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The map label for this gene is hmgA

Identifier: 15668887

GI number: 15668887

Start: 632219

End: 633436

Strand: Direct

Name: hmgA

Synonym: MJ0705

Alternate gene names: 15668887

Gene position: 632219-633436 (Clockwise)

Preceding gene: 15668886

Following gene: 15668888

Centisome position: 37.97

GC content: 35.14

Gene sequence:

>1218_bases
ATGGAAAATTATAATGACATCCTTGAAAAAATGTTAAATGGAGAAATAAAGCCATATCAATTAGATAAAATGTTTGGTTC
AAAAATAGCAACTGAAATTAGAAGAAAATTTATTGAAAAAAAGGTTGGGATTGAATTTAAGCATATATGCAATTACTCAA
TAGATGAAGAAATGGCTATGAAGAAGAATATAGAAAATATGATTGGAGCTATACAGATTCCATTGGGTTTTGCTGGGCCT
TTAAAGATAAATGGGGAATATGCAAAGGGAGAGTTTTACATCCCATTGGCAACAACTGAAGGAGCTTTGGTGGCATCGGT
TAATAGGGGTTGCTCAATAATAACAAAATGTGGGGGGGCAACTGTTAGGGTTATAGATGATAAGATGACAAGAGCCCCTT
GCTTAAAAACAAAGAGTGTTGTAGATGCAATAAAAGTCAGAGATTGGATTAGAGAAAACTTTGAGAGGATAAAGGAAGTT
GCTGAATCAACAACAAGGCATGGAAAGCTAATAAAGATAGAGCCAATTTTAATCGTTGGAAGAAATCTATATCCAAGATT
TGTATTTAAAACTGGAGATGCCATGGGCATGAATATGGTTACAATTGCAACAGAGAAGGCATGTAATTTTATAGAGGGGG
AATTAAAAAAAGAAGGCATATTTGTTAAAACAGTTGCTGTCAGTGGAAATGCATGTGTAGATAAAAAGCCTAGTGGAATG
AACTTAATTAATGGTAGAGGGAAATCTATTGTAGCAGAGGTATTTTTAACTGAGAAGGAAGTTAATAAATACCTAAAAAC
CACTTCCCAAGCTATAGCTGAAGTAAATAGGTTAAAGAATTATATAGGTTCAGCAATAAGCAATTCAATGGGATTCAATG
CCCATTATGCAAATATCATTGGGGCAATATTCTTAGCTACTGGGCAAGATGAGGCACATATAGTTGAGGGTAGTTTAGGA
ATTACAATGGCTGAAGTTGAAGATGATGGATTATATTTTTCAGTAACTCTCCCAGATGTTCCTATTGGGACTGTTGGAGG
AGGAACAAGGGTTGAAACACAAAAAGAGTGCTTAGAGATGCTTGGTTGCTACGGAGATAATAAAGCTTTAAAATTTGCTG
AAATTGTTGGAGCTGCAGTTTTAGCTGGGGAGTTATCTTTATTAGGAGCTTTAGCAGCTGGACATTTAGGAAAAGCTCAT
CAAGAACTCGGTAGATAA

Upstream 100 bases:

>100_bases
ACGAACTAAAAGATGAACTCGAAAAACTAATTAATAAATGCAATAATAAACTAAGAGAACTTGAATCACAAAATAACAAC
TAAACTAATCTGGTGATAAA

Downstream 100 bases:

>100_bases
TTATGAGAGATGCTTATTTAATGATGGTGCTAATGGACGCATTGAAAGAGATATTTGATTTAAAAGAAATTCTAAAAAGC
CCTATAAGAAATAAGAAAGT

Product: 3-hydroxy-3-methylglutaryl coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MENYNDILEKMLNGEIKPYQLDKMFGSKIATEIRRKFIEKKVGIEFKHICNYSIDEEMAMKKNIENMIGAIQIPLGFAGP
LKINGEYAKGEFYIPLATTEGALVASVNRGCSIITKCGGATVRVIDDKMTRAPCLKTKSVVDAIKVRDWIRENFERIKEV
AESTTRHGKLIKIEPILIVGRNLYPRFVFKTGDAMGMNMVTIATEKACNFIEGELKKEGIFVKTVAVSGNACVDKKPSGM
NLINGRGKSIVAEVFLTEKEVNKYLKTTSQAIAEVNRLKNYIGSAISNSMGFNAHYANIIGAIFLATGQDEAHIVEGSLG
ITMAEVEDDGLYFSVTLPDVPIGTVGGGTRVETQKECLEMLGCYGDNKALKFAEIVGAAVLAGELSLLGALAAGHLGKAH
QELGR

Sequences:

