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The map label for this gene is hisC

Identifier: 15669145

GI number: 15669145

Start: 886169

End: 887290

Strand: Direct

Name: hisC

Synonym: MJ0955

Alternate gene names: 15669145

Gene position: 886169-887290 (Clockwise)

Preceding gene: 15669143

Following gene: 15669146

Centisome position: 53.22

GC content: 31.19

Gene sequence:

>1122_bases
TTGGGTGATTGGATGATAGAAAATAAAGTAAGAGACGTTGTTAAAAAATTAAAGCCCTATGTTCCAGGAAAATCAAAAGA
AGAGATAGCAAGGGCTTACGGAATAAAACCAGAGGACATTATAAAACTTGGTTCTAATGAAAATCCTTGGGGACCATCTC
CAAAAATAAAAGAAAAAATTTTAGATGAAATTGACAAAATTCACCAATATCCAGAGCCAGTAAATCCAATTTTAATGAAA
GAGTTAAGCAAATTTTTGAATGTTGATGAGGAAAACATAATTGTTGGAGGAGATGGAGCTGATGAGATTATAGACACAAT
ATTTAGAACGTTTGTTGATGATGGAGATGAGGTTATAATTCCAATTCCAACATTTACCCAATATAGAGTTTCAGCAACAA
TCCACAATGCTAAAATAAAATATGCTAAATATGATAAGGAGAAAGACTTTAAATTGAATGTTGAAAGTGTCTTAAATAAT
ATAACAGATAAAACGAAGGTTATTTTCCTCTGCACTCCAAATAATCCAACAGGAAATATAATAGAAAATAGAGATGTAGA
GAGGGTTATCAATGAAACAGACGCTTTAGTTGTTATTGACCATGCATACATTGAGTATGCTAAAAAAGAATATGATTGGA
CTCAAAAAGCCCCTGAATATGATAATGTTATTGTTTTAAGAACCTTTTCAAAGGTCTTTGGTTTAGCAGGAATGAGGGTT
GGTTATGGTGTTGCAAATAAAAAAATCATAGATTATATGATGAGAGTTAAGCCAATATTTAGCTTAACAAGGTTAAGTCA
AGTTTGTGCCATAACTGCATTAAGAGATAGAGAATTCTTTGAAAGATGTGTTAGAGATGGAATTAAAAGTAGAGAGATGC
TCTACAATGGATTGAAGAAGTTTAAGGATATTAAAGTTTATCCTTCAGAAGCTAATTATCTATTGGTTGAATTAAAAACA
ATGAAAGCAAAAGAATTTTGTGAGGAACTATTAAAAAGAGGTGTTATTGTTAGAGATTGCACATCCTTTGATGGTTTAGG
GGATAATTATGTTAGAGTATCAATAGGGACGTTTGAAGAGGTTGAAAGGTTTTTAAAGATTTTGGAGGAGATTATAAGCT
AA

Upstream 100 bases:

>100_bases
GTAAAAGTGTCCTCTTCACAATTAACCCCTCCATCATTTGTAATCTTAACAATAATAAAAAATCCAGAAATCTTATTTAA
AATATTTTTGGTTAAAAATT

Downstream 100 bases:

>100_bases
ATCTTTTTAATTTTTGTTTTATTATTTTATTTTTATTAATTTATCCATTTAAATTAAAGAATAATAAAAACTTTTATATG
TAAGTCTTTTGATAATTAAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MGDWMIENKVRDVVKKLKPYVPGKSKEEIARAYGIKPEDIIKLGSNENPWGPSPKIKEKILDEIDKIHQYPEPVNPILMK
ELSKFLNVDEENIIVGGDGADEIIDTIFRTFVDDGDEVIIPIPTFTQYRVSATIHNAKIKYAKYDKEKDFKLNVESVLNN
ITDKTKVIFLCTPNNPTGNIIENRDVERVINETDALVVIDHAYIEYAKKEYDWTQKAPEYDNVIVLRTFSKVFGLAGMRV
GYGVANKKIIDYMMRVKPIFSLTRLSQVCAITALRDREFFERCVRDGIKSREMLYNGLKKFKDIKVYPSEANYLLVELKT
MKAKEFCEELLKRGVIVRDCTSFDGLGDNYVRVSIGTFEEVERFLKILEEIIS

Sequences:

>Translated_373_residues
MGDWMIENKVRDVVKKLKPYVPGKSKEEIARAYGIKPEDIIKLGSNENPWGPSPKIKEKILDEIDKIHQYPEPVNPILMK
ELSKFLNVDEENIIVGGDGADEIIDTIFRTFVDDGDEVIIPIPTFTQYRVSATIHNAKIKYAKYDKEKDFKLNVESVLNN
ITDKTKVIFLCTPNNPTGNIIENRDVERVINETDALVVIDHAYIEYAKKEYDWTQKAPEYDNVIVLRTFSKVFGLAGMRV
GYGVANKKIIDYMMRVKPIFSLTRLSQVCAITALRDREFFERCVRDGIKSREMLYNGLKKFKDIKVYPSEANYLLVELKT
MKAKEFCEELLKRGVIVRDCTSFDGLGDNYVRVSIGTFEEVERFLKILEEIIS
>Mature_372_residues
GDWMIENKVRDVVKKLKPYVPGKSKEEIARAYGIKPEDIIKLGSNENPWGPSPKIKEKILDEIDKIHQYPEPVNPILMKE
LSKFLNVDEENIIVGGDGADEIIDTIFRTFVDDGDEVIIPIPTFTQYRVSATIHNAKIKYAKYDKEKDFKLNVESVLNNI
TDKTKVIFLCTPNNPTGNIIENRDVERVINETDALVVIDHAYIEYAKKEYDWTQKAPEYDNVIVLRTFSKVFGLAGMRVG
YGVANKKIIDYMMRVKPIFSLTRLSQVCAITALRDREFFERCVRDGIKSREMLYNGLKKFKDIKVYPSEANYLLVELKTM
KAKEFCEELLKRGVIVRDCTSFDGLGDNYVRVSIGTFEEVERFLKILEEIIS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=382, Percent_Identity=29.3193717277487, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788722, Length=377, Percent_Identity=27.3209549071618, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786816, Length=257, Percent_Identity=22.1789883268482, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788627, Length=300, Percent_Identity=20.6666666666667, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=27.3972602739726, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METJA (Q58365)

Other databases:

- EMBL:   L77117
- PIR:   C64419
- RefSeq:   NP_247950.1
- ProteinModelPortal:   Q58365
- GeneID:   1451853
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0955
- NMPDR:   fig|243232.1.peg.987
- TIGR:   MJ0955
- HOGENOM:   HBG646350
- OMA:   NADENRR
- ProtClustDB:   PRK00950
- BioCyc:   MJAN243232:MJ_0955-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42962; Mature: 42831

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDWMIENKVRDVVKKLKPYVPGKSKEEIARAYGIKPEDIIKLGSNENPWGPSPKIKEKI
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCHHHHHH
LDEIDKIHQYPEPVNPILMKELSKFLNVDEENIIVGGDGADEIIDTIFRTFVDDGDEVII
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEE
PIPTFTQYRVSATIHNAKIKYAKYDKEKDFKLNVESVLNNITDKTKVIFLCTPNNPTGNI
ECCCCCCEEEEEEEECCEEEEEECCCCCCCEEEHHHHHHCCCCCEEEEEEECCCCCCCCC
IENRDVERVINETDALVVIDHAYIEYAKKEYDWTQKAPEYDNVIVLRTFSKVFGLAGMRV
CCCCCHHHHHCCCCCEEEEEHHHHHHHHHHCCHHHCCCCCCCEEEEEHHHHHHHHCCHHH
GYGVANKKIIDYMMRVKPIFSLTRLSQVCAITALRDREFFERCVRDGIKSREMLYNGLKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FKDIKVYPSEANYLLVELKTMKAKEFCEELLKRGVIVRDCTSFDGLGDNYVRVSIGTFEE
HHCCEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCHHH
VERFLKILEEIIS
HHHHHHHHHHHHC
>Mature Secondary Structure 
GDWMIENKVRDVVKKLKPYVPGKSKEEIARAYGIKPEDIIKLGSNENPWGPSPKIKEKI
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHEECCCCCCCCCCCHHHHHH
LDEIDKIHQYPEPVNPILMKELSKFLNVDEENIIVGGDGADEIIDTIFRTFVDDGDEVII
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEE
PIPTFTQYRVSATIHNAKIKYAKYDKEKDFKLNVESVLNNITDKTKVIFLCTPNNPTGNI
ECCCCCCEEEEEEEECCEEEEEECCCCCCCEEEHHHHHHCCCCCEEEEEEECCCCCCCCC
IENRDVERVINETDALVVIDHAYIEYAKKEYDWTQKAPEYDNVIVLRTFSKVFGLAGMRV
CCCCCHHHHHCCCCCEEEEEHHHHHHHHHHCCHHHCCCCCCCEEEEEHHHHHHHHCCHHH
GYGVANKKIIDYMMRVKPIFSLTRLSQVCAITALRDREFFERCVRDGIKSREMLYNGLKK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
FKDIKVYPSEANYLLVELKTMKAKEFCEELLKRGVIVRDCTSFDGLGDNYVRVSIGTFEE
HHCCEEECCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCHHH
VERFLKILEEIIS
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087