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The map label for this gene is tmk

Identifier: 15646083

GI number: 15646083

Start: 1547335

End: 1547910

Strand: Reverse

Name: tmk

Synonym: HP1474

Alternate gene names: 15646083

Gene position: 1547910-1547335 (Counterclockwise)

Preceding gene: 15646084

Following gene: 15646082

Centisome position: 92.81

GC content: 39.93

Gene sequence:

>576_bases
ATGTATGTGGTGTTAGAAGGCGTTGATGGCGCGGGCAAAAGCACTCAAGTAGAATTATTAAAAGACCGGTTTAAAAACGC
CCTTTTTACCAAAGAGCCAGGGGGGACGAGAATGGGCGAGAGTTTAAGGCGTATCGCTTTGAATGAAAACATTAGCGAAT
TGGCTAGAGCGTTTTTATTCTTAAGCGATAGGGCTGAGCATACAGAAAGCGTGATAAAACCGGCATTGAAAGAAAAAAAG
CTCATCATTAGCGACAGGAGCTTGATCTCTGGCATGGCTTATAGCCAATTTTCAAGCTTAGAATTAAACCTGCTTGCCAC
CCAAAGCGTCTTGCCTGCAAAAATCATTCTTTTACTCATAGACAAAGAGGGCTTAAAACAGCGCTTAAGCCTTAAAAGTT
TAGATAAAATAGAAAACCAAGGCATAGAAAAATTACTTCATATCCAGCAAAAGCTCAAAACCCACGCTTATGCGTTACAA
GAAAAATTTGGGTGCGAAGTTTTGGAATTAGACGCTAAAGAAAGCGTTAAAAACTTGCACGAAAAAATCGCCGCTTTTAT
AAAATGCGCTGTTTAA

Upstream 100 bases:

>100_bases
TTCATAAGCTCTTCTATCGTGCGATCCATTATCGCGCATAAGGGCGATGCGAGCCATTTAGTGCCTAAAGAAATTTATCC
TTTGATTTCAAAGGCTTAAA

Downstream 100 bases:

>100_bases
CCTGTTTGAAGCTTTCTTTTAAGCCTCTTTGCCCAAATTGCTTGAACGATTTGCCCTTAAGCTTAAAGGTAAGGGTTTTA
GAGGGCGTGAGCGTGTATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLFLSDRAEHTESVIKPALKEKK
LIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLIDKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQ
EKFGCEVLELDAKESVKNLHEKIAAFIKCAV

Sequences:

>Translated_191_residues
MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLFLSDRAEHTESVIKPALKEKK
LIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLIDKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQ
EKFGCEVLELDAKESVKNLHEKIAAFIKCAV
>Mature_191_residues
MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLFLSDRAEHTESVIKPALKEKK
LIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLIDKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQ
EKFGCEVLELDAKESVKNLHEKIAAFIKCAV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=161, Percent_Identity=34.7826086956522, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 21363; Mature: 21363

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLF
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LSDRAEHTESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLI
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEE
DKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQEKFGCEVLELDAKESVKNLH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHH
EKIAAFIKCAV
HHHHHHHHHCC
>Mature Secondary Structure
MYVVLEGVDGAGKSTQVELLKDRFKNALFTKEPGGTRMGESLRRIALNENISELARAFLF
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LSDRAEHTESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPAKIILLLI
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEE
DKEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQEKFGCEVLELDAKESVKNLH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHH
EKIAAFIKCAV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA