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The map label for this gene is manB

Identifier: 15668575

GI number: 15668575

Start: 360151

End: 361500

Strand: Reverse

Name: manB

Synonym: MJ0399

Alternate gene names: 15668575

Gene position: 361500-360151 (Counterclockwise)

Preceding gene: 15668577

Following gene: 15668573

Centisome position: 21.71

GC content: 29.41

Gene sequence:

>1350_bases
GTGTTTGGTGATTTGATGGTATTTAAAGCCTATGATATTAGAGGAATCTATGGTAGAGAGTTAGATGAGAACTTTGCCTA
TTCCTTAGGAAAGTGCATTGGTAAAAAATTTGAAAATAAAAAGATATTAGTTGGAAATGACGTTAGAATTGGTTCCAAAG
AGCTTTTACCCTATTTTATAGTTGGTTTGAAAGAATATGCGGATGTATTTTATGCCGGAACTATTTCAACCCCTTTAATG
TATTTCGGAACTAAAGGAAAATATGATTTAGGAGTTATATTAACAGCATCTCATAACCCTCCAGAATACACTGGATTTAA
GATGTGTGATAAAGAAGCTATTCCTCTGTCACCAATAGAAGAGATAAAACCAATATTCAAAAAATATGAATTAACAGAAA
GTATAAAAGAAGAAGCTAAAAACCTAAATTTAGATGATTTAAAGGTTAATATTATAGAGGAGTATAAAAAATTCTTTTTA
AAGAGATGTAAAGCCTCAGATAAAAAAATAGCTGTAGATTTTGCAAATGGAGCTACTACAATAGCTGAAAAAGAAATTTT
GAATGAATTGTTTGATAACGCAGTTTTTATAAATGATTATCCCGATGGCAATTTCCCTGCTCATCAACCAGACACACTAA
AAATGGAATGCTTAAAAGATATTATAAGAGCAGTTAAAAAAAATAACTGTGAATTAGGTTTAATATTTGACGGAGATGGA
GATAGGTTGGGAATAGTTGATGAAAACGGAAATGTTTTGAGGGGAGATATATTAACAGCCATAATAGCAAAAGAAATTTT
AAAAGAAAAGTCAAATGCCAAAATTGTTTATGATTTAAGATGTTCTAAAATAGTTCCAGAAATTATTGAGAAGTATGGTG
GCATAGCAATAAAAAGTAGAGTGGGGCATTACTTTATAAAAAAATTAATGCATGAAATAGATGCTGAATTTGCTGGAGAG
TTGAGTAATCACTTTTACTTTAAAGAGATTGGCTACTTTGAAAGTCCATTACTGGCGTTAAATTATATCTTAAAAGCTAT
GGATGAAGAAAATAAATCATTATCTGAACTAAATAAGGAATTTAGCAAATATCCTCATAGTGGAGAGATAAACTTTAGAG
TTAAAGACCAAAAATATATTATGGAAAAAATAAAGGAACATTTTAAAGATTGCAAGTTAGAGGAGTTGGATGGAATATCT
ATTTATTGTAAAAACTTCTGGTTTAATTTAAGACCTTCAAATACTGAACCATTATTAAGATTAAACTTAGAAGCAGATGA
TGAGAAAACAATGAAAGAGAAGGTTGAAGAGATTAAAAATCTAATTGCAAAGCTTGATGCATCCTTATAA

Upstream 100 bases:

>100_bases
AATAATTCCATATTCTCACATTTACAAATTTTTATTGTTTTATTTGATATTAATGTTAAAGTTTTAATATAGAAATATCA
GATATCAATATTTAAAATTT

Downstream 100 bases:

>100_bases
TTCATTTTTATGGTTGTGTCTTTAATATACACACAACCAAAACCTTTATATATTAGTTTGTAGTTATAGTAATTTCGCTT
GTTTTGGATTAAAAGTTGAG

Product: phosphomannomutase PmmA

Products: NA

Alternate protein names: PMM

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFGDLMVFKAYDIRGIYGRELDENFAYSLGKCIGKKFENKKILVGNDVRIGSKELLPYFIVGLKEYADVFYAGTISTPLM
YFGTKGKYDLGVILTASHNPPEYTGFKMCDKEAIPLSPIEEIKPIFKKYELTESIKEEAKNLNLDDLKVNIIEEYKKFFL
KRCKASDKKIAVDFANGATTIAEKEILNELFDNAVFINDYPDGNFPAHQPDTLKMECLKDIIRAVKKNNCELGLIFDGDG
DRLGIVDENGNVLRGDILTAIIAKEILKEKSNAKIVYDLRCSKIVPEIIEKYGGIAIKSRVGHYFIKKLMHEIDAEFAGE
LSNHFYFKEIGYFESPLLALNYILKAMDEENKSLSELNKEFSKYPHSGEINFRVKDQKYIMEKIKEHFKDCKLEELDGIS
IYCKNFWFNLRPSNTEPLLRLNLEADDEKTMKEKVEEIKNLIAKLDASL

Sequences:

