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The map label for this gene is trpS

Identifier: 15669605

GI number: 15669605

Start: 1375878

End: 1376990

Strand: Direct

Name: trpS

Synonym: MJ1415

Alternate gene names: 15669605

Gene position: 1375878-1376990 (Clockwise)

Preceding gene: 15669602

Following gene: 15669607

Centisome position: 82.64

GC content: 33.42

Gene sequence:

>1113_bases
GTGAAACTAATGGAATTAACACCATGGGAAACTCCAGCAGTTATTGATTACAAAAAGACGATGGAGCAGTTTGGAGTTAA
GCCAATAGTTGATGTTTTAGGAGATTTGAAAGAGGAACATCATTTCTTCAGGAGGAATATTATATTGGGGCATAGGGATT
TTGAGAGAATAGTTGATGCAATAAAAAATAACAAAGAGTTTGCAGTTGTTAGTGGAATGATGCCTTCTGGTAAAATGCAT
TTTGGGCATAAAATGGTGGTAGATTTATTAAAGTTTTATCAAAAATACACTGACAATATAAACATCCCAATAGCTGATTT
AGAGGCATATTGGGCAAGAAACATGAGCTTTGAAACAACAAAAGAACTTGCTTTAAATGAGTATATAACCAACTACATAG
CTCTTGGCTTAGACCCAGAAAAAATTAATGTGTATTTACAATCAAAATATCAAAAGGTTAAAGATTTGGCTTTAATTTTA
TCTAAAAGAACAAATTGGAGTGAGATGAAGGCAATTTATGGATTTAAAGGAGAAACAAACATTGGACACGTCTTTGCCCC
AATAGTTCAAGTTGCTGATATTTTACATCCTCAACTTGATGAGAACTTAAGTCCAGAACCAAAACCCGTTGTTGTTCCAG
TAGGAATTGACCAAGACCCGCATATAAGATTAACAAGAGATATTGCAAATAGAGCTAAGGAGTTTAAGTTTATTCCTCCA
TCTTCAACCTATCACAGATTTATGACTGGATTGTTAGGAGGAAAAATGAGTTCTTCAAAGCCAGAGACAGCAATATTTTT
GACTGATGATGAAAAAACTGTTAAAAAGAAAATATTCTCAGCAAAAACTGGGGGAAGAGAGACTTTAGAAGAGCATAAGA
AGTATGGGGGAGTTCCAGAGGAATGTGTTGTTTATGAGTTGTTTTTATATCACTTAATCTTAGATGATAAGGAATTAGCT
GAAATATATCAAAAATGTAGAAGTGGAGAACTAACTTGTGGTAAATGCAAAAAAATGGCTTATGAAAGAGTTGTAGAGTT
TTTAAAAGATTTGAAGGAGAAGAGAGAGCAAGCAAAGGAAATTGCTGTAAAAATCTTGGAAGGAAAGTATTAA

Upstream 100 bases:

>100_bases
AAACCAAAAATATTGCCCACCTCATAGGTGACACCTTAAAGAGAATACATAATAAATATATTACAACTGATGTATTTAAA
TCTTTATATCAAAATGAAGG

Downstream 100 bases:

>100_bases
AATTTCTTTTTTCTCTCTTTTAACAATTCAACAACAAAATCTTTCTTTTTAATAGCTTCATCACATGCTCTCCTAACTTT
CTCCTTCATCTCCTCAAAAT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKLMELTPWETPAVIDYKKTMEQFGVKPIVDVLGDLKEEHHFFRRNIILGHRDFERIVDAIKNNKEFAVVSGMMPSGKMH
FGHKMVVDLLKFYQKYTDNINIPIADLEAYWARNMSFETTKELALNEYITNYIALGLDPEKINVYLQSKYQKVKDLALIL
SKRTNWSEMKAIYGFKGETNIGHVFAPIVQVADILHPQLDENLSPEPKPVVVPVGIDQDPHIRLTRDIANRAKEFKFIPP
SSTYHRFMTGLLGGKMSSSKPETAIFLTDDEKTVKKKIFSAKTGGRETLEEHKKYGGVPEECVVYELFLYHLILDDKELA
EIYQKCRSGELTCGKCKKMAYERVVEFLKDLKEKREQAKEIAVKILEGKY

Sequences:

