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The map label for this gene is ctrA

Identifier: 15672093

GI number: 15672093

Start: 112785

End: 114194

Strand: Direct

Name: ctrA

Synonym: L112776

Alternate gene names: 15672093

Gene position: 112785-114194 (Clockwise)

Preceding gene: 15672092

Following gene: 15672094

Centisome position: 4.77

GC content: 41.21

Gene sequence:

>1410_bases
ATGGGATTTATGAGAAAAGCTGATTTTGAGCTTTATCGAGATGCAGATAAACACTATAATCAGGTGTTAACCACACGTGA
TTTTCTTGCACTAGGTGTTGGAACAATTATTTCGACTTCTATTTTTACTTTACCAGGTCAGGTCGCTGCTCAATTTGCAG
GCCCAGGTGTTGTCTTTTCTTACCTGCTTGCTGCATTGGTCGCTGGTTTTGTTGCCTTGGCTTATGCTGAAATGTCAACA
GTGATGCCATTTGCGGGTTCAGCCTATTCTTGGATTTCAGTCTTATTTGGCGAAGGTTTTGGTTGGATTGCTGGTTGGGC
TTTGCTTGCGGAATATTTTATTGCCGTTGCCTTTGTTGGTTCAGGCTTCTCAGCAAATCTGCAACAATTGCTAGCGCCAC
TCGGTTTCCATCTACCAAAAGTATTGGCCAATCCATTTGGTACAGACGGTGGAGTTGTCGATATTATTTCACTTTTAGTC
ATTTTACTCTCGGCAATTATTGTCTTTCGTGGGGCATCTGATGCTGGACGAATCAGTCAAATTCTTGTTGTGCTTAAAGT
AGCGGCTGTCATTGCTTTCATCATTGTTGGGATTACGGTCATTAAGCCAGCAAATTACCATCCATTTATTCCACCACACA
ATCCCAAAACAGGTTTTGGTGGCTTCTCGGGAATCTGGTCTGGGGTATCAATGATTTTCTTGGCCTATATCGGTTTTGAT
TCAATTGCAGCCAATTCAGCGGAAGCTAAAAAACCCCAAAAAACAATGCCACGTGGAATTATTGGGTCGCTTCTAATTGC
TGTTGTTCTATTTGCAGCAGTAACCTTGGTACTTGTAGGGATGCATCCTTACTCAGCCTATGCAGGAAATGCAGCGCCAG
TTGGTTGGGCTCTTCAACAATCAGGTTATTCTGTTTTATCAGAAGTTGTAACAGCTATTGCACTTGCCGGAATGTTTATC
GCCCTTTTGGGAATGGTTCTTGCAGGTTCACGTTTGCTTTATGCTTTTGGACGCGATGGACTTTTACCTAAAGGTTTGGG
TAAAATGAATGCTCGAAATCTTCCAGCAAATGGTGTGTGGACCTTAGCCATTGTTGCTATTGTCATCGGGGCATTCTTCC
CCTTTGCTTTCCTTGCTCAACTTATTTCAGCAGGAACTTTGATTGCTTTCATGTTTGTTACACTTGGAATCTATTCACTT
CGTCGTCGTCAAGGAAAAGATTTGCCAGAAGCAACTTACAAAATGCCTTTCTATCCAGTTTTACCAGCTCTTGGTTTTAT
TGGTTCATTATTTGTATTTTGGGGATTGGATGTGCAAGCAAAACTTTATTCAGGAATTTGGTTCCTTATTGGAATTTTGA
TTTATTTTGCTTATGGAAATCGTCGAAGCAGAAAATCAGAAGAAAAATAA

Upstream 100 bases:

>100_bases
ATACTGCATAAAGTTAGTTCTTGACAATTGTCAGACAATTCGGTAAAATACAGTTTATTGAAATTATTTAGTTACAAATT
CAGAAAAATGAGGATTTATT

Downstream 100 bases:

>100_bases
AAAGATATTATAAAAAATGGTTTCAAAATCTTTTGGAACCATTTTTTTGTCATCATTTTGGAGCGGACAAAAATTGCTAA
AATTACTAAAATAAGTTAAA

Product: cationic amino acid transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MGFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFSYLLAALVAGFVALAYAEMST
VMPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVGSGFSANLQQLLAPLGFHLPKVLANPFGTDGGVVDIISLLV
ILLSAIIVFRGASDAGRISQILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFD
SIAANSAEAKKPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQSGYSVLSEVVTAIALAGMFI
ALLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVWTLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSL
RRRQGKDLPEATYKMPFYPVLPALGFIGSLFVFWGLDVQAKLYSGIWFLIGILIYFAYGNRRSRKSEEK

