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Identifier: 15645835

GI number: 15645835

Start: 1296384

End: 1297088

Strand: Reverse

Name: Not Available

Synonym: HP1221

Alternate gene names: 15645835

Gene position: 1297088-1296384 (Counterclockwise)

Preceding gene: 15645836

Following gene: 15645834

Centisome position: 77.77

GC content: 37.87

Gene sequence:

>705_bases
TTGGACAACACTCTCAAACATCTTGCCATTATTATGGATGGTAATGGCAGGTGGGCTAAATTAAAGAATAAAGCTAGGGC
TTATGGCCATAAAAAGGGCGTAAAAACCCTTAAAGATATCACGATCTGGTGCGCTAACCATAAGCTAGAATGCTTGACTT
TATACGCTTTTTCTACGGAAAATTGGAAACGCCCTAAGAGTGAAGTGGATTTTTTAATGAAAATGCTTAAAAAATACCTT
AAAGATGAGCGATCCACTTATTTAAATAATAACATACGCTTCAGGGCGATAGGGGATTTAGAGGGCTTTTCTAAAGAATT
ACGAGATACGATTTTGCAGCTTGAAAACGATACCAGGCATTTTAAGGATTTTACGCAAGTTTTAGCCCTTAATTACGGAT
CTAAAAACGAACTTTCAAGGGCGTTTAAAAGCTTGCTAGAAAGCCCGCCTAGCCATATAAACCTTTTAGAAAGTTTAGAA
AATGAAATTTCTAATCGTTTAGACACGCATGATTTGCCGGAAGTGGATTTGTTGTTACGGACAGGGGGGGAAATGCGCTT
GTCTAATTTTTTATTGTGGCAGTCCAGCTATGCGGAATTGTTTTTCACGCCGATTTTATGGCCTGATTTCACCCCTAAAG
ATTTAGAAAACATCATTAGCGATTTTTACAAAAGAGTGCGCAAATTCGGGGAATTAAAATGCTAG

Upstream 100 bases:

>100_bases
GAAAAAACCCGATTTTCTTGGCAGCATATCGCTTATTTAGTGGATGCTTGCACGCTTTAAATGGTGTATAATTAAAGAAT
TTCTTTAAAGGGTAAAGGCA

Downstream 100 bases:

>100_bases
TAGAAATAGAGAATTTGACTAAAACCTATGGGAGTTTAAAAGCGTTAGACAATATCAATTTGAAACTACCCAAACAGCAA
TTTATAGGGCTTTTAGGCCC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYL
KDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLENDTRHFKDFTQVLALNYGSKNELSRAFKSLLESPPSHINLLESLE
NEISNRLDTHDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC

Sequences:

>Translated_234_residues
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYL
KDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLENDTRHFKDFTQVLALNYGSKNELSRAFKSLLESPPSHINLLESLE
NEISNRLDTHDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
>Mature_234_residues
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYL
KDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLENDTRHFKDFTQVLALNYGSKNELSRAFKSLLESPPSHINLLESLE
NEISNRLDTHDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=226, Percent_Identity=36.7256637168142, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI45580738, Length=226, Percent_Identity=36.283185840708, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=43.3628318584071, Blast_Score=196, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71993029, Length=211, Percent_Identity=33.175355450237, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=242, Percent_Identity=31.404958677686, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319474, Length=222, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=33.0143540669856, Blast_Score=114, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27455; Mature: 27455

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTE
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEEECCC
NWKRPKSEVDFLMKMLKKYLKDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLENDTRH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHH
FKDFTQVLALNYGSKNELSRAFKSLLESPPSHINLLESLENEISNRLDTHDLPEVDLLLR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
TGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDNTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTE
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEEEECCC
NWKRPKSEVDFLMKMLKKYLKDERSTYLNNNIRFRAIGDLEGFSKELRDTILQLENDTRH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHH
FKDFTQVLALNYGSKNELSRAFKSLLESPPSHINLLESLENEISNRLDTHDLPEVDLLLR
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
TGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]