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The map label for this gene is hisG

Identifier: 15669390

GI number: 15669390

Start: 1147477

End: 1148343

Strand: Reverse

Name: hisG

Synonym: MJ1204

Alternate gene names: 15669390

Gene position: 1148343-1147477 (Counterclockwise)

Preceding gene: 15669391

Following gene: 15669389

Centisome position: 68.97

GC content: 32.76

Gene sequence:

>867_bases
ATGATAATGTTTGCATTACCAAATAAAGGGAGGATTTCAGAGCCAGTAATGAAAGTTTTAGAGAAGGCAGGATTAAAGAT
TACAGTTAAGGGAAGAAGTTTATTTGCTAACACTGTAGATGACAACATCAAAGTAATGTTTGCAAGAGCAAGAGATATTC
CGGAGTTTGTGGCTGATGGTGTTGCAGATATAGGAGTAACTGGCTATGATTTAGTTTTAGAGAGAAATGTTGAAGATAAA
GTTGATTTCCTATTAGATTTTGGTTTTGGATTTGCAAAACTGGTTTTAGCCGCTCCAGAGAGCTCAAATATAAACAGCAT
AGACGATATAAAAGAAGGGATGAGAGTAGCAACAGAATTCCCAAACCTAACAAAAAAATACTTTGAAAAATTAAATAAGA
AAGTTGAGATTATTGAACTTAGTGGAGCAACAGAGATAGCTCCATTCATAGGAATAGCTGATTTAATTAGTGATTTAACA
TCTACAGGAACAACTTTAAGGTTGAATAGGTTAAAAGTTATAGATGAAATTGTCTCATCAACTACAAGATTAATAGCAAA
CAAAAACAGCTTAAAAGATAAAGAGAAAAGAGAAAAAATAAATCAAATAGTTATTGCCATAAAAAGTGTTTTATTTGCTG
AAACAAAAAGATTAATTATGATGAATGCCCCAAAGGATAAAGTCGAAGAGATTAGAAAATTAATTCCAGGAATGGCTGGT
CCAACAGTTTCTAAGGTTTTATCTGACGATAATATGGTAGCTATTCATGCCGTTGTTAATGAGGATGAGATATTTACCTT
AGTTCCTAAGCTTCATGCTTTAGGAGCGAGAGATATATTGGTGGTGCCTATTGAGAGGATTTTATAA

Upstream 100 bases:

>100_bases
CTTACTTAGAGTCAGTGGAGAAAAAATAAAAAAAGAAATTCAACGAAAGAGATGCAAAATAAAAAATACAAATACATGAA
TATAATAATTACGTGAGAAG

Downstream 100 bases:

>100_bases
ACTTACCCAAAAGTTTTATATACTAAAAGTCAATATGTTGTTATACCTATTCTAAGCCACGATGATAACTACAGGGCTTT
TGCAGGAAAATATTTCTTAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MIMFALPNKGRISEPVMKVLEKAGLKITVKGRSLFANTVDDNIKVMFARARDIPEFVADGVADIGVTGYDLVLERNVEDK
VDFLLDFGFGFAKLVLAAPESSNINSIDDIKEGMRVATEFPNLTKKYFEKLNKKVEIIELSGATEIAPFIGIADLISDLT
STGTTLRLNRLKVIDEIVSSTTRLIANKNSLKDKEKREKINQIVIAIKSVLFAETKRLIMMNAPKDKVEEIRKLIPGMAG
PTVSKVLSDDNMVAIHAVVNEDEIFTLVPKLHALGARDILVVPIERIL

Sequences:

>Translated_288_residues
MIMFALPNKGRISEPVMKVLEKAGLKITVKGRSLFANTVDDNIKVMFARARDIPEFVADGVADIGVTGYDLVLERNVEDK
VDFLLDFGFGFAKLVLAAPESSNINSIDDIKEGMRVATEFPNLTKKYFEKLNKKVEIIELSGATEIAPFIGIADLISDLT
STGTTLRLNRLKVIDEIVSSTTRLIANKNSLKDKEKREKINQIVIAIKSVLFAETKRLIMMNAPKDKVEEIRKLIPGMAG
PTVSKVLSDDNMVAIHAVVNEDEIFTLVPKLHALGARDILVVPIERIL
>Mature_288_residues
MIMFALPNKGRISEPVMKVLEKAGLKITVKGRSLFANTVDDNIKVMFARARDIPEFVADGVADIGVTGYDLVLERNVEDK
VDFLLDFGFGFAKLVLAAPESSNINSIDDIKEGMRVATEFPNLTKKYFEKLNKKVEIIELSGATEIAPFIGIADLISDLT
STGTTLRLNRLKVIDEIVSSTTRLIANKNSLKDKEKREKINQIVIAIKSVLFAETKRLIMMNAPKDKVEEIRKLIPGMAG
PTVSKVLSDDNMVAIHAVVNEDEIFTLVPKLHALGARDILVVPIERIL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=33.7883959044369, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320896, Length=291, Percent_Identity=32.3024054982818, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_METJA (Q58601)

Other databases:

- EMBL:   L77117
- PIR:   C64450
- RefSeq:   NP_248199.1
- ProteinModelPortal:   Q58601
- SMR:   Q58601
- GeneID:   1452099
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1204
- NMPDR:   fig|243232.1.peg.1236
- TIGR:   MJ1204
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   MJAN243232:MJ_1204-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31861; Mature: 31861

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMFALPNKGRISEPVMKVLEKAGLKITVKGRSLFANTVDDNIKVMFARARDIPEFVADG
CEEEECCCCCCCHHHHHHHHHHCCCEEEEECCEEEECCCCCCEEEEEEHHCCCHHHHHCC
VADIGVTGYDLVLERNVEDKVDFLLDFGFGFAKLVLAAPESSNINSIDDIKEGMRVATEF
HHHCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHC
PNLTKKYFEKLNKKVEIIELSGATEIAPFIGIADLISDLTSTGTTLRLNRLKVIDEIVSS
CHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
TTRLIANKNSLKDKEKREKINQIVIAIKSVLFAETKRLIMMNAPKDKVEEIRKLIPGMAG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCC
PTVSKVLSDDNMVAIHAVVNEDEIFTLVPKLHALGARDILVVPIERIL
CHHHHHHCCCCEEEEEEEECCCCCEEHHHHHHHCCCCCEEEECHHHHC
>Mature Secondary Structure
MIMFALPNKGRISEPVMKVLEKAGLKITVKGRSLFANTVDDNIKVMFARARDIPEFVADG
CEEEECCCCCCCHHHHHHHHHHCCCEEEEECCEEEECCCCCCEEEEEEHHCCCHHHHHCC
VADIGVTGYDLVLERNVEDKVDFLLDFGFGFAKLVLAAPESSNINSIDDIKEGMRVATEF
HHHCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHC
PNLTKKYFEKLNKKVEIIELSGATEIAPFIGIADLISDLTSTGTTLRLNRLKVIDEIVSS
CHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
TTRLIANKNSLKDKEKREKINQIVIAIKSVLFAETKRLIMMNAPKDKVEEIRKLIPGMAG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCC
PTVSKVLSDDNMVAIHAVVNEDEIFTLVPKLHALGARDILVVPIERIL
CHHHHHHCCCCEEEEEEEECCCCCEEHHHHHHHCCCCCEEEECHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087