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The map label for this gene is dnaC

Identifier: 15672728

GI number: 15672728

Start: 753514

End: 754881

Strand: Direct

Name: dnaC

Synonym: L0286

Alternate gene names: 15672728

Gene position: 753514-754881 (Clockwise)

Preceding gene: 15672727

Following gene: 15672729

Centisome position: 31.85

GC content: 39.04

Gene sequence:

>1368_bases
ATGCCCGAAATTGATTTAATAAAAGCCCCGCCTCAAGACCTAGCTGCTGAGCAGGCCGTTCTTGGGGCTGTTTTTTTAGA
TAGCGAACGCTTAGTCGAAATTAAAGAATTTTTAAGTTCAGATGATTTCTATAAAAATGCTCACAAGATAATTTTTCGGA
CAATGGAAAAATTATCTGATGCTCGTGAAGCAATTGACGTCTTAACCATTCGTTCACATCTTGAAAATCAAGGGGAGCTG
GAGGCAATTGGTGGGATTGCTTATATTGCAGAACTTGCTACCGCAACCCCCACCGCAGCAAATGCGGCCTATTATGCTAA
GATTGTTGCTGAAAAATCATTACTCCGTCAACTGATAAATCGTCTAACTGAATCAGTCGAAAAAGCTTATGAACAAGATT
CACCAGCGGACGATATTTTAGCTCAAGCAGAAAAAAGTTTAATTGACGTCCAACAAGGACGTAATACAAATGGCTTTAAG
AAAATTTCTGATGTCCTAGCGATTCATATGGATGACCTTGAGCAAAAAGCTCAACAAAAGTCTAATATTACAGGTATCGC
AACAGGTTATCCCGCTTTAGATAACATGACAACAGGTCTTCATGAAGAAGAATTGATTATTCTTGCGGCTCGTCCAGCGG
TTGGTAAAACAGCTTTTGCCTTAAATATTGCTCAAAATATTGGGACAAAGCAAGACCGGACCGTTGCAATTTTCTCTCTT
GAAATGGGGGCAGAAAGTCTTGTCAGCCGGATGATTGCTGCCGAAGGTTCAATTGATTCACACAGCTTACGTACTGGACA
ATTAAATGACCAAGAATGGAATGATTATTTCATGGCAACAGGGACTTTATCAAGAGCAAGTATTTATATTGATGACACAC
CAGGGATAAAGATTTCTGAAATTCGGGCGCGTTCAAGAAAATTAGCCCAAGAAACAGGAAATCTTGGTTTGATTGTTATT
GACTACTTACAATTGATTTCTGGAACTGGTCGAGAAAATCGTCAACAAGAAGTTTCTGAAATTTCTCGTCAGTTAAAAAT
TTTAGCTAAAGAATTAAAAGTTCCTGTTATTGCCCTTTCACAGCTCTCACGTGGAGTGGAACAACGTCAAGATAAACGAC
CAGTTTTGTCTGATATCCGTGAATCTGGGTCAATCGAGCAAGATGCCGATATTGTCGCATTTCTTTATCGAGATGACTAT
TATGAACGTGGAACCGGTGAAGATGAAGACGGTGAAGAGATTCTGGAAGATAATAAAGTTGAAGTTATTATTGAAAAAAA
CCGTTCAGGAAGCCGTGGAACAGTCGAATTACTCTTTATTAAAGAGCATAATAAATTCGCAAGTATTGATAACCGATATG
GCGACTAG

Upstream 100 bases:

>100_bases
TTAACAAAATTCAAGCTTTGGGAACAAAAGATGTACCAGTTAAACTTCACCGTGATGTGACAGCCGTGGTTAAAGTCAAA
ATTAGCGAGGCCTAAACTAA

Downstream 100 bases:

>100_bases
ATTTTTTTGACTAATTCGTGTTATAATATGAGTAATTGTCTAATTCTCTTTATTAATAAAAATGAACGATAAAGAATACA
TTATAAAATTTGATTCTTTT

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPEIDLIKAPPQDLAAEQAVLGAVFLDSERLVEIKEFLSSDDFYKNAHKIIFRTMEKLSDAREAIDVLTIRSHLENQGEL
EAIGGIAYIAELATATPTAANAAYYAKIVAEKSLLRQLINRLTESVEKAYEQDSPADDILAQAEKSLIDVQQGRNTNGFK
KISDVLAIHMDDLEQKAQQKSNITGIATGYPALDNMTTGLHEEELIILAARPAVGKTAFALNIAQNIGTKQDRTVAIFSL
EMGAESLVSRMIAAEGSIDSHSLRTGQLNDQEWNDYFMATGTLSRASIYIDDTPGIKISEIRARSRKLAQETGNLGLIVI
DYLQLISGTGRENRQQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDY
YERGTGEDEDGEEILEDNKVEVIIEKNRSGSRGTVELLFIKEHNKFASIDNRYGD

