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The map label for this gene is pnk

Identifier: 15669107

GI number: 15669107

Start: 847949

End: 849673

Strand: Direct

Name: pnk

Synonym: MJ0917

Alternate gene names: 15669107

Gene position: 847949-849673 (Clockwise)

Preceding gene: 15669102

Following gene: 15669113

Centisome position: 50.93

GC content: 31.36

Gene sequence:

>1725_bases
GTGGTAATTATGGAAGGATTCAAAATTGCAATGAAGGTTATTGATGAGATTGATAAAAAGATAAAACCTTTAATTGGCTG
GGAAAAAGCAGATGAAGTGGTTAAAATAGGTGCAGATGGGACTCCAACGAAAAGAATTGATGTAATTGCTGAAAATATGG
CAATAAATATTTTAGAGAAGTTTAGTGGAGGGATTTTAATAAGTGAAGAAATTGGATTGAAAGTTGTTGGCGATGAGTTA
GAGTATATTTTTATCTTGGACCCCATAGATGGAACATACAACGCTTTAAAATCTATCCCCATATATTCAACTTCAATAGC
TGTAGCAAAAATTAAAGGGGAGGATAAAAAACTAATTAGAGAAAATATTAATAACATAGATTGGATTAAAAGTTTTATAG
CTAATAAATATACAATAAATGATTTATATGTTGGAATTGTGAAAAATTTAGCTACTGGAGATTTGTATTATGCTATCAAA
GGAGAAGGAAGCTTTTTAGAGAAAGATGGGGAAAAAATTAAAATAGAAACAAAAAATATAAAAGATTTAAAAGAAGCATC
TGTTGGATTGTTTGTTTATGGGTTATCTAATGATTTGTTAGAATTTTTAAAGGAAAGGAAGGTTAGGAGGGTCAGATTAT
TTGGTTCTATGGCTTTGGAGATGTGTTATGTTGTTAGTGGGGCTTTAGACGCTTATATAAACGTAAATGAAAATTCTCGT
CTCTGCGATATAGCTGGGGCTTATGTTATCTGCAGAGAGGGAAATGCAATTGTAACAAACAAAAATGGGAAACCATTAAA
TATGAAATTACATTTAATGGAGAGAACATCTTTAATTGTTAGCAATAAATATTTACATAAAAAGCTTATAGCTTTATTTG
GCAACAGATGGATAATAAAGCCAGTGAAATTTGGAATAGTTGTTAGGGAGGATAAGGAAGAGGCAATTAACTTGGCTATA
GAGATTTGTAAATATCTAAAAGATAAAAACATCCCCTTCTGCGTTGAGGACTTTTTAAGAGAGAGAGTTGGTGGCGATAA
GTTTGATATTTCAGCAATCTCTCATATTATTGCTATTGGTGGGGATGGAACAATACTTAGGGCTTCAAGATTGGTTAATG
GAGAGACAATACCTATAATAGCTGTAAATATGGGAAAAGTTGGATTTTTAGCTGAGTTTTGTAAAGATGAAGTTTTTGAA
ATAATTGATAAGGTAATATATGGAGAGTATGAGATAGAAAAAAGAAGTAAATTATCTTGCAAAATAATAAAAGATAATAG
AGTTATAAAAACACCCTCTGCCTTAAATGAGATGGTTGTTATTACAAAAAACCCTGCAAAGATTTTAGAATTTGATGTAT
ATGTTAATGATACGCTTGTTGAAAATGTTAGGGCGGATGGAATAATTGTCTCAACACCAACTGGTTCAACAGCCTATTCT
CTAAGTGCTGGAGGGCCTATCGTTGAACCAAACGTTGATTGCTTTATAATATCACCAATATGTCCATTTAAGTTATCTTC
GAGACCTTTAGTGATTTCCGCGTCAAATAGAATTAAACTAAAGCTTAAATTGGAAAAACCTGCTTTATTGGTTATTGATG
GAAGTGTTGAATATGAAATAAATAAAGATGATGAGTTAATCTTTGAAAAATCCGACAGCTATGCTTATTTTGTAAAGGGG
CAGAGTTTTTATAATAAGTTGAGCAGATGCCTTGGAATTAAATAA

Upstream 100 bases:

>100_bases
AAAATATCACTAACTCTAATTGCCATTGCTATCCCCCTAATTTTTATACTCCTTTAACTTAAAAAATTACTATTTATTTA
TGTTTATTTAAATCTTTTGT

Downstream 100 bases:

