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The map label for this gene is 15668294

Identifier: 15668294

GI number: 15668294

Start: 118231

End: 119157

Strand: Reverse

Name: 15668294

Synonym: MJ0122

Alternate gene names: NA

Gene position: 119157-118231 (Counterclockwise)

Preceding gene: 15668295

Following gene: 15668293

Centisome position: 7.16

GC content: 33.98

Gene sequence:

>927_bases
TTGGTGTTTAAAATGAGTGAAATGGATATTATAAAAGAAACCTATGAAAAAATCAAAAATATGGAGATTAGGGGGGCGGG
GAGAATAGGAAGAGCAGCAGCTAAGGCATTAAAAGAATATGCTCTAAAAATTAGCCATTTAAATGAAGAAGAATTCAAAA
ATAAAATGAGAGAGGCAGGAAATATATTAATATCAGCAAGACCTACAGCTGTTTCTCTACCAAATGTTGTAAAGTATGTA
TTAAAGGGCTTAAATGAAGAAAATCCAAAAGAAAGAGTTATAGAGAGAGCTGATGAATTCATCAACTCATCATTAAAGGC
AATTGAAAATATAGGAAAGTTTGGAGCAAATAGAATAAAAGATGGAGACACTATCTTAACTCACTGCAACTCTGAAGCTG
CAATAAGCGTTATAAAAACTGCTTACGATGAAGGAAAAGATATCAAAGTTTTCTGCACAGAGACAAGACCAAGAAATCAG
GGATATTTAACAGCTAAAACCCTCTATGATTATGGTATTGATGTAACCCTAATAGTAGATTCTGCAGTGAGGTACTTTAT
AAAAGAGATAGATATTGTCGTCGTTGGAGCTGATGCCATAACAGCAAATGGTTGCCTTGTAAATAAAATAGGAACTTCAC
AAATTGCTTTAATAGCAAATGAAAGTAGAGTACCTTTTTTAACAGCCGCTGAAACATACAAATTCCATCCAAAGACTATA
GTTGGAGAGCTAATTGAGATAGAAGAAAGAAGCCCAGAGGAAGTTGCAGTTTTTGAAGATAAATACAAAGGAATAAAAAT
TAGGAATCCCGCATTTGATGTAACACCAGCTAAGTATATAGATGCTATAATAACAGAGGTGGGGTTAATTCCTCCACAGG
GAGCTTGGTATATAATAGAAAAATACTTTGGCTGGCTTGAGAAATAA

Upstream 100 bases:

>100_bases
AGAAACTATTTTTCTAAGAATGAATGTGATGAGATTGAATTAAAAATCATACAAAAACTTATATGATAAAAGAGATAAAA
AATTAATTTAAAATAAATTT

Downstream 100 bases:

>100_bases
ATAATTGTTGGAATAAAATATATATACCACAATTTGCATAAATTAATATATGTCCCGGGTGGCGACCTTCCGCAGGGGAT
GAAACCACCTCGGCATTCTA

Product: translation initiation factor IF-2B subunit delta

Products: NA

Alternate protein names: eIF-2B GDP-GTP exchange factor

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MVFKMSEMDIIKETYEKIKNMEIRGAGRIGRAAAKALKEYALKISHLNEEEFKNKMREAGNILISARPTAVSLPNVVKYV
LKGLNEENPKERVIERADEFINSSLKAIENIGKFGANRIKDGDTILTHCNSEAAISVIKTAYDEGKDIKVFCTETRPRNQ
GYLTAKTLYDYGIDVTLIVDSAVRYFIKEIDIVVVGADAITANGCLVNKIGTSQIALIANESRVPFLTAAETYKFHPKTI
VGELIEIEERSPEEVAVFEDKYKGIKIRNPAFDVTPAKYIDAIITEVGLIPPQGAWYIIEKYFGWLEK

Sequences:

>Translated_308_residues
MVFKMSEMDIIKETYEKIKNMEIRGAGRIGRAAAKALKEYALKISHLNEEEFKNKMREAGNILISARPTAVSLPNVVKYV
LKGLNEENPKERVIERADEFINSSLKAIENIGKFGANRIKDGDTILTHCNSEAAISVIKTAYDEGKDIKVFCTETRPRNQ
GYLTAKTLYDYGIDVTLIVDSAVRYFIKEIDIVVVGADAITANGCLVNKIGTSQIALIANESRVPFLTAAETYKFHPKTI
VGELIEIEERSPEEVAVFEDKYKGIKIRNPAFDVTPAKYIDAIITEVGLIPPQGAWYIIEKYFGWLEK
>Mature_308_residues
MVFKMSEMDIIKETYEKIKNMEIRGAGRIGRAAAKALKEYALKISHLNEEEFKNKMREAGNILISARPTAVSLPNVVKYV
LKGLNEENPKERVIERADEFINSSLKAIENIGKFGANRIKDGDTILTHCNSEAAISVIKTAYDEGKDIKVFCTETRPRNQ
GYLTAKTLYDYGIDVTLIVDSAVRYFIKEIDIVVVGADAITANGCLVNKIGTSQIALIANESRVPFLTAAETYKFHPKTI
VGELIEIEERSPEEVAVFEDKYKGIKIRNPAFDVTPAKYIDAIITEVGLIPPQGAWYIIEKYFGWLEK

