Click here to switch to the map view.

The map label for this gene is cadA

Identifier: 15672077

GI number: 15672077

Start: 96595

End: 98376

Strand: Direct

Name: cadA

Synonym: L96595

Alternate gene names: 15672077

Gene position: 96595-98376 (Clockwise)

Preceding gene: 15672073

Following gene: 15672081

Centisome position: 4.08

GC content: 39.45

Gene sequence:

>1782_bases
ATGAAGAACTGGAAAAAACTGATTCTTGTTTTTGTCATTGCAGGCGTGGCATTGATTGCTTACTTTGGCTTTAATCAGCC
TTTTTTGGCACGCTTAATTGTTACAATTGCTGGGGGAGTCTTGGCTTTCTCAATGCTGATTGAAATGATTAAAACTTTAC
GGTCGGGCTCTTATGGTGTTGACTTATTGGCCATCACGGCCATTATTGCTACTTTACTAGTGGGCGAATATTGGGCCTCT
TTGATTATTATTCTCATGCTTGATGGAGGTGAGAGTTTAGAAGACTATGCAAATGGTCGAGCTCACCGAGCTTTAGCTGC
TTTATTAGATAAGTCGCCTGATATTGCTCATGTGCAAAAAGGAGATAAGGTGGTCGATTTACCGATAGAACATGTGGAAG
TCGGGAGTCATTTATTGATTAGACCGATGGAAATTATTCCAATTGACGGGAAACTTATTTCTGAGGCAGTGGTACTTGAT
ACGGCGTCATTGACGGGTGAAACCAAGCCGAATGAATTAGTAAAAGGTGATCCTGTTCTTTCGGGAGCTATCAATGGGAA
TTCTAGTATCCAGATTGAAACTACGGTGATAGCGGCAGAATCACAGTTTCAAAAGATTGTAGAACTGGTTAAAGAAACGG
AGAAAACTCCAGCTCAGTTTGTACGTCTGGCTGATCGTTATGCTGTTCCTTTTACAATTATTGCCTATCTTATTGCAGCA
GTTGCTTACTTTATTGCTGGTGACCCTGTGCGGATTGCGGAAGTCCTAGTGGTTGCAAGCCCTTGTCCATTGATTCTGGC
AGCCCCTATCGCGTTTGTTTCGGGAATGAGTCGCTCTAGTCAAAATGGAGCATTAATCAAAAATGGAACAGTCATCGAAA
AATTAGCAAAAGCTCGGGAAATATTTTTAGATAAAACAGGTACAATTACTGAGGGGACAATTAAGGTTGACAGTCTAAAA
CCAATAGAAACGGTAGATGAAGTAGAACTTTTACAGTTGGTTTACACGGTTGAAAAATCAAGTGGTCATATTTTAGCAAA
AGCTGTTGTTGAATATGCTGAGAATAAAAAGGTTCAACCATTAAAATTGACCTCTTTAACTGAGGTTGCTGGACTTGGTG
TGATTGGAGAAATCGAAGGTCAAGAAATTAAAATTGGGCGAAGTTCTTTTGCTTTTGCACCTGATAATCTCAACTATGAA
ACAGCATTTTATGTGAGTAAAGCAGGTAAATATGTTGGGGCGGTCACATTCTCTGATACTTTAAGACCAGAAGCTAAAGA
AACAATTGCTCAGATGAGAAAAATTGGTCTTGAAAAGATTACAATGTTGACGGGTGACAATCAACTTGTTGCTGATAAAA
TTGCGAGCACTGTTGGAATTGACAATGTTTATGCAGGTTTGATGCCAGATGAAAAATTAAAATTTATTAAAAATGCGACG
AATAGACCAGTAATTATGATTGGAGATGGAGTTAATGATGCTCCAGCTCTAGCCACAGCAGATGTTGGAATTTCGATTGG
TGTGGGCTCAGGTACAGTTGCAAGTGAAGCGGCTGACATTGTTCTATTGCAAAATGACCTTAGGAAAGTGACGACATCTA
TTGAAATCAGTCGTGATACGTTAAAAATTGCTAAACAAGCGGTCATGATTGGGATTATCATTTGTATTATTTTGATGTTT
GTTGCAGCTCTGGGAGTGATTCCAGCTGTGATTGGAGCTTTGTTCCAAGAGATCATTGATGTTGTTTCAATTCTCTATGC
GCTTCGAGCTTTAAGAGGATAA

Upstream 100 bases:

