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The map label for this gene is rio2

Identifier: 15669261

GI number: 15669261

Start: 1012874

End: 1013686

Strand: Reverse

Name: rio2

Synonym: MJ1073

Alternate gene names: 15669261

Gene position: 1013686-1012874 (Counterclockwise)

Preceding gene: 15669262

Following gene: 15669260

Centisome position: 60.88

GC content: 33.83

Gene sequence:

>813_bases
ATGAGACATCATGAGTGGGTGCCGTTAGATGAGATTGTTAGAAAGGCGAAGATGCCAGAAAAGGACGTGCTTTACAGATT
AAAGAGGTTGAACAAATTTGGATTTGTTGTGAGGAGCACTTATGGTTATGCTGTCTCAATGGGAGGCTATGATGCCCTTG
CAATAAATGCTTTTGTTAAAAAAGGTATCTTAAAAGCCATAGGTAATAAGTTGGGAGTTGGTAAGGAGGGGGATGTTTAT
ACTGTCTTGCTGAGTGATGGGAGAGAGGCGGTTTTAAAATTTCATAAACATGGAAGAACTTGCTTTACAAGAGGAAAGAG
GTATAGAGGATATTTGGCTGATAAACATCATATAAGTTGGCTCTATGTTTCAAGATTAACAGCTGAGAGAGAGTTTGAGA
TTTTAAATGAGTTATTTCCAATAGTTAAAGTCCCTGAACCAATAGAATGGAATAGACATGCAATTATTATGGGTAAAGTT
GTTGGAGAAGAGTTAAAGAGATTAGATTTATCAGAATTTATGAGTAAAGAGGAGATTAAAGATTTATTCTGGAAAATTAT
TGAAGAGGTTAAAAAGGCTTATGAAATTGGCTATATACATGGAGATTTGAGTGAATTTAATATTTTATTAGATGAAAATG
GGGATTTTGTTATTATTGACTGGCCTCAGGCAGTTCCTAAATACCATCCAGATGCTGAATTTTACTTAAAGAGGGACATT
TGGAACGTAATAAGATACTTTAAAAAGTATAAGATTGACAAAGAGGATGAGAAGATTGATGTTGATAAAATCTTTGAGTA
TATAACTAAATAA

Upstream 100 bases:

>100_bases
ATCCAATAAGGAGGGGATAATCATAATTAAAAAACTAATTGAAGCATTAAGACAGGCACAGGATGAAGATTTTAAAATAT
TAAAAATTATAGAGCTGTCA

Downstream 100 bases:

>100_bases
CGGTTTTGGTGAAATCATGAGTATCTATAATGAATTATATAAATTAATGCTTGAATAAGTTAAAGATAAAGAAAAAGCTA
AAAAATACTCCAAAATAATA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MRHHEWVPLDEIVRKAKMPEKDVLYRLKRLNKFGFVVRSTYGYAVSMGGYDALAINAFVKKGILKAIGNKLGVGKEGDVY
TVLLSDGREAVLKFHKHGRTCFTRGKRYRGYLADKHHISWLYVSRLTAEREFEILNELFPIVKVPEPIEWNRHAIIMGKV
VGEELKRLDLSEFMSKEEIKDLFWKIIEEVKKAYEIGYIHGDLSEFNILLDENGDFVIIDWPQAVPKYHPDAEFYLKRDI
WNVIRYFKKYKIDKEDEKIDVDKIFEYITK

Sequences:

>Translated_270_residues
MRHHEWVPLDEIVRKAKMPEKDVLYRLKRLNKFGFVVRSTYGYAVSMGGYDALAINAFVKKGILKAIGNKLGVGKEGDVY
TVLLSDGREAVLKFHKHGRTCFTRGKRYRGYLADKHHISWLYVSRLTAEREFEILNELFPIVKVPEPIEWNRHAIIMGKV
VGEELKRLDLSEFMSKEEIKDLFWKIIEEVKKAYEIGYIHGDLSEFNILLDENGDFVIIDWPQAVPKYHPDAEFYLKRDI
WNVIRYFKKYKIDKEDEKIDVDKIFEYITK
>Mature_270_residues
MRHHEWVPLDEIVRKAKMPEKDVLYRLKRLNKFGFVVRSTYGYAVSMGGYDALAINAFVKKGILKAIGNKLGVGKEGDVY
TVLLSDGREAVLKFHKHGRTCFTRGKRYRGYLADKHHISWLYVSRLTAEREFEILNELFPIVKVPEPIEWNRHAIIMGKV
VGEELKRLDLSEFMSKEEIKDLFWKIIEEVKKAYEIGYIHGDLSEFNILLDENGDFVIIDWPQAVPKYHPDAEFYLKRDI
WNVIRYFKKYKIDKEDEKIDVDKIFEYITK

