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The map label for this gene is purQ

Identifier: 15669844

GI number: 15669844

Start: 1629571

End: 1630263

Strand: Direct

Name: purQ

Synonym: MJ1648

Alternate gene names: 15669844

Gene position: 1629571-1630263 (Clockwise)

Preceding gene: 15669843

Following gene: 15669848

Centisome position: 97.87

GC content: 33.48

Gene sequence:

>693_bases
ATGAAGATAGCAGTGACAAAATTCTTAGGGACTAATTGTGATTTAGATGTATGTCATGCAGTTAAATTAGCTGGTGGAGA
GCCAGAACTTGTTTTCTTTACTCAAGAAAATTTAGATAGCTATAAAGGAGCAGTTATTCCAGGAGGATTTTCCTATGGGG
ATTATTTAAGAGCAGGAGCAATTAGTGCAAGAACTCCTATAATTAAAGGTCTAAAAAAGATGGTTGAAGAAGGAAAGCCA
GTTTTAGGAATATGTAATGGTGCTCAAATTGGTTTAGAGGCGGGATTTTCAAAAGGAACTTTGACAAACAACTTAAATGC
AAAATTTATCTGTAAATGGGTTTATATTAGGGTTGAAAATAACAAAACACCATTCACTCAATATTATAAAAAAGGAGAGG
TTTTAAAAATTCCTATCGCCCATGCTGAGGGAAGATTCTATGCAGATGATGAGACTTTAGATTATATGTATAAAAATAAC
ATGATTGTCTTTAAATACTGTGATGAAACTGGTGAAGTAACTGAAGAAGCAAATCCAAATGGTTCTATTGATAATATAGC
TGGAGTTTGCAATGAAAATCAAAACTGCGTTTTATTAATGCCACACCCAGAGAGAGCAAGTGAAAAGATTCTTGGTTCAG
ATGATGGGTTGAAAATGTTTAAGGGCATGATAGATTATGCTAAGAGGATTTAA

Upstream 100 bases:

>100_bases
CCTTCCATTAGGAAGGAGTTCATCAGTGCCTTAGTTATTACAAAATATTTTGAAAAGAACTATAGATTAATAACATCAGG
ATTAGTAACAAGGGGAGAGC

Downstream 100 bases:

>100_bases
TTCTTAACATAAAAGAAAATACATTTTAAATACTCAAGATTTTTATTTCCTATAGATATTGGATGGTCTGGAGCTTGTCC
TTTATAATCAATCATAATTA

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKIAVTKFLGTNCDLDVCHAVKLAGGEPELVFFTQENLDSYKGAVIPGGFSYGDYLRAGAISARTPIIKGLKKMVEEGKP
VLGICNGAQIGLEAGFSKGTLTNNLNAKFICKWVYIRVENNKTPFTQYYKKGEVLKIPIAHAEGRFYADDETLDYMYKNN
MIVFKYCDETGEVTEEANPNGSIDNIAGVCNENQNCVLLMPHPERASEKILGSDDGLKMFKGMIDYAKRI

Sequences:

>Translated_230_residues
MKIAVTKFLGTNCDLDVCHAVKLAGGEPELVFFTQENLDSYKGAVIPGGFSYGDYLRAGAISARTPIIKGLKKMVEEGKP
VLGICNGAQIGLEAGFSKGTLTNNLNAKFICKWVYIRVENNKTPFTQYYKKGEVLKIPIAHAEGRFYADDETLDYMYKNN
MIVFKYCDETGEVTEEANPNGSIDNIAGVCNENQNCVLLMPHPERASEKILGSDDGLKMFKGMIDYAKRI
>Mature_230_residues
MKIAVTKFLGTNCDLDVCHAVKLAGGEPELVFFTQENLDSYKGAVIPGGFSYGDYLRAGAISARTPIIKGLKKMVEEGKP
VLGICNGAQIGLEAGFSKGTLTNNLNAKFICKWVYIRVENNKTPFTQYYKKGEVLKIPIAHAEGRFYADDETLDYMYKNN
MIVFKYCDETGEVTEEANPNGSIDNIAGVCNENQNCVLLMPHPERASEKILGSDDGLKMFKGMIDYAKRI

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=234, Percent_Identity=28.2051282051282, Blast_Score=77, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17553022, Length=233, Percent_Identity=27.0386266094421, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=234, Percent_Identity=27.7777777777778, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24582111, Length=193, Percent_Identity=31.0880829015544, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24582109, Length=193, Percent_Identity=31.0880829015544, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137292, Length=193, Percent_Identity=31.0880829015544, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_METJA (Q59042)

Other databases:

- EMBL:   L77117
- PIR:   F64505
- RefSeq:   NP_248658.1
- ProteinModelPortal:   Q59042
- SMR:   Q59042
- GeneID:   1452557
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1648
- NMPDR:   fig|243232.1.peg.1695
- TIGR:   MJ1648
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   MJAN243232:MJ_1648-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR010075
- InterPro:   IPR002818
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF01965 DJ-1_PfpI

EC number: =6.3.5.3

Molecular weight: Translated: 25418; Mature: 25418

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 85-85 ACT_SITE 202-202 ACT_SITE 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVTKFLGTNCDLDVCHAVKLAGGEPELVFFTQENLDSYKGAVIPGGFSYGDYLRAGA
CEEEEEEECCCCCCHHHEEEEEECCCCCCEEEEECCCCCCCCCEEECCCCCCHHHHHHCC
ISARTPIIKGLKKMVEEGKPVLGICNGAQIGLEAGFSKGTLTNNLNAKFICKWVYIRVEN
CCCCCHHHHHHHHHHHCCCCEEEEECCCEECCCCCCCCCCEECCCCCEEEEEEEEEEEEC
NKTPFTQYYKKGEVLKIPIAHAEGRFYADDETLDYMYKNNMIVFKYCDETGEVTEEANPN
CCCCHHHHHCCCCEEEEEEEECCCCEEECCCCEEEEECCCEEEEEEECCCCCCCCCCCCC
GSIDNIAGVCNENQNCVLLMPHPERASEKILGSDDGLKMFKGMIDYAKRI
CCHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIAVTKFLGTNCDLDVCHAVKLAGGEPELVFFTQENLDSYKGAVIPGGFSYGDYLRAGA
CEEEEEEECCCCCCHHHEEEEEECCCCCCEEEEECCCCCCCCCEEECCCCCCHHHHHHCC
ISARTPIIKGLKKMVEEGKPVLGICNGAQIGLEAGFSKGTLTNNLNAKFICKWVYIRVEN
CCCCCHHHHHHHHHHHCCCCEEEEECCCEECCCCCCCCCCEECCCCCEEEEEEEEEEEEC
NKTPFTQYYKKGEVLKIPIAHAEGRFYADDETLDYMYKNNMIVFKYCDETGEVTEEANPN
CCCCHHHHHCCCCEEEEEEEECCCCEEECCCCEEEEECCCEEEEEEECCCCCCCCCCCCC
GSIDNIAGVCNENQNCVLLMPHPERASEKILGSDDGLKMFKGMIDYAKRI
CCHHHHHHHCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087