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The map label for this gene is dnaA

Identifier: 15671983

GI number: 15671983

Start: 358

End: 1725

Strand: Direct

Name: dnaA

Synonym: L0274

Alternate gene names: 15671983

Gene position: 358-1725 (Clockwise)

Preceding gene: NA

Following gene: 15671984

Centisome position: 0.02

GC content: 37.43

Gene sequence:

>1368_bases
ATGGCATCCCTTAATGAAAATCAAAAATTTTGGGCCCGTGTAACCGAACTAGCTCAGCAGAGTATCGGTAAACAAGCTTA
TGATTTTTTTATTGAGCCTGCTCAATTAATGTCTGTCGAGCAAGATACTGCCAATATCTTGCTTGATAGTGGAATGAAAA
AAGATTATTGGAAAAAACAGTCCGATTTGATCACAACGGCGGGATTTGAGGTCTTTGGTCGGATGATTGATTATGAACTC
TATGCAAATGATGAGTTAACTGAACTGGAACTTCATCGTTTAAATAATCAATCTTCTATTGAAGAGCAGCCGCGTTCTAC
TGCTAAACCCGCTTCTCCTTTGGTTAGTGGTCTCAACGAGAAATATAATTTTGAAAATTTTGTGCAAGGTCCTGGTAACC
GTTGGACTTTGGCTGCGGCAATTGCTGTTGCTGATAAACCTGGTGATACCTATAATCCACTATTTATTTATGGTGGAGCT
GGTCTAGGTAAGACGCATTTAATGCATGCAATTGGAAATCAGATTTTGACTGACAATCCGACTGCTCGAATTAAATATGT
TTCTTCGGAGAATTTCGTTAACGACTATGTTAATGCAACGCGAAAAAACCAAATGGAGAATTTTGAAAATACTTATCGTA
ATTTAGATTTACTTCTATTGGACGATGTGCAATTTTTCAGTGATAAAGAGGGGACGAAAAATGAATTTTTCAATACCTTC
AACGCACTCTATGATAAAGGTTCCCAAATTGTTTTAACTTCTGATCGTATTCCGCAAGAATTAAATAATTTGGAAGATCG
CTTGGTTTCACGCTTCTCTTGGGGTTTGACTACTGATATTACGGCTCCTGACTATGAAACTCGGATGGCTATTCTTTTGA
TTAAATCTGAATCAAGTCGTTTAGAATTTCCGAGTGAAACTCTATCTTATATTGCTGGTCAGATTGATTCAAACGTTCGA
GAACTCGAGGGCGCTCTAAATCGAGTCGAATTTGTGGCTCGAGCAAATGGCATTGCGGTGGTCGATATTGAGACAGCAAG
TCAGGCTTTGCGTTCTTTAAAAAATGCAACTCAGCAATCTTTATCAAATCTTACTATTAAAAAAATTCAAGATGAAGTTG
CTAATTATTATCATATTTCATTTTCAGATCTTGTTGGTCCTAAGCGCCCTAAGGAAATTGCCTTTCCAAGACAGATTGCG
ATGTATCTTGTCAGAGAACTTTTAGGTACAAGTCTTCCGGCAATTGGAACTGCTTTTGGTGGCCGTGACCACACAACGGT
AATGTATGCTTATAAACAAATTTCGGATAAGATGAAAAATGATATGGATGTTCAAAAAGACATCGACAGCATTAAACGTA
AATTTTAA

Upstream 100 bases:

>100_bases
TGGTGGAAAACTTTCTTTTGTTAATTTCAACAGACTGTGGAAAAATATAATGTGAAATGATATAATGAGTTATCAACAAA
CTAAAAAGTAAAGGAGTAAT

Downstream 100 bases:

>100_bases
ACCTGTGGAAAACTCAAGGACTTATAAAATGTTTATTCTTTAATTATCCACAGGGGAAAAGCTTATACTTCTAAGTGGAT
TTGTCTTATACAGATTATCC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MASLNENQKFWARVTELAQQSIGKQAYDFFIEPAQLMSVEQDTANILLDSGMKKDYWKKQSDLITTAGFEVFGRMIDYEL
YANDELTELELHRLNNQSSIEEQPRSTAKPASPLVSGLNEKYNFENFVQGPGNRWTLAAAIAVADKPGDTYNPLFIYGGA
GLGKTHLMHAIGNQILTDNPTARIKYVSSENFVNDYVNATRKNQMENFENTYRNLDLLLLDDVQFFSDKEGTKNEFFNTF
NALYDKGSQIVLTSDRIPQELNNLEDRLVSRFSWGLTTDITAPDYETRMAILLIKSESSRLEFPSETLSYIAGQIDSNVR
ELEGALNRVEFVARANGIAVVDIETASQALRSLKNATQQSLSNLTIKKIQDEVANYYHISFSDLVGPKRPKEIAFPRQIA
MYLVRELLGTSLPAIGTAFGGRDHTTVMYAYKQISDKMKNDMDVQKDIDSIKRKF

Sequences:

