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The map label for this gene is dut [H]

Identifier: 15669290

GI number: 15669290

Start: 1043229

End: 1043714

Strand: Direct

Name: dut [H]

Synonym: MJ1102

Alternate gene names: 15669290

Gene position: 1043229-1043714 (Clockwise)

Preceding gene: 15669289

Following gene: 15669297

Centisome position: 62.66

GC content: 33.13

Gene sequence:

>486_bases
ATGGTGGTGAAATTAATGATTATAGGAGCTAATACATCAAAAAACTTTTTTGATAATTTAGAAGAGGAGCAGATTCAACA
ATGTGGGATAGATTTGAGAGTTTGGAAGATATTTAAAATAGAGGGAGAAGGGGTTATTGATTTCTCAAATGAGAAAAGAA
AGCTACCAAACTACATAGAGATATTCAACTCTGAAAAAGATGAACACATAAAATTAGATAGAGGAGTTTATATTGTAAAG
GTAGCTGATTATATAAAAATCCCAGAAAATGTAGCTGGCTTTGCATATCCAAGGAGTTCTCTGCTAAGAATGGGGGCAAC
TTTATACTCTGCAGTTCACGACCCTGGCTATGAAGGAAGACCAGAATATTTAATGCAAGTTTTTAATCCAATAACCATCT
ACAAATATGCAAGAATTGCCCAGATTGTTTTTGTTGAGTGTAGAGATGTTAAAGGAGTTTATGAAGGAATTTATAAAGGG
AGATAA

Upstream 100 bases:

>100_bases
AGAGTGTTATGCCCTATATTGGTATATCTCCAAGAGACATTAAAAGGGGCTGTAAGCCCCTTCTTAATGTATCCCGGGTA
TACCAATAGGGCAGAGCCCT

Downstream 100 bases:

>100_bases
GATAAAATTATGGGAAATAATCATATATGCTTTTTCTATGCAATACTCTTCTAAAAATAATCGTATCTCCATTAACCTCA
ATACCTATTCTATAATTTCC

Product: deoxycytidine triphosphate deaminase

Products: NA

Alternate protein names: dUTPase; MjDUT; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MVVKLMIIGANTSKNFFDNLEEEQIQQCGIDLRVWKIFKIEGEGVIDFSNEKRKLPNYIEIFNSEKDEHIKLDRGVYIVK
VADYIKIPENVAGFAYPRSSLLRMGATLYSAVHDPGYEGRPEYLMQVFNPITIYKYARIAQIVFVECRDVKGVYEGIYKG
R

Sequences:

>Translated_161_residues
MVVKLMIIGANTSKNFFDNLEEEQIQQCGIDLRVWKIFKIEGEGVIDFSNEKRKLPNYIEIFNSEKDEHIKLDRGVYIVK
VADYIKIPENVAGFAYPRSSLLRMGATLYSAVHDPGYEGRPEYLMQVFNPITIYKYARIAQIVFVECRDVKGVYEGIYKG
R
>Mature_161_residues
MVVKLMIIGANTSKNFFDNLEEEQIQQCGIDLRVWKIFKIEGEGVIDFSNEKRKLPNYIEIFNSEKDEHIKLDRGVYIVK
VADYIKIPENVAGFAYPRSSLLRMGATLYSAVHDPGYEGRPEYLMQVFNPITIYKYARIAQIVFVECRDVKGVYEGIYKG
R

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0717

COG function: function code F; Deoxycytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 18641; Mature: 18641

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKLMIIGANTSKNFFDNLEEEQIQQCGIDLRVWKIFKIEGEGVIDFSNEKRKLPNYIE
CEEEEEEEECCCCCHHHHCCCHHHHHHCCCCEEEEEEEEECCCEEEEECCCCCCCCHHHH
IFNSEKDEHIKLDRGVYIVKVADYIKIPENVAGFAYPRSSLLRMGATLYSAVHDPGYEGR
HHCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
PEYLMQVFNPITIYKYARIAQIVFVECRDVKGVYEGIYKGR
HHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHHHHHHHCCC
>Mature Secondary Structure
MVVKLMIIGANTSKNFFDNLEEEQIQQCGIDLRVWKIFKIEGEGVIDFSNEKRKLPNYIE
CEEEEEEEECCCCCHHHHCCCHHHHHHCCCCEEEEEEEEECCCEEEEECCCCCCCCHHHH
IFNSEKDEHIKLDRGVYIVKVADYIKIPENVAGFAYPRSSLLRMGATLYSAVHDPGYEGR
HHCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
PEYLMQVFNPITIYKYARIAQIVFVECRDVKGVYEGIYKGR
HHHHHHHHCCHHHHHHHHHHHHHEEECCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 12538648 [H]