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The map label for this gene is mre11

Identifier: 15669513

GI number: 15669513

Start: 1273384

End: 1274484

Strand: Reverse

Name: mre11

Synonym: MJ1323

Alternate gene names: 15669513

Gene position: 1274484-1273384 (Counterclockwise)

Preceding gene: 15669521

Following gene: 15669512

Centisome position: 76.55

GC content: 28.34

Gene sequence:

>1101_bases
ATGATGTTCGTTCATATAGCTGATAATCACTTAGGTTATAGACAGTATAACTTGGATGATAGGGAAAAAGATATTTACGA
CTCATTTAAATTATGTATAAAAAAGATTTTAGAGATAAAGCCAGATGTTGTTTTACATAGTGGTGATTTATTTAACGATT
TGAGACCTCCAGTAAAAGCTTTAAGAATAGCTATGCAGGCGTTTAAAAAATTACATGAAAATAATATAAAGGTTTATATT
GTTGCAGGAAACCATGAAATGCCAAGAAGGTTAGGGGAGGAATCTCCATTAGCCTTACTAAAAGATTACGTTAAAATTTT
AGATGGAAAAGATGTTATAAATGTAAATGGGGAAGAGATATTTATCTGTGGGACTTATTATCACAAAAAGAGCAAAAGAG
AGGAGATGTTAGATAAATTAAAAAATTTTGAATCAGAAGCTAAAAACTATAAAAAAAAGATATTGATGCTTCATCAGGGA
ATAAATCCATATATTCCACTTGACTATGAACTTGAACATTTTGATTTACCAAAATTTTCCTACTATGCGTTGGGACATAT
TCACAAGAGGATTTTAGAGAGGTTTAATGATGGAATTTTAGCTTACAGTGGTTCAACAGAAATTATTTATAGAAATGAAT
ATGAGGACTATAAAAAAGAAGGAAAAGGATTTTACTTAGTTGATTTTAGTGGAAATGATTTGGATATCTCTGATATAGAA
AAAATTGATATTGAATGCAGAGAATTTGTAGAGGTAAATATTAAAGATAAGAAATCTTTTAATGAGGCAGTGAATAAAAT
TGAAAGATGTAAAAATAAGCCAGTTGTTTTTGGAAAAATTAAGAGAGAATTTAAACCATGGTTTGACACTTTAAAGGATA
AAATTCTAATTAATAAAGCTATTATAGTAGATGACGAATTTATAGACATGCCAGATAATGTTGATATTGAGTCACTAAAC
ATTAAAGAGCTTTTAGTGGATTATGCAAATAGGCAGGGAATTGATGGGGATTTAGTTTTAAGTTTATATAAAGCTCTATT
AAATAATGAAAATTGGAAAGAGTTATTGGATGAATATTACAACACTAAATTTAGGGGATGA

Upstream 100 bases:

>100_bases
TCTCATGTTATCACCATAAATATAAAAACTGTAGGTTTAACATATTTAAATTTTATGCATTAATTATTCTATCACAAAAT
AAAAATTTGAGGGATAGTAT

Downstream 100 bases:

>100_bases
GTATGATACTAAAAGAAATAAGGATGAATAACTTTAAAAGTCATGTGAATTCAAGAATTAAGTTTGAAAAAGGGATTGTT
GCAATTATTGGAGAGAATGG

Product: DNA repair protein RAD32

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYI
VAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQG
INPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIE
KIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLN
IKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG

Sequences:

>Translated_366_residues
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYI
VAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQG
INPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIE
KIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLN
IKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG
>Mature_366_residues
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHENNIKVYI
VAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEIFICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQG
INPYIPLDYELEHFDLPKFSYYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIE
KIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKAIIVDDEFIDMPDNVDIESLN
IKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYYNTKFRG

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRE11_METJA (Q58719)

Other databases:

- EMBL:   L77117
- PIR:   B64465
- RefSeq:   NP_248323.1
- ProteinModelPortal:   Q58719
- SMR:   Q58719
- GeneID:   1452225
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1323
- NMPDR:   fig|243232.1.peg.1360
- TIGR:   MJ1323
- HOGENOM:   HBG551298
- OMA:   ADNHLGY
- ProtClustDB:   CLSK876529
- BioCyc:   MJAN243232:MJ_1323-MONOMER
- InterPro:   IPR004843

Pfam domain/function: PF00149 Metallophos

EC number: NA

Molecular weight: Translated: 43132; Mature: 43132

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: ACT_SITE 85-85

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKA
CEEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCHHHH
LRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEI
HHHHHHHHHHHHHCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCEE
FICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQGINPYIPLDYELEHFDLPKFS
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
YYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIE
HHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHCCEEEEEEECCCCCCHHHHH
KIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKA
HHCCCCHHHEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHEEEE
IIVDDEFIDMPDNVDIESLNIKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYY
EEECCHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NTKFRG
CCCCCC
>Mature Secondary Structure
MMFVHIADNHLGYRQYNLDDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKA
CEEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCCHHHH
LRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLALLKDYVKILDGKDVINVNGEEI
HHHHHHHHHHHHHCCEEEEEEECCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCEE
FICGTYYHKKSKREEMLDKLKNFESEAKNYKKKILMLHQGINPYIPLDYELEHFDLPKFS
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
YYALGHIHKRILERFNDGILAYSGSTEIIYRNEYEDYKKEGKGFYLVDFSGNDLDISDIE
HHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHHCCEEEEEEECCCCCCHHHHH
KIDIECREFVEVNIKDKKSFNEAVNKIERCKNKPVVFGKIKREFKPWFDTLKDKILINKA
HHCCCCHHHEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHEEEE
IIVDDEFIDMPDNVDIESLNIKELLVDYANRQGIDGDLVLSLYKALLNNENWKELLDEYY
EEECCHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NTKFRG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087