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Identifier: 15646077

GI number: 15646077

Start: 1538762

End: 1539784

Strand: Reverse

Name: Not Available

Synonym: HP1468

Alternate gene names: 15646077

Gene position: 1539784-1538762 (Counterclockwise)

Preceding gene: 15646078

Following gene: 15646075

Centisome position: 92.32

GC content: 45.45

Gene sequence:

>1023_bases
ATGGCAAATTTAGAAAATTTAGACTGGAAAAATTTAGGCTTTAGCTACATTAAAACGGATTTTCGCTTCATCGCCACTTA
TAAAAACGGCTCTTGGTCGCAAGGCGGATTGGTGAGCGAAAACATGTTACAACTCAGCGAAGGCTCGCCGGTCTTGCACT
ACGGGCAGGCTTGTTTTGAAGGCTTGAAGGCTTACCGCTCTCAAAAGGGGAAAGCTTTACTCTTTCGCCCTTTAGAAAAC
GCCAAACGCTTGCAAACTTCATGCGAAAGACTGCTCATGCCCAAAGTGAGCGAAGAGCTGTTTTTAAGGGCATGCGCTGA
AGTGGTGAAAGCGAATCAAAAATGGCTCGCTCCTTATAAAAGCGGGGCGAGTTTGTATTTGCGCCCTTTTGTCATAGGCG
TAGGGGATAATTTGGGGGTGAAGCCGGCTAATGAATACCTTTTTATCGTGTTTTGTGCGCCTGTGGGGGCGTATTTTAAG
GGGGGTATAGAAAAAGGGGGGGCTAGGTTTATCACTACGATTTTTGATAGGGCCGCGCCTAAAGGCACCGGTGGGGTGAA
AGTGGGAGGGAATTACGCTGCAAGCCTGTTAGCCCATAAAATGGCCACAGAGCAAGGCTATGATGATTGCATTTATTTAG
ACCCTACTACGCACACTAAAATTGAAGAAGTGGGGGCGGCGAATTTTTTTGGCATCACGCATGATGATGCCTTTATCACC
CCGCATTCGCCAAGCATTCTGCCAAGCATTACCAAAAAAAGCTTGATGGTTTTGGCTAAAGAATATTTGAACCTCAAAGT
AGAAGAGAGGGAAATCCTAATGGATGAGTTGGATGCGTTTAAAGAAGCTGGAGCGTGCGGGACAGCTGCGATCATTACGC
CCATTAAAGAAATCGTGCACAACAACAAGTCTTATTTTTTTGAAGCGCCGGGCCATATTACTAAACGACTCTATGATTTG
CTTTTATCCATCCAACAAGGCGAACAAGAAGCCCCCAAAGATTGGATTTTTGAAGTTGGCTAA

Upstream 100 bases:

>100_bases
TGTGCGTAGAGTTTATGCGTTTCAAATCAGTTACTTGAGGGATTTTTAACCCCTTTTTAGATACAATCACGCCTGAAACT
ATCCATTTAAAGGTGTGAAA

Downstream 100 bases:

>100_bases
AAGGTTAAAATTTATAGCTGTATGCCGCATAAAATAAGGGCGAAGTCTCAAAGCGTTTAGAGCTAGAAAGCAATCTGGCG
GTGGGTAAGATTTTAAACCC

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MANLENLDWKNLGFSYIKTDFRFIATYKNGSWSQGGLVSENMLQLSEGSPVLHYGQACFEGLKAYRSQKGKALLFRPLEN
AKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYKSGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFK
GGIEKGGARFITTIFDRAAPKGTGGVKVGGNYAASLLAHKMATEQGYDDCIYLDPTTHTKIEEVGAANFFGITHDDAFIT
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIVHNNKSYFFEAPGHITKRLYDL
LLSIQQGEQEAPKDWIFEVG

Sequences:

>Translated_340_residues
MANLENLDWKNLGFSYIKTDFRFIATYKNGSWSQGGLVSENMLQLSEGSPVLHYGQACFEGLKAYRSQKGKALLFRPLEN
AKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYKSGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFK
GGIEKGGARFITTIFDRAAPKGTGGVKVGGNYAASLLAHKMATEQGYDDCIYLDPTTHTKIEEVGAANFFGITHDDAFIT
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIVHNNKSYFFEAPGHITKRLYDL
LLSIQQGEQEAPKDWIFEVG
>Mature_339_residues
ANLENLDWKNLGFSYIKTDFRFIATYKNGSWSQGGLVSENMLQLSEGSPVLHYGQACFEGLKAYRSQKGKALLFRPLENA
KRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYKSGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFKG
GIEKGGARFITTIFDRAAPKGTGGVKVGGNYAASLLAHKMATEQGYDDCIYLDPTTHTKIEEVGAANFFGITHDDAFITP
HSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIVHNNKSYFFEAPGHITKRLYDLL
LSIQQGEQEAPKDWIFEVG

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI38176287, Length=346, Percent_Identity=32.6589595375723, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI296010904, Length=346, Percent_Identity=32.6589595375723, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI296010906, Length=346, Percent_Identity=32.6589595375723, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI50658084, Length=343, Percent_Identity=30.3206997084548, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI258614015, Length=296, Percent_Identity=31.0810810810811, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI296010902, Length=346, Percent_Identity=28.3236994219653, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI296010900, Length=346, Percent_Identity=28.3236994219653, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI48994963, Length=314, Percent_Identity=31.8471337579618, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17568601, Length=314, Percent_Identity=31.8471337579618, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17565728, Length=268, Percent_Identity=32.4626865671642, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322002, Length=307, Percent_Identity=32.8990228013029, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322608, Length=310, Percent_Identity=33.5483870967742, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24641779, Length=341, Percent_Identity=29.3255131964809, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 37642; Mature: 37510

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00770 AA_TRANSFER_CLASS_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLENLDWKNLGFSYIKTDFRFIATYKNGSWSQGGLVSENMLQLSEGSPVLHYGQACFE
CCCCCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHH
GLKAYRSQKGKALLFRPLENAKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYK
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFKGGIEKGGARFITTIFDRAAP
CCCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHCCC
KGTGGVKVGGNYAASLLAHKMATEQGYDDCIYLDPTTHTKIEEVGAANFFGITHDDAFIT
CCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCEEEEECCCCEEC
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIVH
CCCCCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NNKSYFFEAPGHITKRLYDLLLSIQQGEQEAPKDWIFEVG
CCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEECC
>Mature Secondary Structure 
ANLENLDWKNLGFSYIKTDFRFIATYKNGSWSQGGLVSENMLQLSEGSPVLHYGQACFE
CCCCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHH
GLKAYRSQKGKALLFRPLENAKRLQTSCERLLMPKVSEELFLRACAEVVKANQKWLAPYK
HHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
SGASLYLRPFVIGVGDNLGVKPANEYLFIVFCAPVGAYFKGGIEKGGARFITTIFDRAAP
CCCCEEEEEEEEECCCCCCCCCCCCEEEEEEECCHHHHHHCCCCCCCHHHHHHHHHHCCC
KGTGGVKVGGNYAASLLAHKMATEQGYDDCIYLDPTTHTKIEEVGAANFFGITHDDAFIT
CCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCEEEEECCCCEEC
PHSPSILPSITKKSLMVLAKEYLNLKVEEREILMDELDAFKEAGACGTAAIITPIKEIVH
CCCCCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
NNKSYFFEAPGHITKRLYDLLLSIQQGEQEAPKDWIFEVG
CCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]