>Translated_405_residues
MENYNDILEKMLNGEIKPYQLDKMFGSKIATEIRRKFIEKKVGIEFKHICNYSIDEEMAMKKNIENMIGAIQIPLGFAGP
LKINGEYAKGEFYIPLATTEGALVASVNRGCSIITKCGGATVRVIDDKMTRAPCLKTKSVVDAIKVRDWIRENFERIKEV
AESTTRHGKLIKIEPILIVGRNLYPRFVFKTGDAMGMNMVTIATEKACNFIEGELKKEGIFVKTVAVSGNACVDKKPSGM
NLINGRGKSIVAEVFLTEKEVNKYLKTTSQAIAEVNRLKNYIGSAISNSMGFNAHYANIIGAIFLATGQDEAHIVEGSLG
ITMAEVEDDGLYFSVTLPDVPIGTVGGGTRVETQKECLEMLGCYGDNKALKFAEIVGAAVLAGELSLLGALAAGHLGKAH
QELGR
>Mature_405_residues
MENYNDILEKMLNGEIKPYQLDKMFGSKIATEIRRKFIEKKVGIEFKHICNYSIDEEMAMKKNIENMIGAIQIPLGFAGP
LKINGEYAKGEFYIPLATTEGALVASVNRGCSIITKCGGATVRVIDDKMTRAPCLKTKSVVDAIKVRDWIRENFERIKEV
AESTTRHGKLIKIEPILIVGRNLYPRFVFKTGDAMGMNMVTIATEKACNFIEGELKKEGIFVKTVAVSGNACVDKKPSGM
NLINGRGKSIVAEVFLTEKEVNKYLKTTSQAIAEVNRLKNYIGSAISNSMGFNAHYANIIGAIFLATGQDEAHIVEGSLG
ITMAEVEDDGLYFSVTLPDVPIGTVGGGTRVETQKECLEMLGCYGDNKALKFAEIVGAAVLAGELSLLGALAAGHLGKAH
QELGR

Specific function: Converts HMG-CoA to mevalonate

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family

Homologues:

Organism=Homo sapiens, GI4557643, Length=410, Percent_Identity=43.1707317073171, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI196049380, Length=295, Percent_Identity=47.1186440677966, Blast_Score=242, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI25144592, Length=405, Percent_Identity=41.7283950617284, Blast_Score=291, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6323565, Length=408, Percent_Identity=39.9509803921569, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6323483, Length=418, Percent_Identity=39.9521531100478, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI281362379, Length=390, Percent_Identity=42.3076923076923, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI45553469, Length=390, Percent_Identity=42.3076923076923, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24649399, Length=390, Percent_Identity=42.3076923076923, Blast_Score=247, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMDH_METJA (Q58116)

Other databases:

- EMBL:   L77117
- PIR:   A64388
- RefSeq:   NP_247690.1
- ProteinModelPortal:   Q58116
- SMR:   Q58116
- GeneID:   1451573
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0705
- NMPDR:   fig|243232.1.peg.727
- TIGR:   MJ0705
- HOGENOM:   HBG604528
- OMA:   NAHYANM
- ProtClustDB:   CLSK865250
- BioCyc:   MJAN243232:MJ_0705-MONOMER
- BRENDA:   1.1.1.34
- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029
- Gene3D:   G3DSA:3.90.770.10
- PANTHER:   PTHR10572
- PRINTS:   PR00071
- TIGRFAMs:   TIGR00533

Pfam domain/function: PF00368 HMG-CoA_red; SSF55035 HMG_CoA_NAD_bind; SSF56542 HMG_CoA_sub_bind

EC number: =1.1.1.34

Molecular weight: Translated: 44129; Mature: 44129

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS00066 HMG_COA_REDUCTASE_1; PS00318 HMG_COA_REDUCTASE_2; PS01192 HMG_COA_REDUCTASE_3; PS50065 HMG_COA_REDUCTASE_4

Important sites: ACT_SITE 100-100 ACT_SITE 310-310 ACT_SITE 400-400

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENYNDILEKMLNGEIKPYQLDKMFGSKIATEIRRKFIEKKVGIEFKHICNYSIDEEMAM
CCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHH
KKNIENMIGAIQIPLGFAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSIITKCGGA
HHHHHHHHCEEEECCCCCCCEEECCEEECCEEEEEEECCCCCEEEECCCCCEEEEECCCC
TVRVIDDKMTRAPCLKTKSVVDAIKVRDWIRENFERIKEVAESTTRHGKLIKIEPILIVG
EEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEC
RNLYPRFVFKTGDAMGMNMVTIATEKACNFIEGELKKEGIFVKTVAVSGNACVDKKPSGM
CCCCCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCC
NLINGRGKSIVAEVFLTEKEVNKYLKTTSQAIAEVNRLKNYIGSAISNSMGFNAHYANII
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GAIFLATGQDEAHIVEGSLGITMAEVEDDGLYFSVTLPDVPIGTVGGGTRVETQKECLEM
HHHHEECCCCCCEEEECCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
LGCYGDNKALKFAEIVGAAVLAGELSLLGALAAGHLGKAHQELGR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MENYNDILEKMLNGEIKPYQLDKMFGSKIATEIRRKFIEKKVGIEFKHICNYSIDEEMAM
CCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHH
KKNIENMIGAIQIPLGFAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSIITKCGGA
HHHHHHHHCEEEECCCCCCCEEECCEEECCEEEEEEECCCCCEEEECCCCCEEEEECCCC
TVRVIDDKMTRAPCLKTKSVVDAIKVRDWIRENFERIKEVAESTTRHGKLIKIEPILIVG
EEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEC
RNLYPRFVFKTGDAMGMNMVTIATEKACNFIEGELKKEGIFVKTVAVSGNACVDKKPSGM
CCCCCEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCC
NLINGRGKSIVAEVFLTEKEVNKYLKTTSQAIAEVNRLKNYIGSAISNSMGFNAHYANII
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
GAIFLATGQDEAHIVEGSLGITMAEVEDDGLYFSVTLPDVPIGTVGGGTRVETQKECLEM
HHHHEECCCCCCEEEECCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
LGCYGDNKALKFAEIVGAAVLAGELSLLGALAAGHLGKAHQELGR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087