>100_bases
AAAGAATCAAAGCGGCGTAAGGAGAAGACAATCAGGTCGTAAAAACTCCTCACAAAGCAGGGCAATGTTCTAGGACAATT
AAATTTTTAAGGAGAAATGA

Downstream 100 bases:

>100_bases
AGAAAAAATTTACTGACGGAATGCTTAAAAGTACTCTGTCAGTAAATTTTTTTTATTTTTTTAGTAATTTTATTAGATGT
TCTAGTTCATCAAGATTATC

Product: cadmium efflux ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLIVTIAGGVLAFSMLIEMIKTLRSGSYGVDLLAITAIIATLLVGEYWAS
LIIILMLDGGESLEDYANGRAHRALAALLDKSPDIAHVQKGDKVVDLPIEHVEVGSHLLIRPMEIIPIDGKLISEAVVLD
TASLTGETKPNELVKGDPVLSGAINGNSSIQIETTVIAAESQFQKIVELVKETEKTPAQFVRLADRYAVPFTIIAYLIAA
VAYFIAGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAREIFLDKTGTITEGTIKVDSLK
PIETVDEVELLQLVYTVEKSSGHILAKAVVEYAENKKVQPLKLTSLTEVAGLGVIGEIEGQEIKIGRSSFAFAPDNLNYE
TAFYVSKAGKYVGAVTFSDTLRPEAKETIAQMRKIGLEKITMLTGDNQLVADKIASTVGIDNVYAGLMPDEKLKFIKNAT
NRPVIMIGDGVNDAPALATADVGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDTLKIAKQAVMIGIIICIILMF
VAALGVIPAVIGALFQEIIDVVSILYALRALRG

Sequences:

>Translated_593_residues
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLIVTIAGGVLAFSMLIEMIKTLRSGSYGVDLLAITAIIATLLVGEYWAS
LIIILMLDGGESLEDYANGRAHRALAALLDKSPDIAHVQKGDKVVDLPIEHVEVGSHLLIRPMEIIPIDGKLISEAVVLD
TASLTGETKPNELVKGDPVLSGAINGNSSIQIETTVIAAESQFQKIVELVKETEKTPAQFVRLADRYAVPFTIIAYLIAA
VAYFIAGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAREIFLDKTGTITEGTIKVDSLK
PIETVDEVELLQLVYTVEKSSGHILAKAVVEYAENKKVQPLKLTSLTEVAGLGVIGEIEGQEIKIGRSSFAFAPDNLNYE
TAFYVSKAGKYVGAVTFSDTLRPEAKETIAQMRKIGLEKITMLTGDNQLVADKIASTVGIDNVYAGLMPDEKLKFIKNAT
NRPVIMIGDGVNDAPALATADVGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDTLKIAKQAVMIGIIICIILMF
VAALGVIPAVIGALFQEIIDVVSILYALRALRG
>Mature_593_residues
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLIVTIAGGVLAFSMLIEMIKTLRSGSYGVDLLAITAIIATLLVGEYWAS
LIIILMLDGGESLEDYANGRAHRALAALLDKSPDIAHVQKGDKVVDLPIEHVEVGSHLLIRPMEIIPIDGKLISEAVVLD
TASLTGETKPNELVKGDPVLSGAINGNSSIQIETTVIAAESQFQKIVELVKETEKTPAQFVRLADRYAVPFTIIAYLIAA
VAYFIAGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKAREIFLDKTGTITEGTIKVDSLK
PIETVDEVELLQLVYTVEKSSGHILAKAVVEYAENKKVQPLKLTSLTEVAGLGVIGEIEGQEIKIGRSSFAFAPDNLNYE
TAFYVSKAGKYVGAVTFSDTLRPEAKETIAQMRKIGLEKITMLTGDNQLVADKIASTVGIDNVYAGLMPDEKLKFIKNAT
NRPVIMIGDGVNDAPALATADVGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDTLKIAKQAVMIGIIICIILMF
VAALGVIPAVIGALFQEIIDVVSILYALRALRG

