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Identifier: 15646087

GI number: 15646087

Start: 1549611

End: 1551659

Strand: Reverse

Name: Not Available

Synonym: HP1478

Alternate gene names: 15646087

Gene position: 1551659-1549611 (Counterclockwise)

Preceding gene: 15646088

Following gene: 15646086

Centisome position: 93.03

GC content: 40.21

Gene sequence:

>2049_bases
ATGATGGATTTTGAAAAAAGCATTTTAGACCATTTAAACGGAGCGCAAAAAATCGCTGCAAGCCACATTCAAGGGCCATT
GCTCATTTTAGCGGGAGCTGGGAGCGGTAAGACTAAGACTTTAACGAGCCGTTTAGCGTATTTGATTGGCGTTTGTGGCG
TGCCTAGCGAGAACACTTTAACGCTCACTTTCACCAATAAAGCGAGTAAAGAAATGCAAGAAAGGGCTTTGAAATTGTTG
AAAAACCAAGCCCTTATCCCCCCCTTGCTTTGCACTTTCCATCGTTTTGGTTTGCTGTTTTTAAGGCAACACATGAATCT
TTTAAAAAGGGCATGCGATTTTTCGGTATTAGATAGCGATGAAGTCAAAACGCTGTGCAAACAGCTCAAAATTTCAAACT
TTAGAGCCAGTATTTCTCAAATCAAAAACGGCATGATGGATTTGAGCATGCAAGATAGCGAATGCTATAAAGCGTATGAG
CTTTATCAAAACGCGCTCAAAAAAGACAATTTAGTGGATTTTGACGATTTGCTTTTTTTAAGCCTTAAGATTTTACAAGA
TAATGAAACCATCGCCAAAGAGACTAGCGAGCGCTACCACTACATTATGGTAGATGAGTATCAAGACACGAACGCCTTGC
AATTGGAGTTTTTAAAAAAATTGAGTTTCACGCACCATAATTTGTGCGTGGTGGGCGATGACGATCAGAGCATTTATGGG
TTTAGGGGGGCTGATATTTCTAACATTTTAAATTTTTCCAAGCATTTTAAAGGGGCTAAAATAGTGAAATTAGAGACCAA
CTACCGCTCTAGCGCTGAAATTTTAGCGTGCGCTAATTCTCTCATCAGCCACAACCAACACCGCCATATTAAAACGCTTC
AAAGTTTCAAAGGCTCGCATAAAAGCGTGGTTTGTAAAGAATATTTGACGCAAAAAGAAGAGAGCCTGGATGTGGCTTAT
CAAATCAAAGCCCTTTTAAAGAAGGGCGAGAATTTAGAAAATATCGCTATTTTGTATCGCTTAAACGGGCTTAGCCGCAG
CATTGAAGAGAGCTTGAACGCTTTGAATATCCCTTATAGGCTCATTGGGGCGCTGAGTTTCTATGAAAGAGCCGAGATTA
AAGACGCTTTGGCGTTCATGCATTTAGTGGCTAAAAAAGACGATCGCTTTTTTATTAAGCGCGTTTTAAACAAGCCCCCA
AGAGGTCTTGGCAAGATCACTCAAGAATGGATTTTTTCTCTTTTAGATGAAGAGGGTTTGAATTTAGAAGAGGCGCTAAA
ACTTGGGGCGTTTAAAGACAAATTAAACCCTAAAAACGAATACGCTTTGAAACAATTTATCGCTATGATAGGGCGTTTGA
GGGAGGCTTTTGAAATTTCAGTAGAGGAGTTTTGCTCTCGGTTTTTAGAAGAGACTAACCTTTTAAAAAGCTATGAAAAA
GAAGACAATTACGAAGAAAGAGAGGGCTTTGTTAAAGAGCTTTTAACCTTAGTGAAAGAATATTTTAAAACTAACCCCAC
GCATTCTTTACTGGATTTTTTGAATGAAAGCGTGCTGGATGCCCATAATACAGAAAACGCGCAAAAAGTGAGTTGCATGA
GCGTGCATATGAGTAAGGGATTAGAGTTTAAGCATGTGTTTGTGATCGGGTTAGAAGAAGGGTTTTTCCCGCATAGGGGG
TTCAATCAGGAAAGCGATTTAGAAGAAGAAAGGCGCTTGGCTTACGTAGCGATCACTAGGGCTAAAGAAGAATTGCAGCT
CTCTTATGTGAAAGAGCGTTCGTATTTTGGGAGGAAAATTTCTTGCTCGCCCTCTGTGTTTTTAGAGGAAGCCCAGTTGC
TCAATCAAGACAACCCCCCTAAACAGGATCATCAAAAAGACGCGCCCATTAAAGTGGGGGACTTGATTAGGCATAAGATT
TTTGGCACTGGGAGGGTTTTAGGCGTAGAAAAAGGCTTGAGCGGTTTGTGCTTGAAAATCAATTGCGGAGGGAATGTCTA
TGATAAAATCTCAGAAAAATTTGTAGAAAAAGTGGATAACGGGTTTTGA

