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The map label for this gene is nadA

Identifier: 15668583

GI number: 15668583

Start: 366473

End: 367396

Strand: Direct

Name: nadA

Synonym: MJ0407

Alternate gene names: 15668583

Gene position: 366473-367396 (Clockwise)

Preceding gene: 15668582

Following gene: 15668584

Centisome position: 22.01

GC content: 32.68

Gene sequence:

>924_bases
ATGTCTATGGATATAGTAGAAAGAATAAACAAATTAAAAGAAGAAAAAAATGCAGTAATATTGGCTCACAATTATCAACC
AAAGGAGATACAGAAAATAGCTGATTTTCTTGGAGATTCATTAGAGTTGTGTATAAAGGCAAAAGAAACAGATGCTGACA
TAATAGTATTTTGTGGAGTAGATTTTATGGGAGAGTCAGCAAAAATTTTGAATCCAGAGAAAAAAGTTTTGATGCCAGAG
ATTGAAGGAACCCAATGCCCAATGGCTCACCAACTACCCCCAGAGATTATAAAGAAGTATAGAGAGCTTTATCCAGAGGC
TCCATTGGTTGTTTATGTGAATACAACAGCAGAGACAAAAGCATTAGCTGATATTACATGCACATCAGCAAATGCAGATA
GAGTAGTTAATTCCTTGGATGCTGATACAGTTTTATTTGGTCCGGATAACAACTTAGCTTATTATGTGCAAAAAAGAACT
GATAAAAAAGTTATAGCTATTCCTGAAGGGGGAGGTTGTTATGTGCATAAAAAATTCACAATAGATGATTTAAAGAGAGT
TAAAAGCAAATATCCAAATGCTAAAGTTTTAATTCATCCAGAATGTAGTCCAGAATTGCAAGATAATGCTGATTACATAG
CAAGCACAAGTGGAATATTGAGGATTGTTTTAGAGTCAGATGATGAAGAGTTTATAATTGGCACTGAAGTTGGAATGATA
AATAGATTGGAGATAGAGCTTGAAAAATTGGGTAAAAAGAAAACCTTAATTCCATTGAGGAAAGATGCTATTTGCCACGA
GATGAAAAGAATAACATTGGAGAAGATAGAAAAATGTTTATTAGAGGAGAGATATGAAATTAAATTAGAGAAAGAGATTA
TTGAAAAAGCTCAAAAAGCTATTGAAAGAATGCTTAGAATTTAG

Upstream 100 bases:

>100_bases
TGTTGTTGAGGCAAAGGGATGCCAAACTAATTTACCAACATGGGATAAGGTTGTTGAGAGATTAGAAAAACACCGAATAT
AAAATATAATTTTTTGAGGG

Downstream 100 bases:

>100_bases
TGTCTTTCAAAAAATAAAAATTTATTAATGAACTTTTGAACGCCTTCCAAAGGAAGACGTTCGTTAGTGCAAATGGTTAT
CCAAGAAGTTTTGAAAGACA

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSMDIVERINKLKEEKNAVILAHNYQPKEIQKIADFLGDSLELCIKAKETDADIIVFCGVDFMGESAKILNPEKKVLMPE
IEGTQCPMAHQLPPEIIKKYRELYPEAPLVVYVNTTAETKALADITCTSANADRVVNSLDADTVLFGPDNNLAYYVQKRT
DKKVIAIPEGGGCYVHKKFTIDDLKRVKSKYPNAKVLIHPECSPELQDNADYIASTSGILRIVLESDDEEFIIGTEVGMI
NRLEIELEKLGKKKTLIPLRKDAICHEMKRITLEKIEKCLLEERYEIKLEKEIIEKAQKAIERMLRI

Sequences:

>Translated_307_residues
MSMDIVERINKLKEEKNAVILAHNYQPKEIQKIADFLGDSLELCIKAKETDADIIVFCGVDFMGESAKILNPEKKVLMPE
IEGTQCPMAHQLPPEIIKKYRELYPEAPLVVYVNTTAETKALADITCTSANADRVVNSLDADTVLFGPDNNLAYYVQKRT
DKKVIAIPEGGGCYVHKKFTIDDLKRVKSKYPNAKVLIHPECSPELQDNADYIASTSGILRIVLESDDEEFIIGTEVGMI
NRLEIELEKLGKKKTLIPLRKDAICHEMKRITLEKIEKCLLEERYEIKLEKEIIEKAQKAIERMLRI
>Mature_306_residues
SMDIVERINKLKEEKNAVILAHNYQPKEIQKIADFLGDSLELCIKAKETDADIIVFCGVDFMGESAKILNPEKKVLMPEI
EGTQCPMAHQLPPEIIKKYRELYPEAPLVVYVNTTAETKALADITCTSANADRVVNSLDADTVLFGPDNNLAYYVQKRTD
KKVIAIPEGGGCYVHKKFTIDDLKRVKSKYPNAKVLIHPECSPELQDNADYIASTSGILRIVLESDDEEFIIGTEVGMIN
RLEIELEKLGKKKTLIPLRKDAICHEMKRITLEKIEKCLLEERYEIKLEKEIIEKAQKAIERMLRI

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=315, Percent_Identity=32.6984126984127, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_METJA (Q57850)

Other databases:

- EMBL:   L77117
- PIR:   G64350
- RefSeq:   NP_247381.1
- ProteinModelPortal:   Q57850
- GeneID:   1451267
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0407
- NMPDR:   fig|243232.1.peg.418
- TIGR:   MJ0407
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- BioCyc:   MJAN243232:MJ_0407-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 34863; Mature: 34732

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: BINDING 23-23 BINDING 40-40 BINDING 112-112 BINDING 129-129 BINDING 199-199 BINDING 216-216

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMDIVERINKLKEEKNAVILAHNYQPKEIQKIADFLGDSLELCIKAKETDADIIVFCGV
CCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECC
DFMGESAKILNPEKKVLMPEIEGTQCPMAHQLPPEIIKKYRELYPEAPLVVYVNTTAETK
CCCCCCCEECCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHH
ALADITCTSANADRVVNSLDADTVLFGPDNNLAYYVQKRTDKKVIAIPEGGGCYVHKKFT
HEEEEEECCCCHHHHHHHCCCCEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEEECC
IDDLKRVKSKYPNAKVLIHPECSPELQDNADYIASTSGILRIVLESDDEEFIIGTEVGMI
HHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEECCCCEEEEEEECCCCCEEEECCCCCE
NRLEIELEKLGKKKTLIPLRKDAICHEMKRITLEKIEKCLLEERYEIKLEKEIIEKAQKA
EHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHH
IERMLRI
HHHHHCC
>Mature Secondary Structure 
SMDIVERINKLKEEKNAVILAHNYQPKEIQKIADFLGDSLELCIKAKETDADIIVFCGV
CHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECC
DFMGESAKILNPEKKVLMPEIEGTQCPMAHQLPPEIIKKYRELYPEAPLVVYVNTTAETK
CCCCCCCEECCCCHHEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHH
ALADITCTSANADRVVNSLDADTVLFGPDNNLAYYVQKRTDKKVIAIPEGGGCYVHKKFT
HEEEEEECCCCHHHHHHHCCCCEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEEEECC
IDDLKRVKSKYPNAKVLIHPECSPELQDNADYIASTSGILRIVLESDDEEFIIGTEVGMI
HHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEECCCCEEEEEEECCCCCEEEECCCCCE
NRLEIELEKLGKKKTLIPLRKDAICHEMKRITLEKIEKCLLEERYEIKLEKEIIEKAQKA
EHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHH
IERMLRI
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087