Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15645912

GI number: 15645912

Start: 1370598

End: 1371359

Strand: Reverse

Name: Not Available

Synonym: HP1299

Alternate gene names: 15645912

Gene position: 1371359-1370598 (Counterclockwise)

Preceding gene: 15645913

Following gene: 15645911

Centisome position: 82.22

GC content: 44.09

Gene sequence:

>762_bases
ATGGCAATCTCTATTAAAAGCCCAAAAGAAATCAAAGCTCTAAGAAAAGCCGGGGAATTAACCGCTCAAGCGTTAGCCCT
TTTAGAGCGAGAAGTAAGGCCTGGGGTTTCACTTTTAGAGCTGGATAAAATGGCTGAAGATTTTATCAAATCCTCTCATG
CCAGGCCTGCTTTTAAGGGGCTGTATGGATTTCCTAACTCTGTGTGCATGTCCTTAAATGAGGTGGTTATTCATGGCATT
CCTACGGATTATGTTTTACAAGAAGGGGATATTATAGGCTTGGATTTGGGGGTGGAGGTGGATGGCTATTATGGCGATTC
AGCCCTCACGCTTCCTATAGGTGCGATAAGCCCGCAAGATGAAAAATTGCTCGCTTGCTCTAAAGAGAGCTTGATGCATG
CCATTAATTCAATTAGAGTGGGCATGCATTTTAAAGAGTTGAGTCAGATTTTAGAGAGCACTATTACAGAAAGGGGCTTT
GTGCCTTTGAAAGGATTTTGCGGGCATGGCATTGGTAAAAAACCCCATGAAGAGCCAGAGATCCCCAACTACCTAGAAAA
AGGCGTCAAACCTAATAGCGGCCCTAAAATCAAAGAGGGCATGGTATTTTGCTTAGAGCCTATGGTGTGTCAAAAACAGG
GCGAGCCTAAAATACTAGCGGATAAGTGGAGCGTGGTTTCAGTGGATGGGCTTAACACAAGCCACCATGAGCATACTATC
GCCATAGTTGGCAATAAAGCAGTGATTCTTACGGAGCGTTAA

Upstream 100 bases:

>100_bases
CGGTGCTGATTGTGGTTCAAGTCGCTATTGACACCATGAAAAAGATTGAAGCGCAAATTTATATGAGCAAGTATAAAACT
TTAAGCGCGGTAGGCTTTTA

Downstream 100 bases:

>100_bases
TGGCAAGAGATGATGTTATAGAAGTGGATGGGAAAGTGATTGAGGCGTTGCCTAACGCTACTTTTAAGGTGGAGTTAGAC
AATAAGCATGTGGTGTTGTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGI
PTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAISPQDEKLLACSKESLMHAINSIRVGMHFKELSQILESTITERGF
VPLKGFCGHGIGKKPHEEPEIPNYLEKGVKPNSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
AIVGNKAVILTER

Sequences:

>Translated_253_residues
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGI
PTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAISPQDEKLLACSKESLMHAINSIRVGMHFKELSQILESTITERGF
VPLKGFCGHGIGKKPHEEPEIPNYLEKGVKPNSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
AIVGNKAVILTER
>Mature_252_residues
AISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKGLYGFPNSVCMSLNEVVIHGIP
TDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAISPQDEKLLACSKESLMHAINSIRVGMHFKELSQILESTITERGFV
PLKGFCGHGIGKKPHEEPEIPNYLEKGVKPNSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTIA
IVGNKAVILTER

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=32.6693227091633, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=33.8645418326693, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=38.4313725490196, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1788728, Length=209, Percent_Identity=24.8803827751196, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789275, Length=222, Percent_Identity=26.1261261261261, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=252, Percent_Identity=30.5555555555556, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=34.7826086956522, Blast_Score=149, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=33.7349397590361, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=30.2788844621514, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27577; Mature: 27446

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKG
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAISPQD
HCCCCHHHHHHHHHHEEECCCHHHEEECCCEEEEEECEEECCEECCCEEEEEECCCCCCC
EKLLACSKESLMHAINSIRVGMHFKELSQILESTITERGFVPLKGFCGHGIGKKPHEEPE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
IPNYLEKGVKPNSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
CCHHHHHCCCCCCCCCHHHCEEEEECCHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEE
AIVGNKAVILTER
EEECCEEEEEECC
>Mature Secondary Structure 
AISIKSPKEIKALRKAGELTAQALALLEREVRPGVSLLELDKMAEDFIKSSHARPAFKG
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LYGFPNSVCMSLNEVVIHGIPTDYVLQEGDIIGLDLGVEVDGYYGDSALTLPIGAISPQD
HCCCCHHHHHHHHHHEEECCCHHHEEECCCEEEEEECEEECCEECCCEEEEEECCCCCCC
EKLLACSKESLMHAINSIRVGMHFKELSQILESTITERGFVPLKGFCGHGIGKKPHEEPE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCC
IPNYLEKGVKPNSGPKIKEGMVFCLEPMVCQKQGEPKILADKWSVVSVDGLNTSHHEHTI
CCHHHHHCCCCCCCCCHHHCEEEEECCHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEE
AIVGNKAVILTER
EEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]