Upstream 100 bases:

>100_bases
TTAAAACCTCTGATTTTTCTTCGCCTTATTTTGATTTTGAAATTGATGCGAACCTTTTAAAAGAGCGTTTGGACCAAGAA
AAAGAAGGCGAGTTTTTAGA

Downstream 100 bases:

>100_bases
AAATTTTAATCCTTTTTTTTATCTGTTTAAACGCATTGTTCGCCCTAGATTCAAACGCACTTAAAGCAGAGATTAAAGAA
GTTTACCTTAAAGAATACAA

Product: DNA helicase II (uvrD)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MMDFEKSILDHLNGAQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTLTLTFTNKASKEMQERALKLL
KNQALIPPLLCTFHRFGLLFLRQHMNLLKRACDFSVLDSDEVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYE
LYQNALKKDNLVDFDDLLFLSLKILQDNETIAKETSERYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
FRGADISNILNFSKHFKGAKIVKLETNYRSSAEILACANSLISHNQHRHIKTLQSFKGSHKSVVCKEYLTQKEESLDVAY
QIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYRLIGALSFYERAEIKDALAFMHLVAKKDDRFFIKRVLNKPP
RGLGKITQEWIFSLLDEEGLNLEEALKLGAFKDKLNPKNEYALKQFIAMIGRLREAFEISVEEFCSRFLEETNLLKSYEK
EDNYEEREGFVKELLTLVKEYFKTNPTHSLLDFLNESVLDAHNTENAQKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRG
FNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGRKISCSPSVFLEEAQLLNQDNPPKQDHQKDAPIKVGDLIRHKI
FGTGRVLGVEKGLSGLCLKINCGGNVYDKISEKFVEKVDNGF

Sequences:

>Translated_682_residues
MMDFEKSILDHLNGAQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTLTLTFTNKASKEMQERALKLL
KNQALIPPLLCTFHRFGLLFLRQHMNLLKRACDFSVLDSDEVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYE
LYQNALKKDNLVDFDDLLFLSLKILQDNETIAKETSERYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
FRGADISNILNFSKHFKGAKIVKLETNYRSSAEILACANSLISHNQHRHIKTLQSFKGSHKSVVCKEYLTQKEESLDVAY
QIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYRLIGALSFYERAEIKDALAFMHLVAKKDDRFFIKRVLNKPP
RGLGKITQEWIFSLLDEEGLNLEEALKLGAFKDKLNPKNEYALKQFIAMIGRLREAFEISVEEFCSRFLEETNLLKSYEK
EDNYEEREGFVKELLTLVKEYFKTNPTHSLLDFLNESVLDAHNTENAQKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRG
FNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGRKISCSPSVFLEEAQLLNQDNPPKQDHQKDAPIKVGDLIRHKI
FGTGRVLGVEKGLSGLCLKINCGGNVYDKISEKFVEKVDNGF
>Mature_682_residues
MMDFEKSILDHLNGAQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTLTLTFTNKASKEMQERALKLL
KNQALIPPLLCTFHRFGLLFLRQHMNLLKRACDFSVLDSDEVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYE
LYQNALKKDNLVDFDDLLFLSLKILQDNETIAKETSERYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
FRGADISNILNFSKHFKGAKIVKLETNYRSSAEILACANSLISHNQHRHIKTLQSFKGSHKSVVCKEYLTQKEESLDVAY
QIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYRLIGALSFYERAEIKDALAFMHLVAKKDDRFFIKRVLNKPP
RGLGKITQEWIFSLLDEEGLNLEEALKLGAFKDKLNPKNEYALKQFIAMIGRLREAFEISVEEFCSRFLEETNLLKSYEK
EDNYEEREGFVKELLTLVKEYFKTNPTHSLLDFLNESVLDAHNTENAQKVSCMSVHMSKGLEFKHVFVIGLEEGFFPHRG
FNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGRKISCSPSVFLEEAQLLNQDNPPKQDHQKDAPIKVGDLIRHKI
FGTGRVLGVEKGLSGLCLKINCGGNVYDKISEKFVEKVDNGF