Specific function: Unknown

COG id: COG0478

COG function: function code T; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain

Homologues:

Organism=Homo sapiens, GI229331967, Length=257, Percent_Identity=35.408560311284, Blast_Score=167, Evalue=7e-42,
Organism=Homo sapiens, GI229331971, Length=257, Percent_Identity=35.408560311284, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI23510356, Length=224, Percent_Identity=28.125, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32564178, Length=265, Percent_Identity=36.6037735849057, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17556977, Length=198, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324122, Length=261, Percent_Identity=32.183908045977, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24649986, Length=266, Percent_Identity=33.8345864661654, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24662811, Length=231, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356879, Length=231, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIO2_METJA (Q58473)

Other databases:

- EMBL:   L77117
- PIR:   H64433
- RefSeq:   NP_248066.1
- ProteinModelPortal:   Q58473
- SMR:   Q58473
- GeneID:   1451969
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1073
- NMPDR:   fig|243232.1.peg.1103
- TIGR:   MJ1073
- HOGENOM:   HBG746084
- OMA:   SWLYVSR
- ProtClustDB:   CLSK876440
- BioCyc:   MJAN243232:MJ_1073-MONOMER
- BRENDA:   2.7.11.1
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR015285
- InterPro:   IPR000687
- InterPro:   IPR018935
- SMART:   SM00090

Pfam domain/function: PF01163 RIO1; PF09202 Rio2_N; SSF56112 Kinase_like

EC number: =2.7.11.1

Molecular weight: Translated: 31881; Mature: 31881

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50011 PROTEIN_KINASE_DOM; PS01245 RIO1; PS00109 PROTEIN_KINASE_TYR

Important sites: ACT_SITE 202-202 BINDING 93-93 BINDING 220-220

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHHEWVPLDEIVRKAKMPEKDVLYRLKRLNKFGFVVRSTYGYAVSMGGYDALAINAFVK
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCEEEEECCCHHHHHHHHHH
KGILKAIGNKLGVGKEGDVYTVLLSDGREAVLKFHKHGRTCFTRGKRYRGYLADKHHISW
HHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCHHCCCCCCCCCCCE
LYVSRLTAEREFEILNELFPIVKVPEPIEWNRHAIIMGKVVGEELKRLDLSEFMSKEEIK
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHH
DLFWKIIEEVKKAYEIGYIHGDLSEFNILLDENGDFVIIDWPQAVPKYHPDAEFYLKRDI
HHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCEEEEECCHHCCCCCCCHHHHHHHHH
WNVIRYFKKYKIDKEDEKIDVDKIFEYITK
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRHHEWVPLDEIVRKAKMPEKDVLYRLKRLNKFGFVVRSTYGYAVSMGGYDALAINAFVK
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCEEEEECCCHHHHHHHHHH
KGILKAIGNKLGVGKEGDVYTVLLSDGREAVLKFHKHGRTCFTRGKRYRGYLADKHHISW
HHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCHHCCCCCCCCCCCE
LYVSRLTAEREFEILNELFPIVKVPEPIEWNRHAIIMGKVVGEELKRLDLSEFMSKEEIK
EHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHH
DLFWKIIEEVKKAYEIGYIHGDLSEFNILLDENGDFVIIDWPQAVPKYHPDAEFYLKRDI
HHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCEEEEECCHHCCCCCCCHHHHHHHHH
WNVIRYFKKYKIDKEDEKIDVDKIFEYITK
HHHHHHHHHCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087