Click here to switch to the map view.

The map label for this gene is 15668938

Identifier: 15668938

GI number: 15668938

Start: 681420

End: 682202

Strand: Reverse

Name: 15668938

Synonym: MJ0757

Alternate gene names: NA

Gene position: 682202-681420 (Counterclockwise)

Preceding gene: 15668939

Following gene: 15668937

Centisome position: 40.97

GC content: 33.08

Gene sequence:

>783_bases
TTGGTATTAAACATCAATTCTTTTTATAAAAATTGTAGGGGAGAGTTTATGAGGGCAGTTTTTATTTACCACAAAAATAA
TCAAAGAATGGAGAAATTCTATAAAAACCTTTTGAATGAACCAGATTTTTGTAGAATTTGTGATGATTGTTACAATTGCA
GAGGAAACTGGACTTTTAAGAATAATGTGAAAAATATCGTTATTGAGGAAGTTTATGAGGAGTTTGTTGATAACCCTTAC
GATTACCTTCCAGAACTCCCAGAGGGGGATATTTGTATAGCTCAACTACATGAAGATTTGTTGTATGAACTTCCTCTACT
GTTAAAAGAAAAGGGATATAAAGCTTTAATTGTTCCTTCTGAAACACCACATGATTTGTCTTTGGCATTGAGGAGAGATT
TAAAGAGAGTTTGCAGCAACTATAATATTGAGTTCGAAAACCCAAAACCCTTCTGTTCATTGGAGAAGAAAGAGGGTAAT
GAATATATAAATAAATTTATTGACTACTTTAAGATAGGAAAGCCAGAATTGGAGATAGAAGTTGAAAATGGCCTTATTAA
AGATGTTAAGGTTAAAATCTCTGCTCCCTGTGGGGAAACCTATTATATAGCCAAAAGATTGAAAGGAAAGGCTATAGATG
ATTTAAAGGAAGAGATTGCAAATGCCCACCACAACTATCCATGTTTAGCCAGTATGGAGATGGATAAAGAGTTAGGAGAC
ACTATTTTACATAAGGCTGGTTATATTGCATTTGAGGTAGTGGAAAAAGCCCTAAAAAAATAA

Upstream 100 bases:

>100_bases
AATTTATAGTGTGAGTAATAACTGCAGATTGATGCTATCAGATGTAGTTCCAGAAACTGAAGAAAAAGTGAAGTTAATAT
TTAAGAAAGTTTAAAAATTT

Downstream 100 bases:

>100_bases
ATTTTTTATTTTCATGGTTGTGCAATAATTTTCACAACTTAGTAAAATTTATATATTTGTTTTCTTACACTACTATATGT
AGTTAAAAAGATACATATAC

Product: hypothetical protein

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MVLNINSFYKNCRGEFMRAVFIYHKNNQRMEKFYKNLLNEPDFCRICDDCYNCRGNWTFKNNVKNIVIEEVYEEFVDNPY
DYLPELPEGDICIAQLHEDLLYELPLLLKEKGYKALIVPSETPHDLSLALRRDLKRVCSNYNIEFENPKPFCSLEKKEGN
EYINKFIDYFKIGKPELEIEVENGLIKDVKVKISAPCGETYYIAKRLKGKAIDDLKEEIANAHHNYPCLASMEMDKELGD
TILHKAGYIAFEVVEKALKK

Sequences:

>Translated_260_residues
MVLNINSFYKNCRGEFMRAVFIYHKNNQRMEKFYKNLLNEPDFCRICDDCYNCRGNWTFKNNVKNIVIEEVYEEFVDNPY
DYLPELPEGDICIAQLHEDLLYELPLLLKEKGYKALIVPSETPHDLSLALRRDLKRVCSNYNIEFENPKPFCSLEKKEGN
EYINKFIDYFKIGKPELEIEVENGLIKDVKVKISAPCGETYYIAKRLKGKAIDDLKEEIANAHHNYPCLASMEMDKELGD
TILHKAGYIAFEVVEKALKK
>Mature_260_residues
MVLNINSFYKNCRGEFMRAVFIYHKNNQRMEKFYKNLLNEPDFCRICDDCYNCRGNWTFKNNVKNIVIEEVYEEFVDNPY
DYLPELPEGDICIAQLHEDLLYELPLLLKEKGYKALIVPSETPHDLSLALRRDLKRVCSNYNIEFENPKPFCSLEKKEGN
EYINKFIDYFKIGKPELEIEVENGLIKDVKVKISAPCGETYYIAKRLKGKAIDDLKEEIANAHHNYPCLASMEMDKELGD
TILHKAGYIAFEVVEKALKK

Specific function: Is able to catalyze the biosynthesis of dTMP using dUMP, tetrahydrofolate and formaldehyde in vitro, i.e. a reaction equivalent to that catalyzed by bacterial thymidylate synthases (EC 2.1.1.45). However, M.jannaschii like most methanogenic Archaea lacks

COG id: COG1810

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TMPS_METJA (Q58167)

Other databases:

- EMBL:   L77117
- PIR:   E64394
- RefSeq:   NP_247742.1
- ProteinModelPortal:   Q58167
- GeneID:   1451634
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0757
- NMPDR:   fig|243232.1.peg.779
- TIGR:   MJ0757
- HOGENOM:   HBG555178
- OMA:   YPCTASM
- ProtClustDB:   CLSK796556
- BioCyc:   MetaCyc:MONOMER-14571
- BioCyc:   MJAN243232:MJ_0757-MONOMER
- InterPro:   IPR003745

Pfam domain/function: PF02593 DUF166

EC number: NA

Molecular weight: Translated: 30434; Mature: 30434

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLNINSFYKNCRGEFMRAVFIYHKNNQRMEKFYKNLLNEPDFCRICDDCYNCRGNWTFK
CEEECHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEC
NNVKNIVIEEVYEEFVDNPYDYLPELPEGDICIAQLHEDLLYELPLLLKEKGYKALIVPS
CCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
ETPHDLSLALRRDLKRVCSNYNIEFENPKPFCSLEKKEGNEYINKFIDYFKIGKPELEIE
CCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCEEEE
VENGLIKDVKVKISAPCGETYYIAKRLKGKAIDDLKEEIANAHHNYPCLASMEMDKELGD
ECCCCEEEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
TILHKAGYIAFEVVEKALKK
HHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVLNINSFYKNCRGEFMRAVFIYHKNNQRMEKFYKNLLNEPDFCRICDDCYNCRGNWTFK
CEEECHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEC
NNVKNIVIEEVYEEFVDNPYDYLPELPEGDICIAQLHEDLLYELPLLLKEKGYKALIVPS
CCHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECC
ETPHDLSLALRRDLKRVCSNYNIEFENPKPFCSLEKKEGNEYINKFIDYFKIGKPELEIE
CCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHCCHHHHHHHHHHHHCCCCCEEEE
VENGLIKDVKVKISAPCGETYYIAKRLKGKAIDDLKEEIANAHHNYPCLASMEMDKELGD
ECCCCEEEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
TILHKAGYIAFEVVEKALKK
HHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087