>100_bases
ATTACTTTATCACGAACTCCCTAACTTTCTCTCTTATATTTTCACTCTCCATTATTGATGAGCCAATTAAAGCAGCGTCA
GTGAATTTTAAAACATAATT

Product: inorganic polyphosphate/ATP-NAD kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MVIMEGFKIAMKVIDEIDKKIKPLIGWEKADEVVKIGADGTPTKRIDVIAENMAINILEKFSGGILISEEIGLKVVGDEL
EYIFILDPIDGTYNALKSIPIYSTSIAVAKIKGEDKKLIRENINNIDWIKSFIANKYTINDLYVGIVKNLATGDLYYAIK
GEGSFLEKDGEKIKIETKNIKDLKEASVGLFVYGLSNDLLEFLKERKVRRVRLFGSMALEMCYVVSGALDAYINVNENSR
LCDIAGAYVICREGNAIVTNKNGKPLNMKLHLMERTSLIVSNKYLHKKLIALFGNRWIIKPVKFGIVVREDKEEAINLAI
EICKYLKDKNIPFCVEDFLRERVGGDKFDISAISHIIAIGGDGTILRASRLVNGETIPIIAVNMGKVGFLAEFCKDEVFE
IIDKVIYGEYEIEKRSKLSCKIIKDNRVIKTPSALNEMVVITKNPAKILEFDVYVNDTLVENVRADGIIVSTPTGSTAYS
LSAGGPIVEPNVDCFIISPICPFKLSSRPLVISASNRIKLKLKLEKPALLVIDGSVEYEINKDDELIFEKSDSYAYFVKG
QSFYNKLSRCLGIK

Sequences:

>Translated_574_residues
MVIMEGFKIAMKVIDEIDKKIKPLIGWEKADEVVKIGADGTPTKRIDVIAENMAINILEKFSGGILISEEIGLKVVGDEL
EYIFILDPIDGTYNALKSIPIYSTSIAVAKIKGEDKKLIRENINNIDWIKSFIANKYTINDLYVGIVKNLATGDLYYAIK
GEGSFLEKDGEKIKIETKNIKDLKEASVGLFVYGLSNDLLEFLKERKVRRVRLFGSMALEMCYVVSGALDAYINVNENSR
LCDIAGAYVICREGNAIVTNKNGKPLNMKLHLMERTSLIVSNKYLHKKLIALFGNRWIIKPVKFGIVVREDKEEAINLAI
EICKYLKDKNIPFCVEDFLRERVGGDKFDISAISHIIAIGGDGTILRASRLVNGETIPIIAVNMGKVGFLAEFCKDEVFE
IIDKVIYGEYEIEKRSKLSCKIIKDNRVIKTPSALNEMVVITKNPAKILEFDVYVNDTLVENVRADGIIVSTPTGSTAYS
LSAGGPIVEPNVDCFIISPICPFKLSSRPLVISASNRIKLKLKLEKPALLVIDGSVEYEINKDDELIFEKSDSYAYFVKG
QSFYNKLSRCLGIK
>Mature_574_residues
MVIMEGFKIAMKVIDEIDKKIKPLIGWEKADEVVKIGADGTPTKRIDVIAENMAINILEKFSGGILISEEIGLKVVGDEL
EYIFILDPIDGTYNALKSIPIYSTSIAVAKIKGEDKKLIRENINNIDWIKSFIANKYTINDLYVGIVKNLATGDLYYAIK
GEGSFLEKDGEKIKIETKNIKDLKEASVGLFVYGLSNDLLEFLKERKVRRVRLFGSMALEMCYVVSGALDAYINVNENSR
LCDIAGAYVICREGNAIVTNKNGKPLNMKLHLMERTSLIVSNKYLHKKLIALFGNRWIIKPVKFGIVVREDKEEAINLAI
EICKYLKDKNIPFCVEDFLRERVGGDKFDISAISHIIAIGGDGTILRASRLVNGETIPIIAVNMGKVGFLAEFCKDEVFE
IIDKVIYGEYEIEKRSKLSCKIIKDNRVIKTPSALNEMVVITKNPAKILEFDVYVNDTLVENVRADGIIVSTPTGSTAYS
LSAGGPIVEPNVDCFIISPICPFKLSSRPLVISASNRIKLKLKLEKPALLVIDGSVEYEINKDDELIFEKSDSYAYFVKG
QSFYNKLSRCLGIK

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=231, Percent_Identity=36.7965367965368, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1788968, Length=219, Percent_Identity=35.1598173515982, Blast_Score=148, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6320794, Length=214, Percent_Identity=34.1121495327103, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322509, Length=276, Percent_Identity=31.8840579710145, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6325068, Length=201, Percent_Identity=35.8208955223881, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28573828, Length=215, Percent_Identity=34.4186046511628, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573830, Length=215, Percent_Identity=34.4186046511628, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28573826, Length=215, Percent_Identity=34.4186046511628, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161077047, Length=215, Percent_Identity=34.4186046511628, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28573832, Length=215, Percent_Identity=34.4186046511628, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24653422, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129957, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653424, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363323, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281363321, Length=240, Percent_Identity=30.8333333333333, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_METJA (Q58327)

Other databases:

- EMBL:   L77117
- PIR:   E64414
- RefSeq:   NP_247912.1
- ProteinModelPortal:   Q58327
- SMR:   Q58327
- GeneID:   1451806
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0917
- NMPDR:   fig|243232.1.peg.949
- TIGR:   MJ0917
- HOGENOM:   HBG539147
- OMA:   PLIGWEK
- ProtClustDB:   PRK14076
- BioCyc:   MJAN243232:MJ_0917-MONOMER
- BRENDA:   2.7.1.23
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR021175
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275
- PIRSF:   PIRSF036641
- PRINTS:   PR00377

Pfam domain/function: PF00459 Inositol_P; PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 64120; Mature: 64120

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIMEGFKIAMKVIDEIDKKIKPLIGWEKADEVVKIGADGTPTKRIDVIAENMAINILEK
CEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHH
FSGGILISEEIGLKVVGDELEYIFILDPIDGTYNALKSIPIYSTSIAVAKIKGEDKKLIR
CCCCEEEEECCCEEEECCCEEEEEEECCCCCHHHHHHCCCEEECEEEEEEECCCHHHHHH
ENINNIDWIKSFIANKYTINDLYVGIVKNLATGDLYYAIKGEGSFLEKDGEKIKIETKNI
HCCCCHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCEEEEEECCC
KDLKEASVGLFVYGLSNDLLEFLKERKVRRVRLFGSMALEMCYVVSGALDAYINVNENSR
HHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
LCDIAGAYVICREGNAIVTNKNGKPLNMKLHLMERTSLIVSNKYLHKKLIALFGNRWIIK
EEEECCEEEEEECCCEEEECCCCCEEEEEEEEEECCEEEEECHHHHHHHHHHHCCCEEEE
PVKFGIVVREDKEEAINLAIEICKYLKDKNIPFCVEDFLRERVGGDKFDISAISHIIAIG
EEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEHHHHEEEEEEC
GDGTILRASRLVNGETIPIIAVNMGKVGFLAEFCKDEVFEIIDKVIYGEYEIEKRSKLSC
CCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEE
KIIKDNRVIKTPSALNEMVVITKNPAKILEFDVYVNDTLVENVRADGIIVSTPTGSTAYS
EEEECCEEEECCCCCCCEEEEECCCCEEEEEEEEECCHHHHCCCCCCEEEECCCCCCEEE
LSAGGPIVEPNVDCFIISPICPFKLSSRPLVISASNRIKLKLKLEKPALLVIDGSVEYEI
ECCCCCEECCCCCEEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCEEEEEECCEEEEE
NKDDELIFEKSDSYAYFVKGQSFYNKLSRCLGIK
CCCCCEEEECCCCEEEEEECHHHHHHHHHHHCCC
>Mature Secondary Structure
MVIMEGFKIAMKVIDEIDKKIKPLIGWEKADEVVKIGADGTPTKRIDVIAENMAINILEK
CEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEEEHHHHHHHHHH
FSGGILISEEIGLKVVGDELEYIFILDPIDGTYNALKSIPIYSTSIAVAKIKGEDKKLIR
CCCCEEEEECCCEEEECCCEEEEEEECCCCCHHHHHHCCCEEECEEEEEEECCCHHHHHH
ENINNIDWIKSFIANKYTINDLYVGIVKNLATGDLYYAIKGEGSFLEKDGEKIKIETKNI
HCCCCHHHHHHHHCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCEEEEEECCC
KDLKEASVGLFVYGLSNDLLEFLKERKVRRVRLFGSMALEMCYVVSGALDAYINVNENSR
HHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
LCDIAGAYVICREGNAIVTNKNGKPLNMKLHLMERTSLIVSNKYLHKKLIALFGNRWIIK
EEEECCEEEEEECCCEEEECCCCCEEEEEEEEEECCEEEEECHHHHHHHHHHHCCCEEEE
PVKFGIVVREDKEEAINLAIEICKYLKDKNIPFCVEDFLRERVGGDKFDISAISHIIAIG
EEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEHHHHEEEEEEC
GDGTILRASRLVNGETIPIIAVNMGKVGFLAEFCKDEVFEIIDKVIYGEYEIEKRSKLSC
CCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEE
KIIKDNRVIKTPSALNEMVVITKNPAKILEFDVYVNDTLVENVRADGIIVSTPTGSTAYS
EEEECCEEEECCCCCCCEEEEECCCCEEEEEEEEECCHHHHCCCCCCEEEECCCCCCEEE
LSAGGPIVEPNVDCFIISPICPFKLSSRPLVISASNRIKLKLKLEKPALLVIDGSVEYEI
ECCCCCEECCCCCEEEECCCCCCCCCCCCEEEECCCEEEEEEEECCCEEEEEECCEEEEE
NKDDELIFEKSDSYAYFVKGQSFYNKLSRCLGIK
CCCCCEEEECCCCEEEEEECHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087