>Translated_455_residues
MASLNENQKFWARVTELAQQSIGKQAYDFFIEPAQLMSVEQDTANILLDSGMKKDYWKKQSDLITTAGFEVFGRMIDYEL
YANDELTELELHRLNNQSSIEEQPRSTAKPASPLVSGLNEKYNFENFVQGPGNRWTLAAAIAVADKPGDTYNPLFIYGGA
GLGKTHLMHAIGNQILTDNPTARIKYVSSENFVNDYVNATRKNQMENFENTYRNLDLLLLDDVQFFSDKEGTKNEFFNTF
NALYDKGSQIVLTSDRIPQELNNLEDRLVSRFSWGLTTDITAPDYETRMAILLIKSESSRLEFPSETLSYIAGQIDSNVR
ELEGALNRVEFVARANGIAVVDIETASQALRSLKNATQQSLSNLTIKKIQDEVANYYHISFSDLVGPKRPKEIAFPRQIA
MYLVRELLGTSLPAIGTAFGGRDHTTVMYAYKQISDKMKNDMDVQKDIDSIKRKF
>Mature_454_residues
ASLNENQKFWARVTELAQQSIGKQAYDFFIEPAQLMSVEQDTANILLDSGMKKDYWKKQSDLITTAGFEVFGRMIDYELY
ANDELTELELHRLNNQSSIEEQPRSTAKPASPLVSGLNEKYNFENFVQGPGNRWTLAAAIAVADKPGDTYNPLFIYGGAG
LGKTHLMHAIGNQILTDNPTARIKYVSSENFVNDYVNATRKNQMENFENTYRNLDLLLLDDVQFFSDKEGTKNEFFNTFN
ALYDKGSQIVLTSDRIPQELNNLEDRLVSRFSWGLTTDITAPDYETRMAILLIKSESSRLEFPSETLSYIAGQIDSNVRE
LEGALNRVEFVARANGIAVVDIETASQALRSLKNATQQSLSNLTIKKIQDEVANYYHISFSDLVGPKRPKEIAFPRQIAM
YLVRELLGTSLPAIGTAFGGRDHTTVMYAYKQISDKMKNDMDVQKDIDSIKRKF

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=345, Percent_Identity=49.8550724637681, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_LACLA (Q9CJJ2)

Other databases:

- EMBL:   AE005176
- PIR:   A86625
- RefSeq:   NP_266157.1
- ProteinModelPortal:   Q9CJJ2
- SMR:   Q9CJJ2
- GeneID:   1113599
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0274
- NMPDR:   fig|272623.1.peg.1
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   LLAC272623:L0274-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51462; Mature: 51330

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLNENQKFWARVTELAQQSIGKQAYDFFIEPAQLMSVEQDTANILLDSGMKKDYWKKQ
CCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
SDLITTAGFEVFGRMIDYELYANDELTELELHRLNNQSSIEEQPRSTAKPASPLVSGLNE
HCEEHHHHHHHHHHHHCEEEECCCCCHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCC
KYNFENFVQGPGNRWTLAAAIAVADKPGDTYNPLFIYGGAGLGKTHLMHAIGNQILTDNP
CCCCHHHHCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCEECCCC
TARIKYVSSENFVNDYVNATRKNQMENFENTYRNLDLLLLDDVQFFSDKEGTKNEFFNTF
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCHHHHHHHH
NALYDKGSQIVLTSDRIPQELNNLEDRLVSRFSWGLTTDITAPDYETRMAILLIKSESSR
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCC
LEFPSETLSYIAGQIDSNVRELEGALNRVEFVARANGIAVVDIETASQALRSLKNATQQS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHH
LSNLTIKKIQDEVANYYHISFSDLVGPKRPKEIAFPRQIAMYLVRELLGTSLPAIGTAFG
HHHHHHHHHHHHHHHEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCC
GRDHTTVMYAYKQISDKMKNDMDVQKDIDSIKRKF
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ASLNENQKFWARVTELAQQSIGKQAYDFFIEPAQLMSVEQDTANILLDSGMKKDYWKKQ
CCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
SDLITTAGFEVFGRMIDYELYANDELTELELHRLNNQSSIEEQPRSTAKPASPLVSGLNE
HCEEHHHHHHHHHHHHCEEEECCCCCHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHCCC
KYNFENFVQGPGNRWTLAAAIAVADKPGDTYNPLFIYGGAGLGKTHLMHAIGNQILTDNP
CCCCHHHHCCCCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCEECCCC
TARIKYVSSENFVNDYVNATRKNQMENFENTYRNLDLLLLDDVQFFSDKEGTKNEFFNTF
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHCCCCCCHHHHHHHH
NALYDKGSQIVLTSDRIPQELNNLEDRLVSRFSWGLTTDITAPDYETRMAILLIKSESSR
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEECCCCC
LEFPSETLSYIAGQIDSNVRELEGALNRVEFVARANGIAVVDIETASQALRSLKNATQQS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHH
LSNLTIKKIQDEVANYYHISFSDLVGPKRPKEIAFPRQIAMYLVRELLGTSLPAIGTAFG
HHHHHHHHHHHHHHHEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCC
GRDHTTVMYAYKQISDKMKNDMDVQKDIDSIKRKF
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471