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The map label for this gene is srp54

Identifier: 15668272

GI number: 15668272

Start: 95050

End: 96405

Strand: Reverse

Name: srp54

Synonym: MJ0101

Alternate gene names: 15668272

Gene position: 96405-95050 (Counterclockwise)

Preceding gene: 15668273

Following gene: 15668271

Centisome position: 5.79

GC content: 34.0

Gene sequence:

>1356_bases
ATGCTCGATAAATTAGGAGAAAATTTAAACAAAGCCCTAAACAAACTAAAAGCTGCTGCCTTTGTTGATAAAAAATTAAT
AAAAGAAGTTATAAAAGATATTCAAAGGGCTTTAATACAGGCAGATGTTAATGTAAAATTGGTTTTAAAGATGAGTAAAG
AAATAGAGAGGAGAGCTTTAGAGGAAAAGACACCAAAGGGTTTATCAAAGAAAGAGCATATCATAAAGATTGTCTATGAA
GAATTAGTCAAATTATTGGGAGAAGAGGCAAAAAAATTAGAGTTAAATCCAAAAAAACAAAATGTTATCTTATTAGTTGG
TATTCAAGGTTCAGGAAAAACAACAACTGCAGCAAAATTAGCAAGGTATATCCAAAAAAGAGGGTTAAAACCTGCTTTAA
TCGCAGCTGATACCTACAGACCAGCGGCTTATGAGCAGTTAAAGCAGTTAGCTGAAAAAATCCACGTGCCAATATATGGG
GATGAGACAAGAACAAAATCACCAGTAGATATTGTTAAAGAGGGGATGGAGAAATTTAAGAAGGCAGATGTTTTAATTAT
AGATACTGCTGGAAGACATAAAGAGGAAAAAGGTTTATTGGAAGAGATGAAGCAAATTAAAGAGATAACAAATCCAGATG
AAATCATATTGGTTATAGATGGGACTATTGGGCAACAAGCAGGAATTCAAGCTAAAGCGTTTAAAGAGGCAGTTGGAGAG
ATTGGGAGTATAATAGTAACTAAGTTAGATGGTTCTGCTAAAGGAGGAGGGGCGTTAAGTGCGGTTGCTGAGACAAAAGC
ACCTATAAAATTCATTGGAATTGGGGAGGGGATTGATGATTTAGAACCATTCGACCCTAAAAAATTTATATCTCGACTGT
TAGGGATGGGAGATTTAGAGAGCCTATTAGAAAAAGCTGAAGACATGGTTGATGAGAAAACAGAAGAAAGCATAGATGCA
ATAATGAGAGGGAAATTTACTTTAAATGAGTTGATGACTCAATTAGAAGCAATTGAAAACATGGGTTCAATGAAAAAAAT
CCTAAGTATGATTCCTGGATTTGGAGGAGCTATGCCTAAAGAGCTTTCTCATTTAACTGAGGCAAAGATAAAAAAATATA
AGGTAATTATAAGTTCAATGACTAAGGAAGAGAGAGAAAATCCAAAGATTATTAAAGCTTCAAGAATCAGAAGGATTGCA
AGAGGTTCTGGAACTACAGAAAATGATGTTAGGGAGGTTTTAAGATATTATGAAACAACAAAAAATGCCATAGATAAGTT
GAGAAAGGGTAAGATGTTGAGAATTGGAGGACCTTTAGGACAAATAATGAGACAATTAATGTTTAAGGAAGGATAA

Upstream 100 bases:

>100_bases
TGTTTAAAGTATAATTCTAAAATTTCTGAAAACAATAAAATTTTTAATTGAAGAAATATAATATTTTATTAAGTGTTGTA
TAGTTTAATTTGGTGATATC

Downstream 100 bases:

>100_bases
TTCTTTTTTATTTTCTATTTAGCAATTTTAATCTCAGATATAATAGAATCAAATACTTTAGAAGTTTAAAATTTTTATAT
CTCTTTTTATATATTTTAGG

Product: signal recognition particle protein Srp54

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLDKLGENLNKALNKLKAAAFVDKKLIKEVIKDIQRALIQADVNVKLVLKMSKEIERRALEEKTPKGLSKKEHIIKIVYE
ELVKLLGEEAKKLELNPKKQNVILLVGIQGSGKTTTAAKLARYIQKRGLKPALIAADTYRPAAYEQLKQLAEKIHVPIYG
DETRTKSPVDIVKEGMEKFKKADVLIIDTAGRHKEEKGLLEEMKQIKEITNPDEIILVIDGTIGQQAGIQAKAFKEAVGE
IGSIIVTKLDGSAKGGGALSAVAETKAPIKFIGIGEGIDDLEPFDPKKFISRLLGMGDLESLLEKAEDMVDEKTEESIDA
IMRGKFTLNELMTQLEAIENMGSMKKILSMIPGFGGAMPKELSHLTEAKIKKYKVIISSMTKEERENPKIIKASRIRRIA
RGSGTTENDVREVLRYYETTKNAIDKLRKGKMLRIGGPLGQIMRQLMFKEG

Sequences:

>Translated_451_residues
MLDKLGENLNKALNKLKAAAFVDKKLIKEVIKDIQRALIQADVNVKLVLKMSKEIERRALEEKTPKGLSKKEHIIKIVYE
ELVKLLGEEAKKLELNPKKQNVILLVGIQGSGKTTTAAKLARYIQKRGLKPALIAADTYRPAAYEQLKQLAEKIHVPIYG
DETRTKSPVDIVKEGMEKFKKADVLIIDTAGRHKEEKGLLEEMKQIKEITNPDEIILVIDGTIGQQAGIQAKAFKEAVGE
IGSIIVTKLDGSAKGGGALSAVAETKAPIKFIGIGEGIDDLEPFDPKKFISRLLGMGDLESLLEKAEDMVDEKTEESIDA
IMRGKFTLNELMTQLEAIENMGSMKKILSMIPGFGGAMPKELSHLTEAKIKKYKVIISSMTKEERENPKIIKASRIRRIA
RGSGTTENDVREVLRYYETTKNAIDKLRKGKMLRIGGPLGQIMRQLMFKEG
>Mature_451_residues
MLDKLGENLNKALNKLKAAAFVDKKLIKEVIKDIQRALIQADVNVKLVLKMSKEIERRALEEKTPKGLSKKEHIIKIVYE
ELVKLLGEEAKKLELNPKKQNVILLVGIQGSGKTTTAAKLARYIQKRGLKPALIAADTYRPAAYEQLKQLAEKIHVPIYG
DETRTKSPVDIVKEGMEKFKKADVLIIDTAGRHKEEKGLLEEMKQIKEITNPDEIILVIDGTIGQQAGIQAKAFKEAVGE
IGSIIVTKLDGSAKGGGALSAVAETKAPIKFIGIGEGIDDLEPFDPKKFISRLLGMGDLESLLEKAEDMVDEKTEESIDA
IMRGKFTLNELMTQLEAIENMGSMKKILSMIPGFGGAMPKELSHLTEAKIKKYKVIISSMTKEERENPKIIKASRIRRIA
RGSGTTENDVREVLRYYETTKNAIDKLRKGKMLRIGGPLGQIMRQLMFKEG

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=453, Percent_Identity=43.7086092715232, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI226371618, Length=401, Percent_Identity=45.6359102244389, Blast_Score=328, Evalue=9e-90,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=54.0880503144654, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=23.2558139534884, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=23.2558139534884, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788963, Length=423, Percent_Identity=37.3522458628842, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=37.9699248120301, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=38.6206896551724, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=28.3720930232558, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325345, Length=428, Percent_Identity=42.7570093457944, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6320498, Length=317, Percent_Identity=25.8675078864353, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17647949, Length=435, Percent_Identity=41.1494252873563, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24641198, Length=217, Percent_Identity=25.3456221198157, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_METJA (Q57565)

Other databases:

- EMBL:   L77117
- PIR:   E64312
- RefSeq:   NP_247065.1
- PDB:   2V3C
- PDBsum:   2V3C
- ProteinModelPortal:   Q57565
- SMR:   Q57565
- DIP:   DIP-46442N
- GeneID:   1450940
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0101
- NMPDR:   fig|243232.1.peg.102
- TIGR:   MJ0101
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- ProtClustDB:   PRK00771
- BioCyc:   MJAN243232:MJ_0101-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 50125; Mature: 50125

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKLGENLNKALNKLKAAAFVDKKLIKEVIKDIQRALIQADVNVKLVLKMSKEIERRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
EEKTPKGLSKKEHIIKIVYEELVKLLGEEAKKLELNPKKQNVILLVGIQGSGKTTTAAKL
HHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHH
ARYIQKRGLKPALIAADTYRPAAYEQLKQLAEKIHVPIYGDETRTKSPVDIVKEGMEKFK
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
KADVLIIDTAGRHKEEKGLLEEMKQIKEITNPDEIILVIDGTIGQQAGIQAKAFKEAVGE
HCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
IGSIIVTKLDGSAKGGGALSAVAETKAPIKFIGIGEGIDDLEPFDPKKFISRLLGMGDLE
HHHEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHH
SLLEKAEDMVDEKTEESIDAIMRGKFTLNELMTQLEAIENMGSMKKILSMIPGFGGAMPK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ELSHLTEAKIKKYKVIISSMTKEERENPKIIKASRIRRIARGSGTTENDVREVLRYYETT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KNAIDKLRKGKMLRIGGPLGQIMRQLMFKEG
HHHHHHHHCCCEEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDKLGENLNKALNKLKAAAFVDKKLIKEVIKDIQRALIQADVNVKLVLKMSKEIERRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
EEKTPKGLSKKEHIIKIVYEELVKLLGEEAKKLELNPKKQNVILLVGIQGSGKTTTAAKL
HHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCEEEEEEECCCCCCHHHHHH
ARYIQKRGLKPALIAADTYRPAAYEQLKQLAEKIHVPIYGDETRTKSPVDIVKEGMEKFK
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
KADVLIIDTAGRHKEEKGLLEEMKQIKEITNPDEIILVIDGTIGQQAGIQAKAFKEAVGE
HCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
IGSIIVTKLDGSAKGGGALSAVAETKAPIKFIGIGEGIDDLEPFDPKKFISRLLGMGDLE
HHHEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHH
SLLEKAEDMVDEKTEESIDAIMRGKFTLNELMTQLEAIENMGSMKKILSMIPGFGGAMPK
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ELSHLTEAKIKKYKVIISSMTKEERENPKIIKASRIRRIARGSGTTENDVREVLRYYETT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KNAIDKLRKGKMLRIGGPLGQIMRQLMFKEG
HHHHHHHHCCCEEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087