Specific function: Essential helicase. May act as a helicase in plasmid pT181 replication [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=689, Percent_Identity=33.0914368650218, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI48994965, Length=643, Percent_Identity=34.5256609642302, Blast_Score=317, Evalue=2e-87,
Organism=Escherichia coli, GI1787196, Length=146, Percent_Identity=32.1917808219178, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322369, Length=464, Percent_Identity=29.9568965517241, Blast_Score=158, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324477, Length=363, Percent_Identity=25.8953168044077, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77849; Mature: 77849

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDFEKSILDHLNGAQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTL
CCCHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
TLTFTNKASKEMQERALKLLKNQALIPPLLCTFHRFGLLFLRQHMNLLKRACDFSVLDSD
EEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
EVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYELYQNALKKDNLVDFDDLLFL
HHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SLKILQDNETIAKETSERYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
HHHHHCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCC
FRGADISNILNFSKHFKGAKIVKLETNYRSSAEILACANSLISHNQHRHIKTLQSFKGSH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
KSVVCKEYLTQKEESLDVAYQIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYR
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHCCCCHH
LIGALSFYERAEIKDALAFMHLVAKKDDRFFIKRVLNKPPRGLGKITQEWIFSLLDEEGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
NLEEALKLGAFKDKLNPKNEYALKQFIAMIGRLREAFEISVEEFCSRFLEETNLLKSYEK
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNYEEREGFVKELLTLVKEYFKTNPTHSLLDFLNESVLDAHNTENAQKVSCMSVHMSKG
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
LEFKHVFVIGLEEGFFPHRGFNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGRKI
CCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCEE
SCSPSVFLEEAQLLNQDNPPKQDHQKDAPIKVGDLIRHKIFGTGRVLGVEKGLSGLCLKI
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEE
NCGGNVYDKISEKFVEKVDNGF
ECCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMDFEKSILDHLNGAQKIAASHIQGPLLILAGAGSGKTKTLTSRLAYLIGVCGVPSENTL
CCCHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
TLTFTNKASKEMQERALKLLKNQALIPPLLCTFHRFGLLFLRQHMNLLKRACDFSVLDSD
EEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
EVKTLCKQLKISNFRASISQIKNGMMDLSMQDSECYKAYELYQNALKKDNLVDFDDLLFL
HHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SLKILQDNETIAKETSERYHYIMVDEYQDTNALQLEFLKKLSFTHHNLCVVGDDDQSIYG
HHHHHCCCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCC
FRGADISNILNFSKHFKGAKIVKLETNYRSSAEILACANSLISHNQHRHIKTLQSFKGSH
CCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
KSVVCKEYLTQKEESLDVAYQIKALLKKGENLENIAILYRLNGLSRSIEESLNALNIPYR
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHCCCCHH
LIGALSFYERAEIKDALAFMHLVAKKDDRFFIKRVLNKPPRGLGKITQEWIFSLLDEEGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
NLEEALKLGAFKDKLNPKNEYALKQFIAMIGRLREAFEISVEEFCSRFLEETNLLKSYEK
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNYEEREGFVKELLTLVKEYFKTNPTHSLLDFLNESVLDAHNTENAQKVSCMSVHMSKG
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
LEFKHVFVIGLEEGFFPHRGFNQESDLEEERRLAYVAITRAKEELQLSYVKERSYFGRKI
CCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHHHHCCCEE
SCSPSVFLEEAQLLNQDNPPKQDHQKDAPIKVGDLIRHKIFGTGRVLGVEKGLSGLCLKI
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEEEE
NCGGNVYDKISEKFVEKVDNGF
ECCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232203 [H]