYRYLDGNHYEISK
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471