>Translated_370_residues
MKLMELTPWETPAVIDYKKTMEQFGVKPIVDVLGDLKEEHHFFRRNIILGHRDFERIVDAIKNNKEFAVVSGMMPSGKMH
FGHKMVVDLLKFYQKYTDNINIPIADLEAYWARNMSFETTKELALNEYITNYIALGLDPEKINVYLQSKYQKVKDLALIL
SKRTNWSEMKAIYGFKGETNIGHVFAPIVQVADILHPQLDENLSPEPKPVVVPVGIDQDPHIRLTRDIANRAKEFKFIPP
SSTYHRFMTGLLGGKMSSSKPETAIFLTDDEKTVKKKIFSAKTGGRETLEEHKKYGGVPEECVVYELFLYHLILDDKELA
EIYQKCRSGELTCGKCKKMAYERVVEFLKDLKEKREQAKEIAVKILEGKY
>Mature_370_residues
MKLMELTPWETPAVIDYKKTMEQFGVKPIVDVLGDLKEEHHFFRRNIILGHRDFERIVDAIKNNKEFAVVSGMMPSGKMH
FGHKMVVDLLKFYQKYTDNINIPIADLEAYWARNMSFETTKELALNEYITNYIALGLDPEKINVYLQSKYQKVKDLALIL
SKRTNWSEMKAIYGFKGETNIGHVFAPIVQVADILHPQLDENLSPEPKPVVVPVGIDQDPHIRLTRDIANRAKEFKFIPP
SSTYHRFMTGLLGGKMSSSKPETAIFLTDDEKTVKKKIFSAKTGGRETLEEHKKYGGVPEECVVYELFLYHLILDDKELA
EIYQKCRSGELTCGKCKKMAYERVVEFLKDLKEKREQAKEIAVKILEGKY

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI47419920, Length=384, Percent_Identity=29.6875, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI47419918, Length=384, Percent_Identity=29.6875, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI47419916, Length=384, Percent_Identity=29.6875, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI47419914, Length=384, Percent_Identity=29.6875, Blast_Score=155, Evalue=5e-38,
Organism=Escherichia coli, GI1789786, Length=240, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72001474, Length=369, Percent_Identity=30.3523035230352, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324475, Length=381, Percent_Identity=32.0209973753281, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320474, Length=266, Percent_Identity=27.8195488721804, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17864462, Length=386, Percent_Identity=30.0518134715026, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24645295, Length=386, Percent_Identity=30.0518134715026, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_METJA (Q58810)

Other databases:

- EMBL:   L77117
- PIR:   F64476
- RefSeq:   NP_248418.1
- ProteinModelPortal:   Q58810
- SMR:   Q58810
- GeneID:   1452318
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1415
- NMPDR:   fig|243232.1.peg.1455
- TIGR:   MJ1415
- HOGENOM:   HBG435805
- OMA:   ADILHPQ
- ProtClustDB:   PRK12285
- BioCyc:   MJAN243232:MJ_1415-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_A
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- InterPro:   IPR020653
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 42661; Mature: 42661

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLMELTPWETPAVIDYKKTMEQFGVKPIVDVLGDLKEEHHFFRRNIILGHRDFERIVDA
CCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHH
IKNNKEFAVVSGMMPSGKMHFGHKMVVDLLKFYQKYTDNINIPIADLEAYWARNMSFETT
HHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHH
KELALNEYITNYIALGLDPEKINVYLQSKYQKVKDLALILSKRTNWSEMKAIYGFKGETN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
IGHVFAPIVQVADILHPQLDENLSPEPKPVVVPVGIDQDPHIRLTRDIANRAKEFKFIPP
CHHHHHHHHHHHHHHCHHHCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCCCCC
SSTYHRFMTGLLGGKMSSSKPETAIFLTDDEKTVKKKIFSAKTGGRETLEEHKKYGGVPE
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
ECVVYELFLYHLILDDKELAEIYQKCRSGELTCGKCKKMAYERVVEFLKDLKEKREQAKE
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVKILEGKY
HHHHHHCCCC
>Mature Secondary Structure
MKLMELTPWETPAVIDYKKTMEQFGVKPIVDVLGDLKEEHHFFRRNIILGHRDFERIVDA
CCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHH
IKNNKEFAVVSGMMPSGKMHFGHKMVVDLLKFYQKYTDNINIPIADLEAYWARNMSFETT
HHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHH
KELALNEYITNYIALGLDPEKINVYLQSKYQKVKDLALILSKRTNWSEMKAIYGFKGETN
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
IGHVFAPIVQVADILHPQLDENLSPEPKPVVVPVGIDQDPHIRLTRDIANRAKEFKFIPP
CHHHHHHHHHHHHHHCHHHCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCCCCC
SSTYHRFMTGLLGGKMSSSKPETAIFLTDDEKTVKKKIFSAKTGGRETLEEHKKYGGVPE
CHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
ECVVYELFLYHLILDDKELAEIYQKCRSGELTCGKCKKMAYERVVEFLKDLKEKREQAKE
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVKILEGKY
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087