Sequences:

>Translated_469_residues
MGFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFSYLLAALVAGFVALAYAEMST
VMPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVGSGFSANLQQLLAPLGFHLPKVLANPFGTDGGVVDIISLLV
ILLSAIIVFRGASDAGRISQILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFD
SIAANSAEAKKPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQSGYSVLSEVVTAIALAGMFI
ALLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVWTLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSL
RRRQGKDLPEATYKMPFYPVLPALGFIGSLFVFWGLDVQAKLYSGIWFLIGILIYFAYGNRRSRKSEEK
>Mature_468_residues
GFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFSYLLAALVAGFVALAYAEMSTV
MPFAGSAYSWISVLFGEGFGWIAGWALLAEYFIAVAFVGSGFSANLQQLLAPLGFHLPKVLANPFGTDGGVVDIISLLVI
LLSAIIVFRGASDAGRISQILVVLKVAAVIAFIIVGITVIKPANYHPFIPPHNPKTGFGGFSGIWSGVSMIFLAYIGFDS
IAANSAEAKKPQKTMPRGIIGSLLIAVVLFAAVTLVLVGMHPYSAYAGNAAPVGWALQQSGYSVLSEVVTAIALAGMFIA
LLGMVLAGSRLLYAFGRDGLLPKGLGKMNARNLPANGVWTLAIVAIVIGAFFPFAFLAQLISAGTLIAFMFVTLGIYSLR
RRQGKDLPEATYKMPFYPVLPALGFIGSLFVFWGLDVQAKLYSGIWFLIGILIYFAYGNRRSRKSEEK

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of D-Alanine, D-Serine And Glycine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=435, Percent_Identity=30.8045977011494, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI258645169, Length=432, Percent_Identity=28.0092592592593, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI258614005, Length=433, Percent_Identity=28.175519630485, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI258614003, Length=434, Percent_Identity=28.110599078341, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI181337167, Length=407, Percent_Identity=29.97542997543, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI114326544, Length=426, Percent_Identity=29.3427230046948, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI114326550, Length=426, Percent_Identity=29.3427230046948, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI110347453, Length=394, Percent_Identity=29.4416243654822, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790653, Length=486, Percent_Identity=23.6625514403292, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788480, Length=490, Percent_Identity=25.3061224489796, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081708, Length=484, Percent_Identity=22.3140495867769, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786302, Length=420, Percent_Identity=22.1428571428571, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082250, Length=457, Percent_Identity=26.6958424507659, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786602, Length=474, Percent_Identity=23.4177215189873, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI2367353, Length=369, Percent_Identity=24.390243902439, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081915, Length=425, Percent_Identity=22.1176470588235, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786908, Length=319, Percent_Identity=22.884012539185, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081869, Length=424, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786789, Length=419, Percent_Identity=22.1957040572792, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994972, Length=479, Percent_Identity=22.5469728601253, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082023, Length=432, Percent_Identity=24.7685185185185, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789017, Length=426, Percent_Identity=23.0046948356808, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786694, Length=404, Percent_Identity=25, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17532491, Length=454, Percent_Identity=29.0748898678414, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531343, Length=416, Percent_Identity=28.125, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17533459, Length=405, Percent_Identity=28.641975308642, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321053, Length=323, Percent_Identity=23.2198142414861, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=451, Percent_Identity=23.2815964523282, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321629, Length=448, Percent_Identity=21.875, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=31.6666666666667, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=31.6666666666667, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24668806, Length=426, Percent_Identity=29.5774647887324, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356285, Length=426, Percent_Identity=29.5774647887324, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24668802, Length=426, Percent_Identity=29.5774647887324, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24667468, Length=412, Percent_Identity=29.126213592233, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI161077963, Length=413, Percent_Identity=28.3292978208232, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI281366235, Length=406, Percent_Identity=30.2955665024631, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI116007820, Length=406, Percent_Identity=30.2955665024631, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI116007818, Length=403, Percent_Identity=30.5210918114144, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI85725152, Length=403, Percent_Identity=30.5210918114144, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50093; Mature: 49962

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GFMRKADFELYRDADKHYNQVLTTRDFLALGVGTIISTSIFTLPGQVAAQFAGPGVVFS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHH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HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]