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The map label for this gene is xapA [C]

Identifier: 15668231

GI number: 15668231

Start: 59467

End: 60225

Strand: Direct

Name: xapA [C]

Synonym: MJ0060

Alternate gene names: 15668231

Gene position: 59467-60225 (Clockwise)

Preceding gene: 15668230

Following gene: 15668232

Centisome position: 3.57

GC content: 32.02

Gene sequence:

>759_bases
GTGATTGGTATAATAGGAGGGACAGGAATAGCTGAAATATTAAAAGGAGACAAAGAAGAGATTATAAATACAAAATATGG
GAAAGCAAGAGTTATAATTGATAAAGAAAACGAAGTAGTTTTGTTATTTAGGCATGGAGTAAGACATAACATCCCACCAC
ATAAAATAAACTATAGGGCTAACATCTACGCTTTAAAAAAGTTGGGAGTTGAAAGAATATTGGCTATAAATTCAGTTGGT
TCATTAAAAGAAGATTTAAAGCCTGGAATGTTTTTTGTTCCAAATGATTTTATAGAATTTACAAAGAAGAGAGAAGAGAC
GTTTTACGATGAAGGAAAAGTTGTTCATATAGATATGACAGACCCTTACTGTCCAGAGTTGAGAAATATTTTAAAATCAA
TATTAGATAAAAATAACTTCTCTTATGGAGAAGGCGTTTATGTTTGCACTGAAGGACCGAGATTTGAAACAAAAAAAGAG
ATAGCCATATACAAAAACTGGGGGGATGTTGTAGGAATGACTGGATATCCTGAAGTTGTTTTAGCAAGGGAGTTGGAGAT
GTGCTATGTCTCTCTATGCAACATAACAAACTATGCCTGTGGAATATCAAAAAATATTTTAACAGTTGATGAAGTTTTGG
AAAAAATAAAAGAGATGGAAAATAAAATTTTGAAAGTTGTTGAGGACTTTATAAATTATGGCTTTGGAGAGAGAAAGTGT
ATCTGCAAAGATGCTTTGAAACATGCTGTTATTGGGTAA

Upstream 100 bases:

>100_bases
TTTATCAGATGGGTTTTAAATAAAACATAGAAAATTATTTTAAAGTTATTAAATAAAACTTAGTTTATTTATTTTTAATC
ATGTTATTTTTGGTGATAGT

Downstream 100 bases:

>100_bases
ATTATAAAACTAAAATCCTTTAATTTACACCTCCGAGCGTAAGCGAGGAGGTGTTGGGGTATCCCAATAGGGTTTCCCTA
TGGGCTTTAAAACATGCTAT

Product: methylthioadenosine phosphorylase MtaP

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRANIYALKKLGVERILAINSVG
SLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMTDPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKE
IAIYKNWGDVVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKC
ICKDALKHAVIG

Sequences:

>Translated_252_residues
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRANIYALKKLGVERILAINSVG
SLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMTDPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKE
IAIYKNWGDVVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKC
ICKDALKHAVIG
>Mature_252_residues
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRANIYALKKLGVERILAINSVG
SLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMTDPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKE
IAIYKNWGDVVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKC
ICKDALKHAVIG

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family

Homologues:

Organism=Homo sapiens, GI47132622, Length=235, Percent_Identity=40.8510638297872, Blast_Score=172, Evalue=3e-43,
Organism=Escherichia coli, GI1788746, Length=173, Percent_Identity=28.3236994219653, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980569, Length=226, Percent_Identity=36.7256637168142, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6323045, Length=284, Percent_Identity=30.2816901408451, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=35.1648351648352, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221459247, Length=240, Percent_Identity=36.6666666666667, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y060_METJA (Q60367)

Other databases:

- EMBL:   L77117
- PIR:   D64307
- RefSeq:   NP_247024.1
- ProteinModelPortal:   Q60367
- SMR:   Q60367
- GeneID:   1450899
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0060
- NMPDR:   fig|243232.1.peg.61
- TIGR:   MJ0060
- HOGENOM:   HBG286690
- OMA:   LLFRHGA
- ProtClustDB:   CLSK876055
- BioCyc:   MJAN243232:MJ_0060-MONOMER
- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099
- PANTHER:   PTHR11904
- TIGRFAMs:   TIGR01694

Pfam domain/function: PF01048 PNP_UDP_1

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28665; Mature: 28665

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRA
CEEEECCCCHHHHHCCCHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEECEE
NIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMT
HHHHHHHHCHHHHHHHHCHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEECC
DPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKEIAIYKNWGDVVGMTGYPEVV
CCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEECCCCCCHHH
LARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKC
HHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ICKDALKHAVIG
HHHHHHHHHCCC
>Mature Secondary Structure
MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRA
CEEEECCCCHHHHHCCCHHHHCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEECEE
NIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMT
HHHHHHHHCHHHHHHHHCHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEEECC
DPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKEIAIYKNWGDVVGMTGYPEVV
CCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCEECCCCCCHHH
LARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKC
HHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ICKDALKHAVIG
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087