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Identifier: 15646177

GI number: 15646177

Start: 1651213

End: 1651707

Strand: Reverse

Name: Not Available

Synonym: HP1570

Alternate gene names: 15646177

Gene position: 1651707-1651213 (Counterclockwise)

Preceding gene: 15646178

Following gene: 15646176

Centisome position: 99.03

GC content: 41.01

Gene sequence:

>495_bases
ATGATTAAGTTATTGCTTTTAGATGTGGATGGCACGCTCACAGACGGATCGTTGTATTTTGATGAAAATTTTCACGAAAT
CAAGGCTTTTAATGTCAAAGACGGGCTTGGCATGACGCTATGGCAAAAATTAGGCAAAAAAATCGCTATCATTACAGGAA
GAACTTCAATCATGGTGAAAAAACGCATGGAGAGTTTGGGCGTTCAGTTTGTTTTTATGGGCGTTGAAAATAAAAACACC
GTTATAGAGCGGCTCAAAAAAGACTTGCAATTGAGCGCGCAAGAAATCGCATGCGTGGGCGATGATTATAACGATTTAGG
CATGTTTAAGGCATGTGCTTTGAGTTTCGCCCCTTTTGATGCGCACCCCTTGCTTAAAAGTAAGGCTTATAAAGTGTTGC
AAAATTCAGGGGGCAAGGGGGCTGTTAGGGAAGCGATTGATTATCTTTTAACATTAGAAGGCTTGCAAGATGAAGCGCTC
AAGCTTTACCTCTAA

Upstream 100 bases:

>100_bases
AAGACGATTTGTATAAAGTTTTAGTTCAAGGGTTTCAAAGCGAAGAAGAGGCTAGGGATTTTATGAAAAAATACAACCAG
AATGCGGTTTTAACGAGAGA

Downstream 100 bases:

>100_bases
TAGCGTTTTAAACTTTTTTGTAGTTTTGTCTTTCATTACGATAGGATTAGTGTTTTTCTTTTTGCGTTCCCAACCCACTA
GCGTAGTTTCTAAAGAAAAT

Product: hypothetical protein

Products: NA

Alternate protein names: KDO 8-P phosphatase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIKLLLLDVDGTLTDGSLYFDENFHEIKAFNVKDGLGMTLWQKLGKKIAIITGRTSIMVKKRMESLGVQFVFMGVENKNT
VIERLKKDLQLSAQEIACVGDDYNDLGMFKACALSFAPFDAHPLLKSKAYKVLQNSGGKGAVREAIDYLLTLEGLQDEAL
KLYL

Sequences:

>Translated_164_residues
MIKLLLLDVDGTLTDGSLYFDENFHEIKAFNVKDGLGMTLWQKLGKKIAIITGRTSIMVKKRMESLGVQFVFMGVENKNT
VIERLKKDLQLSAQEIACVGDDYNDLGMFKACALSFAPFDAHPLLKSKAYKVLQNSGGKGAVREAIDYLLTLEGLQDEAL
KLYL
>Mature_164_residues
MIKLLLLDVDGTLTDGSLYFDENFHEIKAFNVKDGLGMTLWQKLGKKIAIITGRTSIMVKKRMESLGVQFVFMGVENKNT
VIERLKKDLQLSAQEIACVGDDYNDLGMFKACALSFAPFDAHPLLKSKAYKVLQNSGGKGAVREAIDYLLTLEGLQDEAL
KLYL

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate [H]

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=152, Percent_Identity=30.9210526315789, Blast_Score=80, Evalue=8e-16,
Organism=Escherichia coli, GI2367202, Length=158, Percent_Identity=43.0379746835443, Blast_Score=124, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.45 [H]

Molecular weight: Translated: 18268; Mature: 18268

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLLLLDVDGTLTDGSLYFDENFHEIKAFNVKDGLGMTLWQKLGKKIAIITGRTSIMVK
CEEEEEEECCCCEECCEEEECCCCCEEEEECCCCCCCHHHHHHCCCEEEEEECCHHHHHH
KRMESLGVQFVFMGVENKNTVIERLKKDLQLSAQEIACVGDDYNDLGMFKACALSFAPFD
HHHHHCCEEEEEEEECCCHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHCCCCC
AHPLLKSKAYKVLQNSGGKGAVREAIDYLLTLEGLQDEALKLYL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MIKLLLLDVDGTLTDGSLYFDENFHEIKAFNVKDGLGMTLWQKLGKKIAIITGRTSIMVK
CEEEEEEECCCCEECCEEEECCCCCEEEEECCCCCCCHHHHHHCCCEEEEEECCHHHHHH
KRMESLGVQFVFMGVENKNTVIERLKKDLQLSAQEIACVGDDYNDLGMFKACALSFAPFD
HHHHHCCEEEEEEEECCCHHHHHHHHHHHHCCHHHEEEECCCCCHHHHHHHHHHHCCCCC
AHPLLKSKAYKVLQNSGGKGAVREAIDYLLTLEGLQDEALKLYL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]