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Identifier: 15645974

GI number: 15645974

Start: 1422915

End: 1424381

Strand: Reverse

Name: Not Available

Synonym: HP1362

Alternate gene names: 15645974

Gene position: 1424381-1422915 (Counterclockwise)

Preceding gene: 15645975

Following gene: 15645973

Centisome position: 85.4

GC content: 40.76

Gene sequence:

>1467_bases
ATGGATCATTTAAAGCATTTGCAGCAATTGCAAAACATTGAAAGGATCGTGCTTTCAGGCATTGTGTTGGCCAATCATAA
GATTGAAGAGGTCCATAGCGTTTTAGAGCCTAGCGATTTTTACTACCCGCCTAACGGCTTATTTTTTGAAATCGCTTTAA
AACTGCATGAAGAAGATTGCCCCATTGATGAGAATTTTATCCGCCAAAAAATGCCTAAAGACAAGCAGATCAAAGAAGAA
GATCTAGTCGCTATTTTTGCGGCAAGCCCCATAGATAATATTGAAGCCTATGTGGAAGAGATTAAAAACGCTTCCATTAA
ACGAAAACTTTTTGGCTTGGCTAACACCATTAGAGAGCAAGCCCTAGAAAGCGCGCAAAAATCCAGCGATATTTTAGGCG
CTGTGGAGCGAGAAGTCTATGCGTTATTGAATGGCAGCACCATAGAAGGCTTTAGGAATATTAAAGAAGTGCTTGAAAGC
GCAATGGATCTCATTACAGAAAACCAAAGAAAGGGGAGTTTGGAAGTTACTGGCATACCGACTGGCTTTGTCCAATTGGA
TAACTATACGAGCGGTTTCAATAAGGGGAGTTTAGTCATTATAGGGGCAAGGCCGTCTATGGGTAAAACTAGTTTGATGA
TGAACATGGTCTTAAGCGCGCTCAATGACGATAGGGGGGTAGCGGTTTTTAGTTTAGAAATGTCCGCAGAGCAACTCGCT
TTAAGGGCGTTATCGGATCTCACCTCTATTAACATGCATGATTTAGAAAGCGGGAGGCTTGATGATGATCAATGGGAAAA
TTTAGCCAAATGCTTTGATCACCTTTCGCAAAAAAAACTCTTTTTCTACGATAAAAGTTATGTGAGGATAGAGCAAATCC
GCTTGCAACTACGAAAGCTTAAATCCCAACACAAGGAATTGGGTATCGCTTTTATTGACTATTTGCAGCTCATGTCAGGG
AGTAAAGCCACTAAAGAGCGCCATGAGCAAATCGCTGAAATTTCAAGGGAGCTTAAAACTTTAGCCAGAGAATTAGAAAT
CCCTATCATAGCGTTAGTGCAACTCAACCGCAGCCTAGAAAACCGAGACGATAAACGGCCCATTCTTTCGGATATCAAAG
ACAGCGGGGGGATTGAACAAGACGCTGATATTGTTTTATTTTTATATAGAGGCTATATCTATCAAATGAGGGCTGAAGAC
AACAAAATAGACAAACTCAAAAAAGAAGGTAAAATTGAAGAGGCGCAAGAGTTGTACTTAAAAGTTAATGAAGAAAGGCG
TATCCACAAGCAAAATGGCAGCATTGAAGAGGCTGAAATCATTGTGGCTAAAAACAGGAATGGGGCTACAGGAACGGTTT
ATACGCGCTTTAACGCTCCTTTCACGCGCTATGAAGACATGCCCATAGATTCCCATTTAGAAGAAGGGCAAGAAACTAAA
GTGGATTATGATATAGTTACAACTTGA

Upstream 100 bases:

>100_bases
AGTTCAGCACACGCTCTAGCGAGTTTAGAATTTAAGAACAATTACGCTTTAACGCCCCTAGATTTGATAGAAAAGATCAA
ACAATTATAAAAGGATAAAA

Downstream 100 bases:

>100_bases
AAGACAAAACTTTTCAGGGGGCGTTTGAACTTCTTACGACCCCCAAAGAATACCTGGTGTGTGGGGTGTTTTTAAGCCTT
TTATTGGCGATTAACCTTTA

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDCPIDENFIRQKMPKDKQIKEE
DLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLES
AMDLITENQRKGSLEVTGIPTGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLA
LRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKLKSQHKELGIAFIDYLQLMSG
SKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAED
NKIDKLKKEGKIEEAQELYLKVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETK
VDYDIVTT

Sequences:

>Translated_488_residues
MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDCPIDENFIRQKMPKDKQIKEE
DLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLES
AMDLITENQRKGSLEVTGIPTGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLA
LRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKLKSQHKELGIAFIDYLQLMSG
SKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAED
NKIDKLKKEGKIEEAQELYLKVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETK
VDYDIVTT
>Mature_488_residues
MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDCPIDENFIRQKMPKDKQIKEE
DLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLES
AMDLITENQRKGSLEVTGIPTGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLA
LRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKLKSQHKELGIAFIDYLQLMSG
SKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAED
NKIDKLKKEGKIEEAQELYLKVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETK
VDYDIVTT

Specific function: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain

Homologues:

Organism=Escherichia coli, GI1790486, Length=466, Percent_Identity=33.0472103004292, Blast_Score=255, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAB_HELPY (O25916)

Other databases:

- EMBL:   AE000511
- PIR:   B64690
- RefSeq:   NP_208154.1
- PDB:   3GXV
- PDBsum:   3GXV
- ProteinModelPortal:   O25916
- SMR:   O25916
- DIP:   DIP-3388N
- MINT:   MINT-181617
- GeneID:   900325
- GenomeReviews:   AE000511_GR
- KEGG:   hpy:HP1362
- NMPDR:   fig|85962.1.peg.1350
- TIGR:   HP_1362
- HOGENOM:   HBG734566
- OMA:   DENFIRQ
- ProtClustDB:   PRK08506
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136
- Gene3D:   G3DSA:1.10.860.10
- TIGRFAMs:   TIGR00665

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C; SSF48024 DNA_helicase_DnaB-like_N

EC number: =3.6.4.12

Molecular weight: Translated: 55727; Mature: 55727

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS51199 SF4_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDC
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCCEEEEEEECCCCCC
PIDENFIRQKMPKDKQIKEEDLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQ
CCCHHHHHHHCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLESAMDLITENQRKGSLEVTGIP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
TGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLA
CCEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
LRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKL
HHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
KSQHKELGIAFIDYLQLMSGSKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
NRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAEDNKIDKLKKEGKIEEAQELYL
CCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHEEECCCCCHHHHHHHCCCHHHHHHHHH
KVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETK
HCCCHHHHHHCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCCC
VDYDIVTT
CCEEEECC
>Mature Secondary Structure
MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDC
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCCEEEEEEECCCCCC
PIDENFIRQKMPKDKQIKEEDLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQ
CCCHHHHHHHCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLESAMDLITENQRKGSLEVTGIP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
TGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLA
CCEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
LRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKL
HHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
KSQHKELGIAFIDYLQLMSGSKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
NRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAEDNKIDKLKKEGKIEEAQELYL
CCCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHEEECCCCCHHHHHHHCCCHHHHHHHHH
KVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETK
HCCCHHHHHHCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCCC
VDYDIVTT
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9252185