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The map label for this gene is spxA

Identifier: 15672657

GI number: 15672657

Start: 673860

End: 674258

Strand: Direct

Name: spxA

Synonym: L73853

Alternate gene names: 15672657

Gene position: 673860-674258 (Clockwise)

Preceding gene: 15672656

Following gene: 15672660

Centisome position: 28.49

GC content: 35.34

Gene sequence:

>399_bases
ATGATCACAATCTATACAGCACCCTCTTGTACGAGCTGTAAAAAAGCTAAAACTTGGCTTTCATATCACCACATCCCATT
TAACGAAAGAAATCTCATCGCGGATCCTTTATCAACAACAGAGATTAGTCAAATTCTACAAAAATGTGACGATGGTGTTG
AAGGATTAATTTCAAGTAGAAATCGCTTTGTGAAGACTTTGGGTGTTGATTTTGAAGATATTTCACTTTCACAAGCAATT
AAAATTATTTCTGAAAATCCACAAATCATGCGTCGTCCAATTATTATGGATGAAAAACGTCTTCATGTTGGATATAATGA
AGAAGAAATTCGCGCTTTTTTACCTCGTACAGTTCGTGTTTTAGAAAATGGTGGCGCTCGTTTGCGTTCAGCAATTTAA

Upstream 100 bases:

>100_bases
TTTTGAAAAGGTCTTTTTTTAAGTCTATAAATATGGTATAATTGTACAATCATTGATGTTTAATACTATTAGATAAATAA
ATATACACGAAGGAGAGACG

Downstream 100 bases:

>100_bases
TTCATAATTAAAATATTCATTTATTGGAATTTTTATAGACGCATTTGCGTCTTTTTTTGTTGAAAAAAAACCACTGCCAG
AAAGGAACAATGGTTTTTTG

Product: transcriptional regulator Spx

Products: NA

Alternate protein names: Thermoresistant insertional mutant protein A

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSRNRFVKTLGVDFEDISLSQAI
KIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRVLENGGARLRSAI

Sequences:

>Translated_132_residues
MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSRNRFVKTLGVDFEDISLSQAI
KIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRVLENGGARLRSAI
>Mature_132_residues
MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSRNRFVKTLGVDFEDISLSQAI
KIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRVLENGGARLRSAI

Specific function: Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes invo

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family. Spx subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPX2_LACLA (P60375)

Other databases:

- EMBL:   AE005176
- PIR:   C86709
- RefSeq:   NP_266831.1
- ProteinModelPortal:   P60375
- SMR:   P60375
- GeneID:   1114299
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L73853
- NMPDR:   fig|272623.1.peg.693
- HOGENOM:   HBG734370
- OMA:   HERNMNA
- ProtClustDB:   PRK01655
- BioCyc:   LLAC272623:L73853-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- HAMAP:   MF_01132
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335
- InterPro:   IPR006504
- Gene3D:   G3DSA:3.40.30.10
- TIGRFAMs:   TIGR01617

Pfam domain/function: PF03960 ArsC; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 15031; Mature: 15031

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS51353 ARSC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSR
CEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
NRFVKTLGVDFEDISLSQAIKIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRV
HHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHH
LENGGARLRSAI
HHCCCCHHHCCC
>Mature Secondary Structure
MITIYTAPSCTSCKKAKTWLSYHHIPFNERNLIADPLSTTEISQILQKCDDGVEGLISSR
CEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
NRFVKTLGVDFEDISLSQAIKIISENPQIMRRPIIMDEKRLHVGYNEEEIRAFLPRTVRV
HHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHH
LENGGARLRSAI
HHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471; 10048028