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The map label for this gene is pth

Identifier: 15671994

GI number: 15671994

Start: 16598

End: 17164

Strand: Direct

Name: pth

Synonym: L0365

Alternate gene names: 15671994

Gene position: 16598-17164 (Clockwise)

Preceding gene: 15671993

Following gene: 15671995

Centisome position: 0.7

GC content: 37.21

Gene sequence:

>567_bases
ATGACAAAAATGATTGTTGGCTTGGGAAACCCAGGCGATAAATATGAAAAAACAAAACATAATATGGGCTTTATGGCACT
TGATTTACTGGCAAAAGAACTGAATGTTGATTTTAAAGAAGAAAAACCTTTTATGTCGCTTGTCGCGTCAACGTTTGTGA
ATGGTGAAAAATTGTTTCTCGTGAAACCTCTGACTTTTATGAATGAATCTGGGCGGTCGGTGGCGCCACTTTTGAAATAT
TATAATATAGACGAAGCAGATTTAACGGTCATGCATGATGACTTGGATTCACCAGTCGGGCGCGTGCGTCTAAGACAAAA
AGGGTCATCAGGTGGACAAAATGGAATAAAATCAGTCATTACACATGTGGGAAGTCAAACTTTTAACCGTGTAAAAATTG
GGATTGGCCGTCCAAAACATGGGATGACAGTTGGGAATCATGTACTCTCTGGTTTTGACAATGAAGATAAGGAAATCGCT
CAAGATGGAATTTTCAAAGCTGTTGATGCAATGAAATTCTATCTTGAAAATGGTGATTTTCAAAAGACAATGAATAAATT
TAACTAA

Upstream 100 bases:

>100_bases
AACTGATAAATGCTCAAAAAAATAAAATTGTTTTACACAATAAAAGAGAAATTCGGCAATTTATAAAAAATTTTCAAAAA
TAGAGAAGAAAGAATAGAAA

Downstream 100 bases:

>100_bases
ATGAATATTATTGAATTTTTTGACCAAAATTGGCAACTACAAAAATGGCAACAAGGTTTTTCAAAGCGTGAGCGAACTTT
ACTGACAGGATTGTCAGGAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRSVAPLLKY
YNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVGNHVLSGFDNEDKEIA
QDGIFKAVDAMKFYLENGDFQKTMNKFN

Sequences:

>Translated_188_residues
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRSVAPLLKY
YNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVGNHVLSGFDNEDKEIA
QDGIFKAVDAMKFYLENGDFQKTMNKFN
>Mature_187_residues
TKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFLVKPLTFMNESGRSVAPLLKYY
NIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVITHVGSQTFNRVKIGIGRPKHGMTVGNHVLSGFDNEDKEIAQ
DGIFKAVDAMKFYLENGDFQKTMNKFN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=33.9285714285714, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=34.2245989304813, Blast_Score=107, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321983, Length=138, Percent_Identity=31.1594202898551, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_LACLA (Q9CJI1)

Other databases:

- EMBL:   AE005176
- PIR:   D86626
- RefSeq:   NP_266168.1
- ProteinModelPortal:   Q9CJI1
- SMR:   Q9CJI1
- GeneID:   1113611
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0365
- NMPDR:   fig|272623.1.peg.13
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   LLAC272623:L0365-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20937; Mature: 20806

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFL
CCEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
VKPLTFMNESGRSVAPLLKYYNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVI
ECCHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHH
THVGSQTFNRVKIGIGRPKHGMTVGNHVLSGFDNEDKEIAQDGIFKAVDAMKFYLENGDF
HHHCCHHHCEEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QKTMNKFN
HHHHHHCC
>Mature Secondary Structure 
TKMIVGLGNPGDKYEKTKHNMGFMALDLLAKELNVDFKEEKPFMSLVASTFVNGEKLFL
CEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEE
VKPLTFMNESGRSVAPLLKYYNIDEADLTVMHDDLDSPVGRVRLRQKGSSGGQNGIKSVI
ECCHHHHCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHH
THVGSQTFNRVKIGIGRPKHGMTVGNHVLSGFDNEDKEIAQDGIFKAVDAMKFYLENGDF
HHHCCHHHCEEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QKTMNKFN
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471