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The map label for this gene is hisD

Identifier: 15669647

GI number: 15669647

Start: 1425716

End: 1427005

Strand: Direct

Name: hisD

Synonym: MJ1456

Alternate gene names: 15669647

Gene position: 1425716-1427005 (Clockwise)

Preceding gene: 15669644

Following gene: 15669648

Centisome position: 85.63

GC content: 33.33

Gene sequence:

>1290_bases
ATGGTGACTGGAATGATAATTAAAAAAATTAAAGAATTAACAAAGGAAGAAGAGGAGAAAATAATTAATAGGAATAAAGC
AAACTTTGAGGAAATATTGCCAACAGTAATGGAGATTTTGAAGGATGTTAAAGAAAAAGGGGATGAAGCATTAAAATATT
ATACAAAAAAGTTCGATGGTGTAGAAATAGAAGATTTTAAAGTTACAGATGAGGAGATAGAAGAAGCTTATAACTCAGTT
GATTATAAAGTTGTTGAAGCTATTGAGAGAGCTAAGGAAAACATTTATTTCTTCCATAAAAAGCAGATGGAGCAAATAAA
AGATTTAAATGTTGAAAATAATGGAATAATTTTAGGACAGGTTGTTAGAGCAATAGAAAAAGTTGGATGCTATGTTCCTG
GAGGAAGGGCATTTTATCCTTCAACTGTTTTAATGACAACAATTCCTGCAAAGGTTGCTGGATGTGAAGAGATATATATA
ACCTCCCCACCTACAAAAGATGGGAAAGGAAATCCAGCTACCTTAATAGCAGGAGATATTGTTGGAGTTTCAGCTATTTA
TAAGGTTGGAGGAGTTCAAGCTATAGGGGCATTAGCCTATGGAACAGAGACTATCCCAAAGGTTGATATTATTGTAGGGC
CTGGGAATATATATGTAACAACAGCTAAAAAGATGGTTTATGGAGAAGTTGCCATAGATTTCTTAGCAGGTCCTTCAGAG
GTTTTAATTATTGCTGATGAAACAGCTAATGCAGAGTTTGTTGCCTTAGATTTTATTGCCCAAGCTGAACACGACCCTAA
CGCCTCTTGTGTAATAACAACAACATCTGAAAAGAAGGCAGAGGAGATTAAAAACAAGATATTTGAAGAGATAGAAAAAG
CTGAAAGAAAGGAGATTATTTTAAAAGCCTTAGAAAACTCTGCCATATTAATTGGTGATTTAGAAGAGTGTATTGAATTC
TCAAATAAATATGCCCCAGAACATCTTGAAATATTAACTAAAAATCCAGAGGAAGTTTTAAATAAAATTAAACATGCTGG
AAGTGTATTTTTAGGAGAGTATAGCCCAGTTCCTGTTGGAGATTATGCTTCTGGAACTAATCATGTTCTGCCAACTTCAC
AGTTTGCGAGAATGAGTTCTGGTTTGAATGTAGAGACATTTTTAAAGAAAATAACATATCAAAAATTGGATAAGGAAAGC
TTAAAAAATATTGCTGATATTGTTATCACATTAGCTGAAGCTGAAGGTTTGTTTGGGCATGCTGAAGCTGTTAGAAGAAG
ATTAAAATAA

Upstream 100 bases:

>100_bases
GTTCCCCACTCGAAGAGTATCATTTTCTCACCTTGATTTTTTCTTATACAGTAAATAATATAAGCACTGACTATATATAA
ACTTTGTCAATTAAAAATCT

Downstream 100 bases:

>100_bases
TTTTTATGTGATGGTTATGACAGCACTAACCTTATTAATTTTATTTTTTGGATTAGCATTTATTTTAGTTGGTTTTGGAT
TGATACTGGGATATTTAATA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDGVEIEDFKVTDEEIEEAYNSV
DYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQVVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYI
TSPPTKDGKGNPATLIAGDIVGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEVAIDFLAGPSE
VLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERKEIILKALENSAILIGDLEECIEF
SNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKES
LKNIADIVITLAEAEGLFGHAEAVRRRLK

Sequences:

>Translated_429_residues
MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDGVEIEDFKVTDEEIEEAYNSV
DYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQVVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYI
TSPPTKDGKGNPATLIAGDIVGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEVAIDFLAGPSE
VLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERKEIILKALENSAILIGDLEECIEF
SNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKES
LKNIADIVITLAEAEGLFGHAEAVRRRLK
>Mature_429_residues
MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDGVEIEDFKVTDEEIEEAYNSV
DYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQVVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYI
TSPPTKDGKGNPATLIAGDIVGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEVAIDFLAGPSE
VLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERKEIILKALENSAILIGDLEECIEF
SNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKES
LKNIADIVITLAEAEGLFGHAEAVRRRLK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=421, Percent_Identity=42.0427553444181, Blast_Score=326, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=43.436754176611, Blast_Score=325, Evalue=9e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_METJA (Q58851)

Other databases:

- EMBL:   L77117
- PIR:   G64481
- RefSeq:   NP_248460.1
- ProteinModelPortal:   Q58851
- SMR:   Q58851
- GeneID:   1452360
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1456
- NMPDR:   fig|243232.1.peg.1497
- TIGR:   MJ1456
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   MJAN243232:MJ_1456-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47433; Mature: 47433

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 327-327 ACT_SITE 328-328 BINDING 131-131 BINDING 193-193 BINDING 216-216 BINDING 239-239 BINDING 261-261 BINDING 264-264 BINDING 328-328 BINDING 361-361 BINDING 415-415 BINDING 420-420

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VEIEDFKVTDEEIEEAYNSVDYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQ
CEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCEEEEHHHHHHHHHHCCCCCCCEEHHH
VVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYITSPPTKDGKGNPATLIAGDI
HHHHHHHCCCCCCCCCCCCCCHHEEEECCHHHCCCCEEEEECCCCCCCCCCCCEEEECCH
VGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEVAIDFLAGPSE
HHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHEECCCCE
VLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERKEII
EEEEEECCCCCCEEEEEHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LKALENSAILIGDLEECIEFSNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVG
HHHHCCCEEEEECHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHCCCEEECCCCCCCCC
DYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKESLKNIADIVITLAEAEGLFGH
CCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
AEAVRRRLK
HHHHHHHCC
>Mature Secondary Structure
MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VEIEDFKVTDEEIEEAYNSVDYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQ
CEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCEEEEHHHHHHHHHHCCCCCCCEEHHH
VVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYITSPPTKDGKGNPATLIAGDI
HHHHHHHCCCCCCCCCCCCCCHHEEEECCHHHCCCCEEEEECCCCCCCCCCCCEEEECCH
VGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEVAIDFLAGPSE
HHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHEECCCCE
VLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERKEII
EEEEEECCCCCCEEEEEHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LKALENSAILIGDLEECIEFSNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVG
HHHHCCCEEEEECHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHCCCEEECCCCCCCCC
DYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKESLKNIADIVITLAEAEGLFGH
CCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
AEAVRRRLK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087