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Identifier: 15668905

GI number: 15668905

Start: 657185

End: 657808

Strand: Reverse

Name: ogg

Synonym: MJ0724

Alternate gene names: 15668905

Gene position: 657808-657185 (Counterclockwise)

Preceding gene: 15668906

Following gene: 15668903

Centisome position: 39.51

GC content: 29.81

Gene sequence:

>624_bases
ATGATGCTAATTAAAAAGATTGAAGAATTAAAAAACTCAGAAATTAAAGATATTATTGACAAAAGAATCCAGGAATTTAA
ATCTTTTAAAAATAAATCTAATGAGGAGTGGTTTAAAGAGCTGTGTTTTTGCATCTTAACAGCTAATTTTACAGCTGAAG
GAGGAATAAGAATTCAGAAAGAAATAGGAGATGGGTTTTTAACACTCCCAAGAGAAGAGTTAGAAGAGAAATTAAAAAAT
TTAGGTCACAGATTCTATAGAAAGAGAGCAGAGTATATTGTTTTAGCAAGGAGATTTAAAAACATTAAAGATATTGTTGA
GAGTTTTGAAAACGAGAAAGTAGCAAGAGAGTTTTTAGTAAGAAACATAAAGGGGATTGGATATAAAGAGGCGAGCCACT
TTTTGAGGAATGTTGGTTATGATGATGTTGCTATAATAGATAGGCATATATTGAGGGAACTCTATGAAAACAACTACATT
GATGAGATTCCAAAGACATTGAGTAGGAGAAAATACTTAGAGATTGAAAATATATTGAGAGACATTGGAGAAGAGGTTAA
TTTAAAACTCTCTGAATTGGATTTGTATATCTGGTATTTAAGGACAGGAAAAGTTTTAAAATAA

Upstream 100 bases:

>100_bases
TTTAAAATATAATGCTTTTTTATTTTTGAAATCTAACCGTAAGAGATATGAATTTAGTTTTTAATAAAATTTTTCTGTTT
TTTATAACTTTAGTGGTGAT

Downstream 100 bases:

>100_bases
AAACAATAAGTTTATTTCATTTGCTCTAAAATAATTGCTGGGCAAATCTTTTTTATTCCTTCAATCTTTCCAATTTTGTT
AAATATTAAGTCAGAGAACT

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MMLIKKIEELKNSEIKDIIDKRIQEFKSFKNKSNEEWFKELCFCILTANFTAEGGIRIQKEIGDGFLTLPREELEEKLKN
LGHRFYRKRAEYIVLARRFKNIKDIVESFENEKVAREFLVRNIKGIGYKEASHFLRNVGYDDVAIIDRHILRELYENNYI
DEIPKTLSRRKYLEIENILRDIGEEVNLKLSELDLYIWYLRTGKVLK

Sequences:

>Translated_207_residues
MMLIKKIEELKNSEIKDIIDKRIQEFKSFKNKSNEEWFKELCFCILTANFTAEGGIRIQKEIGDGFLTLPREELEEKLKN
LGHRFYRKRAEYIVLARRFKNIKDIVESFENEKVAREFLVRNIKGIGYKEASHFLRNVGYDDVAIIDRHILRELYENNYI
DEIPKTLSRRKYLEIENILRDIGEEVNLKLSELDLYIWYLRTGKVLK
>Mature_207_residues
MMLIKKIEELKNSEIKDIIDKRIQEFKSFKNKSNEEWFKELCFCILTANFTAEGGIRIQKEIGDGFLTLPREELEEKLKN
LGHRFYRKRAEYIVLARRFKNIKDIVESFENEKVAREFLVRNIKGIGYKEASHFLRNVGYDDVAIIDRHILRELYENNYI
DEIPKTLSRRKYLEIENILRDIGEEVNLKLSELDLYIWYLRTGKVLK

Specific function: Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG

COG id: COG1059

COG function: function code L; Thermostable 8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-2 OGG1 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OGG1_METJA (Q58134)

Other databases:

- EMBL:   L77117
- PIR:   D64390
- RefSeq:   NP_247709.1
- PDB:   3FHF
- PDB:   3KNT
- PDBsum:   3FHF
- PDBsum:   3KNT
- ProteinModelPortal:   Q58134
- SMR:   Q58134
- GeneID:   1451601
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0724
- NMPDR:   fig|243232.1.peg.746
- TIGR:   MJ0724
- HOGENOM:   HBG430608
- OMA:   FSELSFC
- ProtClustDB:   PRK01229
- BioCyc:   MJAN243232:MJ_0724-MONOMER
- BRENDA:   4.2.99.18
- HAMAP:   MF_00241
- InterPro:   IPR012092
- InterPro:   IPR011257
- InterPro:   IPR003265
- PIRSF:   PIRSF005954
- SMART:   SM00478

Pfam domain/function: SSF48150 DNA_glycsylse

EC number: =4.2.99.18

Molecular weight: Translated: 24827; Mature: 24827

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLIKKIEELKNSEIKDIIDKRIQEFKSFKNKSNEEWFKELCFCILTANFTAEGGIRIQK
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEHH
EIGDGFLTLPREELEEKLKNLGHRFYRKRAEYIVLARRFKNIKDIVESFENEKVAREFLV
HHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNIKGIGYKEASHFLRNVGYDDVAIIDRHILRELYENNYIDEIPKTLSRRKYLEIENILR
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DIGEEVNLKLSELDLYIWYLRTGKVLK
HCCHHHCCCHHHHHEEEEEECCCCCCC
>Mature Secondary Structure
MMLIKKIEELKNSEIKDIIDKRIQEFKSFKNKSNEEWFKELCFCILTANFTAEGGIRIQK
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEHH
EIGDGFLTLPREELEEKLKNLGHRFYRKRAEYIVLARRFKNIKDIVESFENEKVAREFLV
HHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNIKGIGYKEASHFLRNVGYDDVAIIDRHILRELYENNYIDEIPKTLSRRKYLEIENILR
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DIGEEVNLKLSELDLYIWYLRTGKVLK
HCCHHHCCCHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10521423