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The map label for this gene is ispA

Identifier: 15672839

GI number: 15672839

Start: 880761

End: 881618

Strand: Direct

Name: ispA

Synonym: L80459

Alternate gene names: 15672839

Gene position: 880761-881618 (Clockwise)

Preceding gene: 15672838

Following gene: 15672840

Centisome position: 37.23

GC content: 37.41

Gene sequence:

>858_bases
ATGGATACGAAGATACTAAAGTTAGAAGACTTTTTAACTGAATTTTATGAAAGCGCTGAATTTCCAACTGGCTTAGCCGA
ATCAGCAAAATATTCTTTATTGGCAGGCGGTAAACGAATTCGCCCCCTCCTTTTTTTAAACCTATTAGAGGCTTTTGATT
TAGAATTGAGTAAGGCTCATTATCATGTGGCAGCCGCACTTGAGATGATTCATACGGGTTCTTTAATCCATGATGACTTA
CCAGCAATGGATAATGATGATTATCGTCGAGGGCAGTTAACTAATCACAAGAAATTTGACGAGGCAACTGCAATTTTAGC
TGGTGATACTTTATTTTTTGACCCTTTCTTTATCCTTTCAACTGCTGATTTATCCGCAGAAATAATAGTAGCGTTGACGC
GTGAATTGGCCTTTGCTTCAGGTTCTTATGGAATGGTTGCGGGTCAAATCTTGGATATGGCTGGTGAAGGAAAAGAGTTG
ACATTAGCTGAAATTGAGCAGATTCATCGCTTGAAAACTGGGCGACTTTTAACTTTTCCTTTTGTAGCTGCTGGAATTGT
TGCTCAAAAATCAACGGATGAAGTTGAAAAACTTCGTCAAGTGGGGCAAATTTTGGGATTGGCTTTTCAAATTCGAGACG
ATATTTTAGATGTCACAGCAACTTTTGCTGAGCTTGGAAAAACACCAGGTAAGGATATTTTAGAGGAGAAATCAACATAT
GTTGCTCATTTAGGACTTGAGGGAGCAAAAAAATCACTGACAGGAAATTTGTCAGAAGTTAAAAAATTACTGACAGACTT
ATCAGTTACTGACAGCTCTGAAATTTTTAAAATTATTGAGCAATTGGAAGTGAAATAA

Upstream 100 bases:

>100_bases
GCAAAAGGCTCACTTATAAAAATGGAATGGATTTAAAAAATAAAAAAATTTCCACAAATCATCACGGTTTTTAGCCGTGA
ATTTTGGTATAATTAGGGTA

Downstream 100 bases:

>100_bases
AAAAAATAGAAATATAAAAAGAAATTATTAGTTACATTTCTAAGAAAAATACGTATAATTACTATAAAGAAAGATCTACA
TGAAAGAAAGAATTGACGTA

Product: farnesyl diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MDTKILKLEDFLTEFYESAEFPTGLAESAKYSLLAGGKRIRPLLFLNLLEAFDLELSKAHYHVAAALEMIHTGSLIHDDL
PAMDNDDYRRGQLTNHKKFDEATAILAGDTLFFDPFFILSTADLSAEIIVALTRELAFASGSYGMVAGQILDMAGEGKEL
TLAEIEQIHRLKTGRLLTFPFVAAGIVAQKSTDEVEKLRQVGQILGLAFQIRDDILDVTATFAELGKTPGKDILEEKSTY
VAHLGLEGAKKSLTGNLSEVKKLLTDLSVTDSSEIFKIIEQLEVK

Sequences:

>Translated_285_residues
MDTKILKLEDFLTEFYESAEFPTGLAESAKYSLLAGGKRIRPLLFLNLLEAFDLELSKAHYHVAAALEMIHTGSLIHDDL
PAMDNDDYRRGQLTNHKKFDEATAILAGDTLFFDPFFILSTADLSAEIIVALTRELAFASGSYGMVAGQILDMAGEGKEL
TLAEIEQIHRLKTGRLLTFPFVAAGIVAQKSTDEVEKLRQVGQILGLAFQIRDDILDVTATFAELGKTPGKDILEEKSTY
VAHLGLEGAKKSLTGNLSEVKKLLTDLSVTDSSEIFKIIEQLEVK
>Mature_285_residues
MDTKILKLEDFLTEFYESAEFPTGLAESAKYSLLAGGKRIRPLLFLNLLEAFDLELSKAHYHVAAALEMIHTGSLIHDDL
PAMDNDDYRRGQLTNHKKFDEATAILAGDTLFFDPFFILSTADLSAEIIVALTRELAFASGSYGMVAGQILDMAGEGKEL
TLAEIEQIHRLKTGRLLTFPFVAAGIVAQKSTDEVEKLRQVGQILGLAFQIRDDILDVTATFAELGKTPGKDILEEKSTY
VAHLGLEGAKKSLTGNLSEVKKLLTDLSVTDSSEIFKIIEQLEVK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=217, Percent_Identity=29.0322580645161, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786623, Length=262, Percent_Identity=43.5114503816794, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1789578, Length=211, Percent_Identity=32.7014218009479, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17505681, Length=245, Percent_Identity=27.7551020408163, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651612, Length=255, Percent_Identity=29.8039215686275, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31354; Mature: 31354

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKILKLEDFLTEFYESAEFPTGLAESAKYSLLAGGKRIRPLLFLNLLEAFDLELSKAH
CCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
YHVAAALEMIHTGSLIHDDLPAMDNDDYRRGQLTNHKKFDEATAILAGDTLFFDPFFILS
HHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCHHCCCHHEEE
TADLSAEIIVALTRELAFASGSYGMVAGQILDMAGEGKELTLAEIEQIHRLKTGRLLTFP
ECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEHH
FVAAGIVAQKSTDEVEKLRQVGQILGLAFQIRDDILDVTATFAELGKTPGKDILEEKSTY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VAHLGLEGAKKSLTGNLSEVKKLLTDLSVTDSSEIFKIIEQLEVK
EEECCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDTKILKLEDFLTEFYESAEFPTGLAESAKYSLLAGGKRIRPLLFLNLLEAFDLELSKAH
CCCCCHHHHHHHHHHHHHCCCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
YHVAAALEMIHTGSLIHDDLPAMDNDDYRRGQLTNHKKFDEATAILAGDTLFFDPFFILS
HHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCHHCCCHHEEE
TADLSAEIIVALTRELAFASGSYGMVAGQILDMAGEGKELTLAEIEQIHRLKTGRLLTFP
ECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEHH
FVAAGIVAQKSTDEVEKLRQVGQILGLAFQIRDDILDVTATFAELGKTPGKDILEEKSTY
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VAHLGLEGAKKSLTGNLSEVKKLLTDLSVTDSSEIFKIIEQLEVK
EEECCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]