Specific function: Catalyzes the exchange of initiation factor 2-bound GDP for GTP

COG id: COG1184

COG function: function code J; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family

Homologues:

Organism=Homo sapiens, GI72534748, Length=315, Percent_Identity=33.6507936507937, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI78000156, Length=278, Percent_Identity=27.3381294964029, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI78000158, Length=278, Percent_Identity=27.3381294964029, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI187607323, Length=278, Percent_Identity=27.3381294964029, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4503503, Length=212, Percent_Identity=31.1320754716981, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI23943880, Length=304, Percent_Identity=29.6052631578947, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI7657058, Length=293, Percent_Identity=24.2320819112628, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17557462, Length=320, Percent_Identity=31.25, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17557123, Length=207, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322878, Length=270, Percent_Identity=30.7407407407407, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6325375, Length=359, Percent_Identity=30.6406685236769, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321520, Length=185, Percent_Identity=26.4864864864865, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357667, Length=325, Percent_Identity=34.4615384615385, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24651647, Length=325, Percent_Identity=34.4615384615385, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21358605, Length=254, Percent_Identity=29.1338582677165, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281364091, Length=249, Percent_Identity=31.3253012048193, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24659399, Length=249, Percent_Identity=31.3253012048193, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24659407, Length=249, Percent_Identity=31.3253012048193, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19922816, Length=249, Percent_Identity=31.3253012048193, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EI2B2_METJA (Q57586)

Other databases:

- EMBL:   L77117
- PIR:   B64315
- RefSeq:   NP_247087.1
- ProteinModelPortal:   Q57586
- GeneID:   1450965
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0122
- NMPDR:   fig|243232.1.peg.124
- TIGR:   MJ0122
- HOGENOM:   HBG682649
- OMA:   NKIGTSQ
- ProtClustDB:   PRK08535
- BioCyc:   MJAN243232:MJ_0122-MONOMER
- InterPro:   IPR005250
- InterPro:   IPR000649
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00511

Pfam domain/function: PF01008 IF-2B

EC number: NA

Molecular weight: Translated: 34518; Mature: 34518

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFKMSEMDIIKETYEKIKNMEIRGAGRIGRAAAKALKEYALKISHLNEEEFKNKMREAG
CEEECHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
NILISARPTAVSLPNVVKYVLKGLNEENPKERVIERADEFINSSLKAIENIGKFGANRIK
CEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGDTILTHCNSEAAISVIKTAYDEGKDIKVFCTETRPRNQGYLTAKTLYDYGIDVTLIVD
CCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEHHHCCCEEEEEHH
SAVRYFIKEIDIVVVGADAITANGCLVNKIGTSQIALIANESRVPFLTAAETYKFHPKTI
HHHHHHHHHCCEEEECCCEEEECCEEEECCCCCEEEEEECCCCCCEEEECCCEECCCHHH
VGELIEIEERSPEEVAVFEDKYKGIKIRNPAFDVTPAKYIDAIITEVGLIPPQGAWYIIE
HHHHHHHCCCCCCCEEEEHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEHH
KYFGWLEK
HHHHHHCC
>Mature Secondary Structure
MVFKMSEMDIIKETYEKIKNMEIRGAGRIGRAAAKALKEYALKISHLNEEEFKNKMREAG
CEEECHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
NILISARPTAVSLPNVVKYVLKGLNEENPKERVIERADEFINSSLKAIENIGKFGANRIK
CEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGDTILTHCNSEAAISVIKTAYDEGKDIKVFCTETRPRNQGYLTAKTLYDYGIDVTLIVD
CCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEHHHCCCEEEEEHH
SAVRYFIKEIDIVVVGADAITANGCLVNKIGTSQIALIANESRVPFLTAAETYKFHPKTI
HHHHHHHHHCCEEEECCCEEEECCEEEECCCCCEEEEEECCCCCCEEEECCCEECCCHHH
VGELIEIEERSPEEVAVFEDKYKGIKIRNPAFDVTPAKYIDAIITEVGLIPPQGAWYIIE
HHHHHHHCCCCCCCEEEEHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEHH
KYFGWLEK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087