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The map label for this gene is pyrC

Identifier: 15669684

GI number: 15669684

Start: 1464324

End: 1465595

Strand: Direct

Name: pyrC

Synonym: MJ1490

Alternate gene names: 15669684

Gene position: 1464324-1465595 (Clockwise)

Preceding gene: 15669683

Following gene: 15669685

Centisome position: 87.95

GC content: 28.38

Gene sequence:

>1272_bases
ATGCTATTAAAAAACTGTAGAATAATAAAAGACAACAAAATCATTGAAGGAGATATTTTAATTGATGAAAATGGTAGAAT
CAAAAAGATAGCCAAAGATATTAAAGTAGATGATGAAATAATAGATATAAAAAACTCCTTAGTTATTCCGGGAGTTATTG
ATGCACATGTTCATTTTAGATGGGGAGAGGAAAAGAAGGAAGATTTTTTAAGTGGTAGCTTAGCTGGAATAAATGGAGGA
GTTTGCTTTGCCATAGACATGCCTAATAATAAACCTCCAATAACTACAAAAGAACTATTTTATAAAAAACTTGAAGATTG
TAAAAAGGATAGTAAGATAAATGTGTTTTTGAATTTTGGAGTTACTGAAAATAATTACCTTGGAACTGTAGAAGATGCAA
AAGCATACAAGATATTTATGGTTAAATCTGTTGGAGATTTGTTTATAGAGGATTATTCAAAATTAAAAGATATTTTAAAT
CAAAATAAGCTTTTCTGCATCCATGCTGAACACAAAGATGTAATAAATGAAAATCTAAAGAAATATCAATTAAACAGCTG
GATAGACCATTGTAAAATTAGGGATGAAAAATCAGAAGTTGAAGCAGTTAAAGAAGTTATAAAAAACTTAAAGATTATTG
ATAGGCAGAGTAATAAAAAACCACATGTCCATTTTTGCCATATTTCAACTAAAGAAGCTCTATATTTAATAAAAAAAGTA
AGACAAGAGTTAAAAAATATAAAAATAACTGTTGAAGTTACTCCCCATCATATTTATTTAAATAAAGACATGGCTGAAGA
GTTAAAGGGTTTTGGCAAGTTTAACCCTCCATTAAGAGAAAAAGATGATAATATCGCTTTAATTAAAGGAATTGTTAATA
AAGATGTTGATATTATTGCCTCTGACCACGCCCCACATTTATTAGAGGATAAACTTAAAAATGTCAAAAACTGCCCTTCG
GGGATTCCAGGAATTGAGACGATAGTTCCTTTAACCTTAAATTTAGTTAATAAAGGATTAATAAGTTTGTTTGATGCTAT
AAGGGTTTTATCAAAAAATCCTGCTAAGATATTTAACATAAACAACAAAATTGAAGAAGGCAATTTAGCAAATCTAACAA
TTATTGATTTAAAAAAAGAAGGAAAAATCAATGCTGAACTGTTTAAATCAAAGGCAAAATTTAGTCCATTTGACGGATGG
GAAGTTAAGGGATTTCCAATCTATACAGTGATTAATGGAACTTTGTATGAAGCTTATGGATGTAAATGTTAA

Upstream 100 bases:

>100_bases
GCATAACTACCAGCCTCTAAACTCTTAAAGATGGTTAATATTTTTATTTAATACTTTTTATTTTTATTAGTTTTGTATTA
ATAAATTAAGATGTGATACC

Downstream 100 bases:

>100_bases
TAATATAAAAATAGAAAAATATATAAAATCAAAAAATAAAAATTTTAATGTAATTATAATTAAAAATAAACTCGGTGAAA
TATATGGTAAGTTTTGACCA

Product: dihydroorotase PyrC

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLLKNCRIIKDNKIIEGDILIDENGRIKKIAKDIKVDDEIIDIKNSLVIPGVIDAHVHFRWGEEKKEDFLSGSLAGINGG
VCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFGVTENNYLGTVEDAKAYKIFMVKSVGDLFIEDYSKLKDILN
QNKLFCIHAEHKDVINENLKKYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKV
RQELKNIKITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDIIASDHAPHLLEDKLKNVKNCPS
GIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFNINNKIEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGW
EVKGFPIYTVINGTLYEAYGCKC

Sequences:

>Translated_423_residues
MLLKNCRIIKDNKIIEGDILIDENGRIKKIAKDIKVDDEIIDIKNSLVIPGVIDAHVHFRWGEEKKEDFLSGSLAGINGG
VCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFGVTENNYLGTVEDAKAYKIFMVKSVGDLFIEDYSKLKDILN
QNKLFCIHAEHKDVINENLKKYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKV
RQELKNIKITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDIIASDHAPHLLEDKLKNVKNCPS
GIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFNINNKIEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGW
EVKGFPIYTVINGTLYEAYGCKC
>Mature_423_residues
MLLKNCRIIKDNKIIEGDILIDENGRIKKIAKDIKVDDEIIDIKNSLVIPGVIDAHVHFRWGEEKKEDFLSGSLAGINGG
VCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFGVTENNYLGTVEDAKAYKIFMVKSVGDLFIEDYSKLKDILN
QNKLFCIHAEHKDVINENLKKYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKV
RQELKNIKITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDIIASDHAPHLLEDKLKNVKNCPS
GIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFNINNKIEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGW
EVKGFPIYTVINGTLYEAYGCKC

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=30.4123711340206, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI4503379, Length=444, Percent_Identity=24.3243243243243, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI4503051, Length=448, Percent_Identity=24.5535714285714, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI62422571, Length=447, Percent_Identity=24.1610738255034, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786722, Length=436, Percent_Identity=24.5412844036697, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI87082175, Length=451, Percent_Identity=21.7294900221729, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=373, Percent_Identity=27.8820375335121, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322218, Length=397, Percent_Identity=25.1889168765743, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24642586, Length=399, Percent_Identity=30.0751879699248, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=24.6153846153846, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_METJA (Q58885)

Other databases:

- EMBL:   L77117
- PIR:   A64486
- RefSeq:   NP_248497.1
- ProteinModelPortal:   Q58885
- MEROPS:   M38.972
- GeneID:   1452397
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1490
- NMPDR:   fig|243232.1.peg.1534
- TIGR:   MJ1490
- HOGENOM:   HBG724623
- OMA:   AEHKDVI
- ProtClustDB:   CLSK876595
- BioCyc:   MJAN243232:MJ_1490-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_A
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 48105; Mature: 48105

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKNCRIIKDNKIIEGDILIDENGRIKKIAKDIKVDDEIIDIKNSLVIPGVIDAHVHFR
CCCCCCEEEECCEEEECEEEECCCCCHHHHHHHCCCCCHHEECCCCEECCCEEEEEEEEE
WGEEKKEDFLSGSLAGINGGVCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFG
ECCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEC
VTENNYLGTVEDAKAYKIFMVKSVGDLFIEDYSKLKDILNQNKLFCIHAEHKDVINENLK
CCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
KYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEECCCCCCCCEEEEEECHHHHHHHHHHH
RQELKNIKITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDIIA
HHHHCCEEEEEEECCCEEEECCHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHCCCCEEEE
SDHAPHLLEDKLKNVKNCPSGIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFNI
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
NNKIEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGWEVKGFPIYTVINGTLYEAYG
CCCCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCEECCEEEEEEECCEEEECCC
CKC
CCC
>Mature Secondary Structure
MLLKNCRIIKDNKIIEGDILIDENGRIKKIAKDIKVDDEIIDIKNSLVIPGVIDAHVHFR
CCCCCCEEEECCEEEECEEEECCCCCHHHHHHHCCCCCHHEECCCCEECCCEEEEEEEEE
WGEEKKEDFLSGSLAGINGGVCFAIDMPNNKPPITTKELFYKKLEDCKKDSKINVFLNFG
ECCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEC
VTENNYLGTVEDAKAYKIFMVKSVGDLFIEDYSKLKDILNQNKLFCIHAEHKDVINENLK
CCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
KYQLNSWIDHCKIRDEKSEVEAVKEVIKNLKIIDRQSNKKPHVHFCHISTKEALYLIKKV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEECCCCCCCCEEEEEECHHHHHHHHHHH
RQELKNIKITVEVTPHHIYLNKDMAEELKGFGKFNPPLREKDDNIALIKGIVNKDVDIIA
HHHHCCEEEEEEECCCEEEECCHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHCCCCEEEE
SDHAPHLLEDKLKNVKNCPSGIPGIETIVPLTLNLVNKGLISLFDAIRVLSKNPAKIFNI
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
NNKIEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGWEVKGFPIYTVINGTLYEAYG
CCCCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCCCCCCEECCEEEEEEECCEEEECCC
CKC
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087