>Translated_449_residues
MFGDLMVFKAYDIRGIYGRELDENFAYSLGKCIGKKFENKKILVGNDVRIGSKELLPYFIVGLKEYADVFYAGTISTPLM
YFGTKGKYDLGVILTASHNPPEYTGFKMCDKEAIPLSPIEEIKPIFKKYELTESIKEEAKNLNLDDLKVNIIEEYKKFFL
KRCKASDKKIAVDFANGATTIAEKEILNELFDNAVFINDYPDGNFPAHQPDTLKMECLKDIIRAVKKNNCELGLIFDGDG
DRLGIVDENGNVLRGDILTAIIAKEILKEKSNAKIVYDLRCSKIVPEIIEKYGGIAIKSRVGHYFIKKLMHEIDAEFAGE
LSNHFYFKEIGYFESPLLALNYILKAMDEENKSLSELNKEFSKYPHSGEINFRVKDQKYIMEKIKEHFKDCKLEELDGIS
IYCKNFWFNLRPSNTEPLLRLNLEADDEKTMKEKVEEIKNLIAKLDASL
>Mature_449_residues
MFGDLMVFKAYDIRGIYGRELDENFAYSLGKCIGKKFENKKILVGNDVRIGSKELLPYFIVGLKEYADVFYAGTISTPLM
YFGTKGKYDLGVILTASHNPPEYTGFKMCDKEAIPLSPIEEIKPIFKKYELTESIKEEAKNLNLDDLKVNIIEEYKKFFL
KRCKASDKKIAVDFANGATTIAEKEILNELFDNAVFINDYPDGNFPAHQPDTLKMECLKDIIRAVKKNNCELGLIFDGDG
DRLGIVDENGNVLRGDILTAIIAKEILKEKSNAKIVYDLRCSKIVPEIIEKYGGIAIKSRVGHYFIKKLMHEIDAEFAGE
LSNHFYFKEIGYFESPLLALNYILKAMDEENKSLSELNKEFSKYPHSGEINFRVKDQKYIMEKIKEHFKDCKLEELDGIS
IYCKNFWFNLRPSNTEPLLRLNLEADDEKTMKEKVEEIKNLIAKLDASL

Specific function: Involved In The Biosynthesis Of The Capsular Polysaccharide Colanic Acid. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family

Homologues:

Organism=Escherichia coli, GI1788361, Length=455, Percent_Identity=31.4285714285714, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789566, Length=446, Percent_Identity=26.457399103139, Blast_Score=112, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MANB_METJA (Q57842)

Other databases:

- EMBL:   L77117
- PIR:   G64349
- RefSeq:   NP_247373.1
- ProteinModelPortal:   Q57842
- SMR:   Q57842
- GeneID:   1451259
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0399
- NMPDR:   fig|243232.1.peg.410
- TIGR:   MJ0399
- HOGENOM:   HBG644964
- OMA:   RDAYIGH
- ProtClustDB:   CLSK876169
- BioCyc:   MJAN243232:MJ_0399-MONOMER
- BRENDA:   5.4.2.8
- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841
- Gene3D:   G3DSA:3.40.120.10
- PRINTS:   PR00509

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV; SSF53738 A-D-PHexomutase_a/b/a-I/II/III

EC number: =5.4.2.8

Molecular weight: Translated: 51474; Mature: 51474

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00710 PGM_PMM

Important sites: ACT_SITE 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDLMVFKAYDIRGIYGRELDENFAYSLGKCIGKKFENKKILVGNDVRIGSKELLPYFI
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
VGLKEYADVFYAGTISTPLMYFGTKGKYDLGVILTASHNPPEYTGFKMCDKEAIPLSPIE
HHHHHHHHHEEECCCCCCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHH
EIKPIFKKYELTESIKEEAKNLNLDDLKVNIIEEYKKFFLKRCKASDKKIAVDFANGATT
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
IAEKEILNELFDNAVFINDYPDGNFPAHQPDTLKMECLKDIIRAVKKNNCELGLIFDGDG
HHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
DRLGIVDENGNVLRGDILTAIIAKEILKEKSNAKIVYDLRCSKIVPEIIEKYGGIAIKSR
CEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCEEEEHH
VGHYFIKKLMHEIDAEFAGELSNHFYFKEIGYFESPLLALNYILKAMDEENKSLSELNKE
HHHHHHHHHHHHHCHHHHHHHHCCEEEHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
FSKYPHSGEINFRVKDQKYIMEKIKEHFKDCKLEELDGISIYCKNFWFNLRPSNTEPLLR
HHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCEEEECCCCCCCEEE
LNLEADDEKTMKEKVEEIKNLIAKLDASL
EECCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFGDLMVFKAYDIRGIYGRELDENFAYSLGKCIGKKFENKKILVGNDVRIGSKELLPYFI
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHH
VGLKEYADVFYAGTISTPLMYFGTKGKYDLGVILTASHNPPEYTGFKMCDKEAIPLSPIE
HHHHHHHHHEEECCCCCCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHH
EIKPIFKKYELTESIKEEAKNLNLDDLKVNIIEEYKKFFLKRCKASDKKIAVDFANGATT
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
IAEKEILNELFDNAVFINDYPDGNFPAHQPDTLKMECLKDIIRAVKKNNCELGLIFDGDG
HHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
DRLGIVDENGNVLRGDILTAIIAKEILKEKSNAKIVYDLRCSKIVPEIIEKYGGIAIKSR
CEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCEEEEHH
VGHYFIKKLMHEIDAEFAGELSNHFYFKEIGYFESPLLALNYILKAMDEENKSLSELNKE
HHHHHHHHHHHHHCHHHHHHHHCCEEEHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
FSKYPHSGEINFRVKDQKYIMEKIKEHFKDCKLEELDGISIYCKNFWFNLRPSNTEPLLR
HHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCEEEECCCCCCCEEE
LNLEADDEKTMKEKVEEIKNLIAKLDASL
EECCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087