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=712, Percent_Identity=27.247191011236, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI55743073, Length=511, Percent_Identity=29.3542074363992, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI115529486, Length=601, Percent_Identity=24.7920133111481, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI28373105, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373107, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373115, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373111, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373103, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373113, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI28373109, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI10835220, Length=214, Percent_Identity=29.4392523364486, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI27886529, Length=214, Percent_Identity=29.4392523364486, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786691, Length=530, Percent_Identity=32.6415094339623, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1789879, Length=599, Percent_Identity=30.0500834724541, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI1786914, Length=524, Percent_Identity=28.6259541984733, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI2367363, Length=551, Percent_Identity=22.5045372050817, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556548, Length=154, Percent_Identity=40.9090909090909, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17557486, Length=136, Percent_Identity=36.0294117647059, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=30, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319772, Length=626, Percent_Identity=26.038338658147, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6321271, Length=156, Percent_Identity=32.6923076923077, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321432, Length=189, Percent_Identity=30.6878306878307, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329854, Length=396, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24668704, Length=154, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24668708, Length=154, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281366617, Length=154, Percent_Identity=31.1688311688312, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24668696, Length=154, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI161085803, Length=154, Percent_Identity=31.8181818181818, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 63361; Mature: 63361

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLIVTIAGGVLAFSMLIEMIKTLRSGSYGV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLLAITAIIATLLVGEYWASLIIILMLDGGESLEDYANGRAHRALAALLDKSPDIAHVQK
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHCCHHHHHHHHHHCCCCCEEECCC
GDKVVDLPIEHVEVGSHLLIRPMEIIPIDGKLISEAVVLDTASLTGETKPNELVKGDPVL
CCEEEECCHHHHHCCCCEEECCEEEEECCCHHHHHHHHEECHHCCCCCCCCCCCCCCCCE
SGAINGNSSIQIETTVIAAESQFQKIVELVKETEKTPAQFVRLADRYAVPFTIIAYLIAA
EEEECCCCEEEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
VAYFIAGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKARE
HHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHH
IFLDKTGTITEGTIKVDSLKPIETVDEVELLQLVYTVEKSSGHILAKAVVEYAENKKVQP
HHHCCCCCEEECEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
LKLTSLTEVAGLGVIGEIEGQEIKIGRSSFAFAPDNLNYETAFYVSKAGKYVGAVTFSDT
EECCHHHHHHCCCEEEECCCCEEEECCCCCEECCCCCCCEEEEEEECCCCEEEEEEECCC
LRPEAKETIAQMRKIGLEKITMLTGDNQLVADKIASTVGIDNVYAGLMPDEKLKFIKNAT
CCCHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHCCC
NRPVIMIGDGVNDAPALATADVGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDT
CCCEEEEECCCCCCCCEEEECCCEEEECCCCCCHHCCCCEEEEHHHHHHHHHHHEECHHH
LKIAKQAVMIGIIICIILMFVAALGVIPAVIGALFQEIIDVVSILYALRALRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNWKKLILVFVIAGVALIAYFGFNQPFLARLIVTIAGGVLAFSMLIEMIKTLRSGSYGV
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DLLAITAIIATLLVGEYWASLIIILMLDGGESLEDYANGRAHRALAALLDKSPDIAHVQK
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHCCHHHHHHHHHHCCCCCEEECCC
GDKVVDLPIEHVEVGSHLLIRPMEIIPIDGKLISEAVVLDTASLTGETKPNELVKGDPVL
CCEEEECCHHHHHCCCCEEECCEEEEECCCHHHHHHHHEECHHCCCCCCCCCCCCCCCCE
SGAINGNSSIQIETTVIAAESQFQKIVELVKETEKTPAQFVRLADRYAVPFTIIAYLIAA
EEEECCCCEEEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
VAYFIAGDPVRIAEVLVVASPCPLILAAPIAFVSGMSRSSQNGALIKNGTVIEKLAKARE
HHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHH
IFLDKTGTITEGTIKVDSLKPIETVDEVELLQLVYTVEKSSGHILAKAVVEYAENKKVQP
HHHCCCCCEEECEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
LKLTSLTEVAGLGVIGEIEGQEIKIGRSSFAFAPDNLNYETAFYVSKAGKYVGAVTFSDT
EECCHHHHHHCCCEEEECCCCEEEECCCCCEECCCCCCCEEEEEEECCCCEEEEEEECCC
LRPEAKETIAQMRKIGLEKITMLTGDNQLVADKIASTVGIDNVYAGLMPDEKLKFIKNAT
CCCHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHCCC
NRPVIMIGDGVNDAPALATADVGISIGVGSGTVASEAADIVLLQNDLRKVTTSIEISRDT
CCCEEEEECCCCCCCCEEEECCCEEEECCCCCCHHCCCCEEEEHHHHHHHHHHHEECHHH
LKIAKQAVMIGIIICIILMFVAALGVIPAVIGALFQEIIDVVSILYALRALRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]