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Identifier: 15645894

GI number: 15645894

Start: 1356686

End: 1357270

Strand: Reverse

Name: Not Available

Synonym: HP1281

Alternate gene names: 15645894

Gene position: 1357270-1356686 (Counterclockwise)

Preceding gene: 15645895

Following gene: 15646202

Centisome position: 81.38

GC content: 38.12

Gene sequence:

>585_bases
ATGAAAATCTTTTTTATAGATAATTTTGATTCTTTCTCTTATAATTTGGTGTATGAATTAGAGTGTTTGGGTTATGAAGT
GGCCGTTTATCAAAACGATATTGATCCGAGTTATCTCATGGATTTGATGAATGAAGAATCAAAAACGCCTTTATTGTTCA
TTTCACCAGGACCTGGTAACCCTAATAGTTCAGGCAATCTTTTAAAAATCATTGCAATGGCTAAAAAGAAATTCCCCATT
TTAGGGATTTGTTTAGGCTTGCAAGCTTTAGCGCAAAGCTATGGGGCTAAAATCATAAGAAGTAAAGAAATCGTGCATGG
CAAAGCGACGGCCATCGCACTCAAAAAGCATGCCGTTTTTAAAGGTTTAGGGGAAAGCATGGTGGTGGGGCGTTACCATT
CTTTAATGGCAAGCGGGTTGCCTAAAAATTTAGAAGTGATCGCTGAGCATGACAATATCCCTATGGCTATTGTCAATGAA
GAAGATAAAATCTTAGCCTATCAATTCCACCCTGAAAGCATCATGACTTTACAAGGGAGGGCGTTGTTAGAGCAAAGCGT
GGGGTTTTTAGAAGGGTTATTATGA

Upstream 100 bases:

>100_bases
CAGGAGCCGGTATTGTGCTAGACAGCGTGCCACAAAACGAAGCGAATGAAACAAGAGCCAAAGCGCAAGCCCTTATTGAT
GCGATCAGGAAAACAAGCTT

Downstream 100 bases:

>100_bases
AAGAGATTTTAAACGCTCTGTATCATCAAAAAGATTTAAACGATGAAGAAGTCAAAAAGTTATTCACCCTTATTATCCAC
GAAAAAGTAAGCCCGGTGCA

Product: anthranilate synthase component II

Products: NA

Alternate protein names: Glutamine amido-transferase [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MKIFFIDNFDSFSYNLVYELECLGYEVAVYQNDIDPSYLMDLMNEESKTPLLFISPGPGNPNSSGNLLKIIAMAKKKFPI
LGICLGLQALAQSYGAKIIRSKEIVHGKATAIALKKHAVFKGLGESMVVGRYHSLMASGLPKNLEVIAEHDNIPMAIVNE
EDKILAYQFHPESIMTLQGRALLEQSVGFLEGLL

Sequences:

>Translated_194_residues
MKIFFIDNFDSFSYNLVYELECLGYEVAVYQNDIDPSYLMDLMNEESKTPLLFISPGPGNPNSSGNLLKIIAMAKKKFPI
LGICLGLQALAQSYGAKIIRSKEIVHGKATAIALKKHAVFKGLGESMVVGRYHSLMASGLPKNLEVIAEHDNIPMAIVNE
EDKILAYQFHPESIMTLQGRALLEQSVGFLEGLL
>Mature_194_residues
MKIFFIDNFDSFSYNLVYELECLGYEVAVYQNDIDPSYLMDLMNEESKTPLLFISPGPGNPNSSGNLLKIIAMAKKKFPI
LGICLGLQALAQSYGAKIIRSKEIVHGKATAIALKKHAVFKGLGESMVVGRYHSLMASGLPKNLEVIAEHDNIPMAIVNE
EDKILAYQFHPESIMTLQGRALLEQSVGFLEGLL

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787517, Length=189, Percent_Identity=40.2116402116402, Blast_Score=163, Evalue=8e-42,
Organism=Escherichia coli, GI1789760, Length=185, Percent_Identity=38.9189189189189, Blast_Score=129, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=198, Percent_Identity=37.8787878787879, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323873, Length=108, Percent_Identity=38.8888888888889, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 21438; Mature: 21438

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIFFIDNFDSFSYNLVYELECLGYEVAVYQNDIDPSYLMDLMNEESKTPLLFISPGPGN
CEEEEEECCCCCEEEEEEEEEECCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCC
PNSSGNLLKIIAMAKKKFPILGICLGLQALAQSYGAKIIRSKEIVHGKATAIALKKHAVF
CCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHCHHEEECCHHCCCCHHEEEHHHHHHH
KGLGESMVVGRYHSLMASGLPKNLEVIAEHDNIPMAIVNEEDKILAYQFHPESIMTLQGR
HCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEECCCCEEEECCH
ALLEQSVGFLEGLL
HHHHHHHHHHHHCC
>Mature Secondary Structure
MKIFFIDNFDSFSYNLVYELECLGYEVAVYQNDIDPSYLMDLMNEESKTPLLFISPGPGN
CEEEEEECCCCCEEEEEEEEEECCEEEEEEECCCCHHHHHHHHCCCCCCCEEEEECCCCC
PNSSGNLLKIIAMAKKKFPILGICLGLQALAQSYGAKIIRSKEIVHGKATAIALKKHAVF
CCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHCHHEEECCHHCCCCHHEEEHHHHHHH
KGLGESMVVGRYHSLMASGLPKNLEVIAEHDNIPMAIVNEEDKILAYQFHPESIMTLQGR
HCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEECCCCEEEECCH
ALLEQSVGFLEGLL
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]