Sequences:

>Translated_455_residues
MPEIDLIKAPPQDLAAEQAVLGAVFLDSERLVEIKEFLSSDDFYKNAHKIIFRTMEKLSDAREAIDVLTIRSHLENQGEL
EAIGGIAYIAELATATPTAANAAYYAKIVAEKSLLRQLINRLTESVEKAYEQDSPADDILAQAEKSLIDVQQGRNTNGFK
KISDVLAIHMDDLEQKAQQKSNITGIATGYPALDNMTTGLHEEELIILAARPAVGKTAFALNIAQNIGTKQDRTVAIFSL
EMGAESLVSRMIAAEGSIDSHSLRTGQLNDQEWNDYFMATGTLSRASIYIDDTPGIKISEIRARSRKLAQETGNLGLIVI
DYLQLISGTGRENRQQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDY
YERGTGEDEDGEEILEDNKVEVIIEKNRSGSRGTVELLFIKEHNKFASIDNRYGD
>Mature_454_residues
PEIDLIKAPPQDLAAEQAVLGAVFLDSERLVEIKEFLSSDDFYKNAHKIIFRTMEKLSDAREAIDVLTIRSHLENQGELE
AIGGIAYIAELATATPTAANAAYYAKIVAEKSLLRQLINRLTESVEKAYEQDSPADDILAQAEKSLIDVQQGRNTNGFKK
ISDVLAIHMDDLEQKAQQKSNITGIATGYPALDNMTTGLHEEELIILAARPAVGKTAFALNIAQNIGTKQDRTVAIFSLE
MGAESLVSRMIAAEGSIDSHSLRTGQLNDQEWNDYFMATGTLSRASIYIDDTPGIKISEIRARSRKLAQETGNLGLIVID
YLQLISGTGRENRQQEVSEISRQLKILAKELKVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYY
ERGTGEDEDGEEILEDNKVEVIIEKNRSGSRGTVELLFIKEHNKFASIDNRYGD

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=459, Percent_Identity=44.2265795206972, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 50475; Mature: 50344

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIDLIKAPPQDLAAEQAVLGAVFLDSERLVEIKEFLSSDDFYKNAHKIIFRTMEKLSD
CCCCCCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AREAIDVLTIRSHLENQGELEAIGGIAYIAELATATPTAANAAYYAKIVAEKSLLRQLIN
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RLTESVEKAYEQDSPADDILAQAEKSLIDVQQGRNTNGFKKISDVLAIHMDDLEQKAQQK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SNITGIATGYPALDNMTTGLHEEELIILAARPAVGKTAFALNIAQNIGTKQDRTVAIFSL
CCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHEEHHHHCCCCCCCEEEEEEE
EMGAESLVSRMIAAEGSIDSHSLRTGQLNDQEWNDYFMATGTLSRASIYIDDTPGIKISE
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCHHH
IRARSRKLAQETGNLGLIVIDYLQLISGTGRENRQQEVSEISRQLKILAKELKVPVIALS
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
QLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYYERGTGEDEDGEEILEDNKV
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCE
EVIIEKNRSGSRGTVELLFIKEHNKFASIDNRYGD
EEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
PEIDLIKAPPQDLAAEQAVLGAVFLDSERLVEIKEFLSSDDFYKNAHKIIFRTMEKLSD
CCCCCCCCCCHHHHHHHHHHHHHEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AREAIDVLTIRSHLENQGELEAIGGIAYIAELATATPTAANAAYYAKIVAEKSLLRQLIN
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
RLTESVEKAYEQDSPADDILAQAEKSLIDVQQGRNTNGFKKISDVLAIHMDDLEQKAQQK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SNITGIATGYPALDNMTTGLHEEELIILAARPAVGKTAFALNIAQNIGTKQDRTVAIFSL
CCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHEEHHHHCCCCCCCEEEEEEE
EMGAESLVSRMIAAEGSIDSHSLRTGQLNDQEWNDYFMATGTLSRASIYIDDTPGIKISE
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCHHH
IRARSRKLAQETGNLGLIVIDYLQLISGTGRENRQQEVSEISRQLKILAKELKVPVIALS
HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
QLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYYERGTGEDEDGEEILEDNKV
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCE
EVIIEKNRSGSRGTVELLFIKEHNKFASIDNRYGD
EEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]