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The map label for this gene is kefC [C]

Identifier: 15669461

GI number: 15669461

Start: 1218598

End: 1219764

Strand: Direct

Name: kefC [C]

Synonym: MJ1275

Alternate gene names: 15669461

Gene position: 1218598-1219764 (Clockwise)

Preceding gene: 15669459

Following gene: 15669466

Centisome position: 73.19

GC content: 30.42

Gene sequence:

>1167_bases
ATGGAAAGTTATTATTATGTGTTCTTCATAATATTATCAATAATCTTCATTGTGCCTAATCTATTAAAGAAGTTTAACAT
CCCTGCCATAACATCCATTATGATTGCAGGGATTATTATAGGTCCTTATGGGTTAAATATATTGCAGGTGGATGAGACAT
TAAAAATACTTGCAGATTTTGGAGCGATTATGTTAATGTTTTTAGCAGGACTTGAAGTAGATAATGAAACTTTAAAACAA
GAGTTTAAGAACTCCCTAATTTTAAGTTTATTCTCACTACTAATCCCTGGTGTTGGAGGTTACCTAATTGGGCAGTATTT
AGGTCTTGGATTTATTGGGAGTTTGTTATATGCTGTAATATTTGCGTCTCATTCTGTAGCAATTGTTTATGCAATATTAG
AAGAGCTGAAAATGGTTAAAACAAGATTGGGGACTATAATTTTAAGTGCTACAATTATCGTTGATTTATTTACTCTTCTT
TTATTATCAGTAGTTATAAAGTTAGGGATTGGTGGAGAGAATGTGGGAACATTCTTATTAGAGACAGTTTTATACATTGG
TGTGTTACTTTTAGCTATCCCATCACTATCCAAAAATATCCTTGGAGTATTTGAAAAGCTTCACGCTCAAAGAATACACT
ATGTTTTATTTATTATATTCATTGCCATAATAGTTGGGGAGGTTATTGGAATTCATCCAATAGTTGGGGCTTTTATCTGT
GGTGTTGCTGTTAGTGAAGCTTTAACTAAAGAAGAGCATGATGAACTTCTAAACAAAAATTTGAATGCAATTGGTTATGG
TTTCTTTATACCAATATTCTTCTTAGTTTTAGGAATGGAGACAAATATAAGAGTTATATTTAATTTAAGTAACTTAGAGC
TTTTATTAATCACACTAATTTCAGCAGTGGCGTTAAAATTTATCTCTGGTTTTATCGCTTTAAGAATTTTAGGTTTTGAT
AGAATAAAAAATACTATTGGAGGTTTATTAACAGTTCCAAAAATTTCAGCTTCGTTAGTAGCAGCATCAATTGGAAGAGA
ACTTGGTTTAATAGGAAATGAAATATTTGTAACAATTGTAGCTCTCTCTGTAATAACAGCTACAATAACTCCAATAGTGG
TGAAGCATATATTTGTTGCAAAATGTAATAAAAAAGCTAAAAATTAA

Upstream 100 bases:

>100_bases
CTTTCAAAACTTTTAGAATGACTAAGAATGGTTCCAGCAAAAGGGTTATATATTAAAATAGCCCTCTAACCTAAACAATT
AAAATTTTGATGGTGGGGTA

Downstream 100 bases:

>100_bases
TTTTTTTAAATCTTAATATCATCCATTCCTGATTTTAACTACAGGAAATCTCAATGAGAGTGATTTAGAGTTCATAAAGG
TTTCCATCCTCCAAGAGGTC

Product: Na(+)/H(+) antiporter NapA

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: MjNapA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MESYYYVFFIILSIIFIVPNLLKKFNIPAITSIMIAGIIIGPYGLNILQVDETLKILADFGAIMLMFLAGLEVDNETLKQ
EFKNSLILSLFSLLIPGVGGYLIGQYLGLGFIGSLLYAVIFASHSVAIVYAILEELKMVKTRLGTIILSATIIVDLFTLL
LLSVVIKLGIGGENVGTFLLETVLYIGVLLLAIPSLSKNILGVFEKLHAQRIHYVLFIIFIAIIVGEVIGIHPIVGAFIC
GVAVSEALTKEEHDELLNKNLNAIGYGFFIPIFFLVLGMETNIRVIFNLSNLELLLITLISAVALKFISGFIALRILGFD
RIKNTIGGLLTVPKISASLVAASIGRELGLIGNEIFVTIVALSVITATITPIVVKHIFVAKCNKKAKN

Sequences:

