Click here to switch to the map view.

The map label for this gene is mch

Identifier: 15669832

GI number: 15669832

Start: 1617235

End: 1618206

Strand: Direct

Name: mch

Synonym: MJ1636

Alternate gene names: 15669832

Gene position: 1617235-1618206 (Clockwise)

Preceding gene: 15669831

Following gene: 15669833

Centisome position: 97.13

GC content: 36.93

Gene sequence:

>972_bases
ATGCTGAGTGTAAATAAAAAGGCATTAGAAATTGTAAATAAAATGATAGAAAATAAAGAAGAGATAAATATTGACGTCAT
AAAATTAGAAAATGGAGCTACTGTTTTGGACTGTGGAGTTAATGTCCCTGGAAGCTGGAAAGCTGGAAAGTTATTCACAA
AGATTTGTTTGGGAGGTTTAGCTCATGTTGGCATCTCCTTATCACCATGTGAGTGTAAAGGCATAACCTTACCTTATGTT
AAGATAAAGACATCACATCCAGCAATTGCTACATTGGGAGCTCAAAAGGCAGGATGGGCAGTTAAAGTTGGAAAATACTT
TGCTATGGGTTCAGGACCTGCAAGGGCTTTAGCTAAAAAGCCAAAAAAGACCTATGAAGAGATTGGCTATGAAGATGATG
CTGATGTTGCTGTTTTATGTTTAGAGGCTTCAAAATTGCCAAATGAAGAAGTTGCTGAATATGTAGCTAAAGAATGTGGT
GTTGAAGTAGAAAACGTTTATTTGTTAGTTGCTCCAACTGCTTCATTAGTTGGTTCAATCCAGATTAGTGGAAGAGTCGT
TGAGAACGGAACATACAAGATGTTAGAAGTTTTAGAGTTTGATGTTAATAAAGTTAAATATGCGGCAGGTTTAGCTCCAA
TTGCTCCAATAATAGGGGATGATTTCGCAATGATGGGAGCTACAAACGATATGGTATTGTATGGTGGGATAACCTACTAC
TACATTAAGAGTGATGAAAACGATGACATTGAAAGCTTATGCAAAGCTCTCCCATCTTGTGCTTCAAAAGATTATGGAAA
ACCATTCATGGAAGTGTTTAAAGCTGCTGATTACGACTTCTACAAGATTGACAAAGGAATGTTTGCTCCAGCTGTGGTTG
TAATTAACGATATGACAACTGGAAAAGTCTATAGAGCTGGAAAGGTCAATGCAGAAGTCCTTAAAAAATCATTAGGCTGG
ACAGAGTTATAA

Upstream 100 bases:

>100_bases
AGATTATAACGGAAAATATTTTAATGAAATTGCCTAAATATCTATAATTGACCATGTTGGGAGAACCCCATATAAAGCTA
CATGTTCCATTGGTGATAAG

Downstream 100 bases:

>100_bases
AAAACTTTTTTTAATTTTAATTATCTAATATTTTTGCTATTTTTTAGGTATTAAAATGATTAGAGCTTTTTTAGTTTTCC
CATACCTTTATATATTGGTT

Product: N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase

Products: NA

Alternate protein names: Methenyl-H4MPT cyclohydrolase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MLSVNKKALEIVNKMIENKEEINIDVIKLENGATVLDCGVNVPGSWKAGKLFTKICLGGLAHVGISLSPCECKGITLPYV
KIKTSHPAIATLGAQKAGWAVKVGKYFAMGSGPARALAKKPKKTYEEIGYEDDADVAVLCLEASKLPNEEVAEYVAKECG
VEVENVYLLVAPTASLVGSIQISGRVVENGTYKMLEVLEFDVNKVKYAAGLAPIAPIIGDDFAMMGATNDMVLYGGITYY
YIKSDENDDIESLCKALPSCASKDYGKPFMEVFKAADYDFYKIDKGMFAPAVVVINDMTTGKVYRAGKVNAEVLKKSLGW
TEL

Sequences:

>Translated_323_residues
MLSVNKKALEIVNKMIENKEEINIDVIKLENGATVLDCGVNVPGSWKAGKLFTKICLGGLAHVGISLSPCECKGITLPYV
KIKTSHPAIATLGAQKAGWAVKVGKYFAMGSGPARALAKKPKKTYEEIGYEDDADVAVLCLEASKLPNEEVAEYVAKECG
VEVENVYLLVAPTASLVGSIQISGRVVENGTYKMLEVLEFDVNKVKYAAGLAPIAPIIGDDFAMMGATNDMVLYGGITYY
YIKSDENDDIESLCKALPSCASKDYGKPFMEVFKAADYDFYKIDKGMFAPAVVVINDMTTGKVYRAGKVNAEVLKKSLGW
TEL
>Mature_323_residues
MLSVNKKALEIVNKMIENKEEINIDVIKLENGATVLDCGVNVPGSWKAGKLFTKICLGGLAHVGISLSPCECKGITLPYV
KIKTSHPAIATLGAQKAGWAVKVGKYFAMGSGPARALAKKPKKTYEEIGYEDDADVAVLCLEASKLPNEEVAEYVAKECG
VEVENVYLLVAPTASLVGSIQISGRVVENGTYKMLEVLEFDVNKVKYAAGLAPIAPIIGDDFAMMGATNDMVLYGGITYY
YIKSDENDDIESLCKALPSCASKDYGKPFMEVFKAADYDFYKIDKGMFAPAVVVINDMTTGKVYRAGKVNAEVLKKSLGW
TEL

Specific function: Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(+)

COG id: COG3252

COG function: function code H; Methenyltetrahydromethanopterin cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MCH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MCH_METJA (Q59030)

Other databases:

- EMBL:   L77117
- PIR:   B64504
- RefSeq:   NP_248646.1
- ProteinModelPortal:   Q59030
- SMR:   Q59030
- GeneID:   1452545
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1636
- NMPDR:   fig|243232.1.peg.1683
- TIGR:   MJ1636
- HOGENOM:   HBG497176
- OMA:   YFAMGSG
- ProtClustDB:   PRK02264
- BioCyc:   MJAN243232:MJ_1636-MONOMER
- BRENDA:   3.5.4.27
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_00486
- InterPro:   IPR003209
- TIGRFAMs:   TIGR03120

Pfam domain/function: PF02289 MCH; SSF56199 Cyclohydrolase

EC number: =3.5.4.27

Molecular weight: Translated: 34900; Mature: 34900

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVNKKALEIVNKMIENKEEINIDVIKLENGATVLDCGVNVPGSWKAGKLFTKICLGGL
CCCCCHHHHHHHHHHHCCHHHCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
AHVGISLSPCECKGITLPYVKIKTSHPAIATLGAQKAGWAVKVGKYFAMGSGPARALAKK
HHHCCCCCCCCCCCEEECEEEEECCCCCEEECCCCCCCCEEEECCEEEECCCHHHHHHHC
PKKTYEEIGYEDDADVAVLCLEASKLPNEEVAEYVAKECGVEVENVYLLVAPTASLVGSI
HHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEEEEEEECHHHHHEEE
QISGRVVENGTYKMLEVLEFDVNKVKYAAGLAPIAPIIGDDFAMMGATNDMVLYGGITYY
EEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCCCEEEECCEEEE
YIKSDENDDIESLCKALPSCASKDYGKPFMEVFKAADYDFYKIDKGMFAPAVVVINDMTT
EEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCC
GKVYRAGKVNAEVLKKSLGWTEL
CCEEECCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MLSVNKKALEIVNKMIENKEEINIDVIKLENGATVLDCGVNVPGSWKAGKLFTKICLGGL
CCCCCHHHHHHHHHHHCCHHHCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
AHVGISLSPCECKGITLPYVKIKTSHPAIATLGAQKAGWAVKVGKYFAMGSGPARALAKK
HHHCCCCCCCCCCCEEECEEEEECCCCCEEECCCCCCCCEEEECCEEEECCCHHHHHHHC
PKKTYEEIGYEDDADVAVLCLEASKLPNEEVAEYVAKECGVEVENVYLLVAPTASLVGSI
HHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEEEEEEECHHHHHEEE
QISGRVVENGTYKMLEVLEFDVNKVKYAAGLAPIAPIIGDDFAMMGATNDMVLYGGITYY
EEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEECCCCCEEEECCEEEE
YIKSDENDDIESLCKALPSCASKDYGKPFMEVFKAADYDFYKIDKGMFAPAVVVINDMTT
EEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCC
GKVYRAGKVNAEVLKKSLGWTEL
CCEEECCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087