>Translated_388_residues
MESYYYVFFIILSIIFIVPNLLKKFNIPAITSIMIAGIIIGPYGLNILQVDETLKILADFGAIMLMFLAGLEVDNETLKQ
EFKNSLILSLFSLLIPGVGGYLIGQYLGLGFIGSLLYAVIFASHSVAIVYAILEELKMVKTRLGTIILSATIIVDLFTLL
LLSVVIKLGIGGENVGTFLLETVLYIGVLLLAIPSLSKNILGVFEKLHAQRIHYVLFIIFIAIIVGEVIGIHPIVGAFIC
GVAVSEALTKEEHDELLNKNLNAIGYGFFIPIFFLVLGMETNIRVIFNLSNLELLLITLISAVALKFISGFIALRILGFD
RIKNTIGGLLTVPKISASLVAASIGRELGLIGNEIFVTIVALSVITATITPIVVKHIFVAKCNKKAKN
>Mature_388_residues
MESYYYVFFIILSIIFIVPNLLKKFNIPAITSIMIAGIIIGPYGLNILQVDETLKILADFGAIMLMFLAGLEVDNETLKQ
EFKNSLILSLFSLLIPGVGGYLIGQYLGLGFIGSLLYAVIFASHSVAIVYAILEELKMVKTRLGTIILSATIIVDLFTLL
LLSVVIKLGIGGENVGTFLLETVLYIGVLLLAIPSLSKNILGVFEKLHAQRIHYVLFIIFIAIIVGEVIGIHPIVGAFIC
GVAVSEALTKEEHDELLNKNLNAIGYGFFIPIFFLVLGMETNIRVIFNLSNLELLLITLISAVALKFISGFIALRILGFD
RIKNTIGGLLTVPKISASLVAASIGRELGLIGNEIFVTIVALSVITATITPIVVKHIFVAKCNKKAKN

Specific function: This is probably a Na(+)/H(+) antiporter

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=375, Percent_Identity=27.7333333333333, Blast_Score=96, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAH3_METJA (Q58671)

Other databases:

- EMBL:   L77117
- PIR:   B64459
- RefSeq:   NP_248271.1
- ProteinModelPortal:   Q58671
- GeneID:   1452173
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1275
- NMPDR:   fig|243232.1.peg.1308
- TIGR:   MJ1275
- HOGENOM:   HBG541217
- OMA:   FFVEVGM
- ProtClustDB:   CLSK876514
- BioCyc:   MJAN243232:MJ_1275-MONOMER
- InterPro:   IPR006153

Pfam domain/function: PF00999 Na_H_Exchanger

EC number: NA

Molecular weight: Translated: 42181; Mature: 42181

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe6dab60)-; HASH(0xdd2f954)-; HASH(0xe76366c)-; HASH(0xe75c078)-; HASH(0xe62f0ec)-; HASH(0xe6707d0)-; HASH(0xddeaad4)-; HASH(0xe7cf028)-; HASH(0xe52a10c)-; HASH(0xe2ceb6c)-; HASH(0xd9e9a0c)-; HASH(0xe4e4194)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESYYYVFFIILSIIFIVPNLLKKFNIPAITSIMIAGIIIGPYGLNILQVDETLKILADF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHH
GAIMLMFLAGLEVDNETLKQEFKNSLILSLFSLLIPGVGGYLIGQYLGLGFIGSLLYAVI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FASHSVAIVYAILEELKMVKTRLGTIILSATIIVDLFTLLLLSVVIKLGIGGENVGTFLL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ETVLYIGVLLLAIPSLSKNILGVFEKLHAQRIHYVLFIIFIAIIVGEVIGIHPIVGAFIC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVAVSEALTKEEHDELLNKNLNAIGYGFFIPIFFLVLGMETNIRVIFNLSNLELLLITLI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
SAVALKFISGFIALRILGFDRIKNTIGGLLTVPKISASLVAASIGRELGLIGNEIFVTIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCHHHHHHHHH
ALSVITATITPIVVKHIFVAKCNKKAKN
HHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MESYYYVFFIILSIIFIVPNLLKKFNIPAITSIMIAGIIIGPYGLNILQVDETLKILADF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHH
GAIMLMFLAGLEVDNETLKQEFKNSLILSLFSLLIPGVGGYLIGQYLGLGFIGSLLYAVI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
FASHSVAIVYAILEELKMVKTRLGTIILSATIIVDLFTLLLLSVVIKLGIGGENVGTFLL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ETVLYIGVLLLAIPSLSKNILGVFEKLHAQRIHYVLFIIFIAIIVGEVIGIHPIVGAFIC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVAVSEALTKEEHDELLNKNLNAIGYGFFIPIFFLVLGMETNIRVIFNLSNLELLLITLI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
SAVALKFISGFIALRILGFDRIKNTIGGLLTVPKISASLVAASIGRELGLIGNEIFVTIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCHHHHHHHHH
ALSVITATITPIVVKHIFVAKCNKKAKN
HHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087